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Cow (Bovine) Polyclonal ESRRG Primary Antibody for IHC, WB - ABIN2777400
Hentschke, Borgmeyer: Identification of PNRC2 and TLE1 as activation function-1 cofactors of the orphan nuclear receptor ERRgamma. in Biochemical and biophysical research communications 2003
Show all 3 Pubmed References
Human Polyclonal ESRRG Primary Antibody for ELISA, WB - ABIN314284
Dufour, Wilson, Huss, Kelly, Alaynick, Downes, Evans, Blanchette, Giguère: Genome-wide orchestration of cardiac functions by the orphan nuclear receptors ERRalpha and gamma. in Cell metabolism 2007
This study suggests that the ESRRG rs1890552 A > G polymorphism may modulate interindividual differences in atrial stiffness, with a reduction in fasting glucose in response to dietary advice in subjects with IFG after a 3.5-year follow-up.
EZH2 as a relevant coregulator for estrogen-related receptors alpha, beta and gamma in breast carcinoma.
ESRRG functions as a negative regulator of the Wnt signaling pathway in gastric cancer.
ERRgamma may exert oncogenic activity mainly associated with aggressiveness of EC by activating S100A4 transcription.
Loss of ERRgamma in renal epithelial cells Results in Kidney Disease with Cysts.
our present results show an intriguing association between the ESRRG rs1890552 GG genotype and an increased risk of impaired fasting glucose or type 2 diabetes mellitus as well as increased oxidative stress.
It was also associated with beta-cell function (P=1.99 x 10(-3)) and fasting glucose level (P<0.05) in the meta-analyses of glucose and insulin-related traits consortium (MAGIC) data set.Cnoclusions:In summary, we identified epigenomic characteristics for obesity genes and suggested ESRRG as a novel obesity-susceptibility gene
this study elucidates a molecular mechanism linking CB1R signaling, ERRgamma expression and fibrinogen gene transcription.
Disruption of the orphan receptor ESRRG and disruption of KIAA0825 identified in a subject with hearing loss and mild developmental delay. Given the translocation breakpoints and supporting literature, disruption of ESRRG is the most likely cause for the disorder.
Data suggest that activation of ERRgamma is involved in induction of matrix metalloproteinases 2/9 (MMP2 and MMP9) and increased migration/invasiveness of triple-negative breast cancer cells caused by low concentrations of environmental endocrine disruptors (nanomolar bisphenol A used here).
The present results strongly suggest that human nuclear receptor ERRgamma functions as a genuine homomeric dimer with symmetrical dimeric interface regions.
ERRgamma overexpression directs metabolic maturation in human Induced Pluripotent Stem Cells-derived beta-like cells.
Estrogen-related receptor gamma is upregulated in liver cancer and its inhibition suppresses liver cancer cell proliferation via induction of p21 and p27.
Data show that micrRNA miR-320a directly targets cAMP-regulated phosphoprotein 19 (ARPP-19) and estrogen-related receptor gamma protein (ERRgamma) in breast cancer cell lines.
ERRgamma signaling is associated with poor DMFS in ER+, TAM-treated breast cancer
ESRRG is down-regulated in placenta from intrauterine growth restriction tissue.
Results suggest that hypoxia-inducible factor-1alpha can positively regulate the dopaminergic phenotype through estrogen-related receptor gamma .
The results reveal that the double-layer binding sites, namely, the ordinary ligand binding sites and their back support residues, substantiate the strong binding of BPA to ERRgamma.
A role for ESRRG in maternal blood pressure homeostasis during pregnancy.
Report estrogen-mediated cell kinetics and the role of oestrogen-related receptor gamma on biliary epithelial cells in the pathogenesis of primary biliary cirrhosis.
ERRgamma-driven transcriptional reprogramming largely rescues muscle damage and improves muscle function in PGC1alpha/beta double-knockout mice, inducing mitochondrial biogenesis, antioxidant defense, angiogenesis, and a glycolytic-to-oxidative fiber-type transformation independent of PGC1alpha/beta.
Estrogen-related receptor gamma (ERRgamma) overexpression in chondrocytes directly upregulates matrix metalloproteinase (MMP)-3 and MMP13, which are known to play crucial roles in cartilage destruction in osteoarthritis (OA).
MiR-204-5p inhibits myoblast differentiation by targeting MEF2C and ERRgamma.
Muscle ERRgamma over-expression successfully triggered glycolytic-to-oxidative myofiber switch, increased functional mitochondrial content and boosted vascular supply in the db/db mice.
The research findings suggest that estrogen-related receptor gamma (ERRgamma) regulates testicular steroidogenesis, both directly controlling and indirectly fine-tuning the expression of steroidogenic genes.
These findings strongly support a role for ERRgamma in the metabolic alterations that underlie the development of diabetic cardiomyopathy.
our results reveal that ERRgamma, induced via activation of the hepatic CB1 receptor, is a regulator of hepatic FGF21 gene expression and secretion.
Study conclude that O-GlcNAcylation of ERRgamma serves as a major signal to promote hepatic gluconeogenesis.
Mice deficient in beta cell-specific ERRgamma expression are glucose intolerant and fail to secrete insulin in response to a glucose challenge.
mediates metabolic transition, which is required for induced pluripotency
ERRgamma plays a key role in vascular calcification by upregulating the BMP2 signaling pathway.
Mice lacking neuronal ERRgamma in cerebral cortex and hippocampus exhibit defects in spatial learning and memory.
GSK5182 suppresses hypoxia-induced VEGF expression via ERRgamma; therefore, ERRgamma could be a treatment target for ischemic retinopathies
These results suggest that ERRgamma is a major contributor to insulin action in maintaining hepatic glucose homeostasis.
ERRgamma is a sexdependent and RUNX2-dependent negative regulator of osteoblast differentiation, and that its regulatory activity may also be differentiation stage-dependent.
Mice lacking both ERRalpha and cardiac Errg develop severe bradycardia, lethal cardiomyopathy, and heart failure featuring metabolic, contractile, and conduction dysfunctions.
Orphan nuclear receptor Errgamma induces C-reactive protein gene expression through induction of ER-bound Bzip transmembrane transcription factor CREBH.
Cartilage-specific overexpression of ERRgamma results in chondrodysplasia and reduced chondrocyte proliferation.
These findings demonstrate a novel ERRgamma/GATA4 signal cascade in the development of cardiac hypertrophy.
This gene encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors\; they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified, which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region.
, estrogen receptor-related protein 3
, nuclear receptor subfamily 3 group B member 3
, estrogen-related receptor gamma
, Usher syndrome 2A (autosomal recessive, mild)
, estrogen-related receptor beta/gamma
, estrogen-related receptor 3
, estrogen-related receptor gamma-like