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Cow (Bovine) Polyclonal ESRRG Primary Antibody for IHC, WB - ABIN2777400
Hentschke, Borgmeyer: Identification of PNRC2 and TLE1 as activation function-1 cofactors of the orphan nuclear receptor ERRgamma. in Biochemical and biophysical research communications 2003
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Human Polyclonal ESRRG Primary Antibody for ELISA, WB - ABIN314284
Dufour, Wilson, Huss, Kelly, Alaynick, Downes, Evans, Blanchette, Giguère: Genome-wide orchestration of cardiac functions by the orphan nuclear receptors ERRalpha and gamma. in Cell metabolism 2007
This gene encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors\; they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified, which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region.
, estrogen receptor-related protein 3
, nuclear receptor subfamily 3 group B member 3
, estrogen-related receptor gamma
, Usher syndrome 2A (autosomal recessive, mild)
, estrogen-related receptor beta/gamma
, estrogen-related receptor 3
, estrogen-related receptor gamma-like