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ERRalpha is abundantly expressed in H(+)-pump-rich cells, a group of ionocytes responsible for H(+) secretion in the skin of developing embryos, and its expression is stimulated by acidic environments. Knockdown of ERRalpha impairs both basal and low pH-induced H(+) secretion in the yolk-sac skin, which is accompanied by decreased expression of H(+)-secreting-related transporters.
To gain insights into the possible functions of ERRs during early development, we have cloned their homologs in the zebrafish.
Results propose Estrogen Receptor-Relatedalpha as a new regulator of morphogenetic movement during gastrulation, independently of cell fate determination.
The results identify TGFB1 and ESRRA as likely transcriptional regulators of rumen epithelial development and energy metabolism, respectively, and provide targets for modulation of rumen development and function in the growing calf.
ERalpha, is only expressed in the caruncle of the placenta.
ERalpha mRNA-expressing neurons (ERalpha neurons) were distributed in some structures of the telencephalon, diencephalon, mesencephalon, and hindbrain.
Findings suggest that PGF(2alpha) regulates luteolysis by ESR1 mRNA down-regulation.
Transcriptome and ChIP-seq analyses and found that many genes that were co-regulated by both THRB1 and ESRRA were involved in mitochondrial metabolic pathways.
These findings support the therapeutic application of resveratrol and ERR-alpha in combating obesity-mediated cardiac dysfunction.
results reveal a novel ERRalpha/RANK axis by which ERRalpha in primary breast cancer promotes early dissemination of cancer cells to bone. These findings suggest that ERRalpha may be a useful therapeutic target to prevent bone metastases.
this study identifies ESRRA as a critical activator of autophagy via both transcriptional and posttranslational control to promote antimicrobial host responses.
Systemic ablation of ERRalpha in mice demonstrated clear beneficial effects for loss of ERRalpha function in protection from HFD-provoked body weight gain manifested not only from a reduction in white adipose tissue stores but also from an impediment in intrahepatic lipid accumulation. The prevention of HFD-induced NAFLD in ERRalpha-null mice was underscored by transcriptional repression of de novo lipogenesis.
ERRalpha overexpression attenuated Tau phosphorylation at selective sites in an animal model of Alzheimer's disease.
This work reveals a molecular mechanism by which ERRalpha-induced metabolic reprogramming promotes survival of lapatinib-resistant cancer cells.
the involvement of ERRalpha in the progression of cisplatin-induced AKI is probably through impaired mitochondrial dynamics
Localizing ESRRA binding sites in cortical chromatin, it has been shown that this nuclear receptor binds both differentially expressed energy-related and neurodevelopmental transcription factor genes during social challenge.
The Genomic Context and Corecruitment of SP1 Affect ERRalpha Coactivation by PGC-1alpha in Muscle Cells
findings highlight a MYC/ERRalpha pathway that contributes to physiological and pathological bone loss by integrating the MYC/ERRalpha axis to drive metabolic reprogramming during osteoclast differentiation
Study performed a structural and functional assessment of glutamatergic synapses on medium spiny neurons in the nucleus accumbens of Esrra-null mice, and discovered sex-specific alterations in miniature excitatory postsynaptic currents frequency and amplitude, reduced paired-pulse ratio, and reduction in glutamatergic synaptic vesicles consistent with altered functional connectivity
The nuclear receptor, estrogen-related receptor alpha (ERRalpha), was shown to regulate the expression of genes required for lactate utilization.
In bone, the effects of cholesterol, statin, and bisphosphonate on osteoclastogenesis require ERRalpha; and consequently, cholesterol-induced bone loss or bisphosphonate osteoprotection is lost in ERRalpha knockout mice.
We conclude that E2-induced ERRalpha expression in endothelium plays an important role for the E2-induced vasculoprotective effect
Exercise-induced changes in tumour LDH-B and MCT1 expression are modulated by oestrogen-related receptor alpha in breast cancer-bearing BALB/c mice
These results indicate that Esrra deficiency in the mouse brain impairs behavioral responses in multiple functional domains.
Suppressed feeding behavior in novelty stress-exposed aged male mice may be mediated by 5-HT(2C)R hypersensitivity, leading to hypoghrelinemia. The hypersensitivity may partly be due to estrogen receptor activation in aged male mice.
ERRa is a negative regulator of TLR-induced inflammatory responses through inducing Tnfaip3 transcription and controlling the metabolic reprogramming.
study shows that ERRalpha plays a key role in directing transcriptional programs required for optimal mitochondrial oxidative potential and muscle fitness
Low ERRA expression is associated with development of hepatic cellular carcinoma.
ERG expressed by the TMPRSS2:ERG fusion could also transactivate the ERRalpha (ESRRA) gene.
EZH2 as a relevant coregulator for estrogen-related receptors alpha, beta and gamma in breast carcinoma.
The present data indicated that ERRa acted as an oncogene in colon cancer cells, and the combined targeting of ERRa and MEK might be a promising therapeutic strategy for colon cancer treatment
data showed that activation of NF-kappaB/IL-6 is involved in ERRalpha induced migration and invasion of non-small cell lung cancer cells; it suggested that ERRalpha might be a potential target for non-small cell lung cancer treatment
Results show that ERRA is an interacting partner of PGC1a in a subset of human melanoma cells. Also, ERRA promotes mitochondrial oxidative metabolism in melanoma cells.
LSD1 and ERRalpha coregulate several target genes involved in cell migration, including the MMP1 matrix metallo-protease, also activated through H3K9 demethylation at the transcriptional start site.
TGF-beta treatment can trigger the epithelial-mesenchymal transition of osteosarcoma cells via ERRalpha/Snail pathways.
LC3B and ESRRA might be a useful prognostic factor in patients with muscle-invasive bladder cancer. The co-expression of LC3B and ESRRA might be a prognostic and therapeutic target for patients with bladder cancer.
These findings indicate that ERRalpha may serve as a novel molecular target for the treatment of endometrial cancer
Gls is a novel ERRalpha target gene.
can trigger the proliferation and migration of colorectal cancer cells via up regulation of IL-8
curcumin suppressed the ERRalpha gene expression through upregulation of miR-125a. Data from this study revealed a novel mechanism for curcumin-mediated apoptotic cell death, which involves tumor cell killing via activating miR-125a/ERRalpha pathway.
blocking the ERRalpha-controlled mitochondrial program largely inhibits the PLA2R1-induced tumor-suppressive response. Together, our data document ERRalpha and its mitochondrial program as downstream effectors of the PLA2R1-JAK2 pathway leading to oncosuppression.
results suggest that the decreased expression of miR-135a in metastatic tumors leads to elevated ERRalpha expression, resulting in increased cell invasion capacities.
HO-1-derived CO enhances mitochondrial biogenesis in astrocytes by activating L-type Ca(2+) channel-mediated PGC-1alpha/ERRalpha axis, leading to maintenance of astrocyte function and neuroprotection/recovery against damage of brain function
in ERalpha negative breast cancer, the low level of ERalpha reduced miR-497 expression, which promoted ERRalpha expression that enhanced cell proliferation, migration, and invasion by increasing MIF expression and MMP9 activity.
these data show that ERRalpha expression predicts response to tamoxifen treatment, and ERRalpha could be a biomarker of tamoxifen sensitivity and a prognostic factor in TNBC.
Results show that miR-125a inhibits porcine preadipocytes differentiation through targeting ERRa.
XCT790 significantly inhibited the expression of ERR alpha and lipid accumulation in porcine mature adipocytes.
The protein encoded by this gene is a nuclear receptor that is closely related to the estrogen receptor. This protein acts as a site-specific transcription regulator and has been also shown to interact with estrogen and the transcripton factor TFIIB by direct protein-protein contact. The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium-chain acyl coenzyme A dehydrogenase (MCAD) and thyroid hormone receptor genes. A processed pseudogene of ESRRA is located on chromosome 13q12.1.
, estrogen-related receptor 1
, steroid hormone receptor ERR1
, estrogen-related receptor alpha
, Steroid hormone receptor ERR1 (Estrogen-related receptor, alpha) (ERR-alpha) (Estrogen receptor-like 1)
, estrogen receptor related 1
, estrogen receptor-like 1
, nuclear receptor subfamily 3 group B member 1
, estrogen-related receptor, alpha
, orphan nuclear receptor
, estrogen-related nuclear receptor alpha