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High MED1 expression is associated with metastasis in breast Cancer.
maintenance of the cancer cell state is dependent on recruitment of Mediator and Cohesin through FOXA and master transcription factors
co-expression of PPARgamma (show PPARG Proteins) and TRAP220 represents a biomarker for good prognosis in colorectal cancer patients
Data suggest that mediator complex subunit 1 (Med1/TRAP220) is a target for checkpoint kinase 2 (Chk2 (show CHEK2 Proteins))-mediated phosphorylation and may play a role in cellular DNA damage responses by mediating proper induction of gene transcription upon DNA damage.
In a cohort of youth at risk for bipolar disorder, pathway analysis showed an enrichment of the glucocorticoid receptor (GR (show NR3C1 Proteins)) pathway with the genes MED1, HSPA1L (show HSPA1L Proteins), GTF2A1 (show GTF2A1 Proteins) and TAF15 (show TAF15 Proteins), which might underlie the previously reported role of stress response in the risk for bipolar disorder in vulnerable populations.
modulation of ESR1 (show ESR1 Proteins)-MED1 interactions by cAMP signaling plays a critical role in human decidualization.
Our data indicate that MED1 serves as a key mediator in ARv567es induced gene expression
Results show that miR-1 (show FSD1 Proteins) is downregulated in osteosarcoma cells but both of its targets Med1 and Med31 (show MED31 Proteins) were overexpressed suggesting that MiR-1 (show FSD1 Proteins) plays an important role on the proliferation of osteosarcoma cells through regulation of Med1 and Med31 (show MED31 Proteins).
MED1 is required for optimal PRDM16 (show PRDM16 Proteins)-induced Ucp1 (show UCP1 Proteins) expression
no association between SCZ and the SNPs of VDR (show CYP27B1 Proteins), suggesting that VDR (show CYP27B1 Proteins) is not a major gene for SCZ in Chinese Han population. However, our data indicate a potential involvement of VDR (show CYP27B1 Proteins) SNPs in the susceptibility of risperidone-treated patients to MetS (show ETV3 Proteins)
High MED1 (show MBD4 Proteins) expression is associated with metastasis in breast Cancer.
Data, including data from studies using cells from transgenic/knockout mice, suggest that Med1 (show MBD4 Proteins) plays role in enamel formation; Med1 (show MBD4 Proteins) induces Alpl (show ALPL Proteins) via stimulation of Notch1 (show NOTCH1 Proteins) signaling by forming Notch1 (show NOTCH1 Proteins)-RBP-Jk (show RBPJ Proteins) complex on Alpl (show ALPL Proteins) promoter. (Med1 (show MBD4 Proteins) = mediator complex subunit 1; Alpl (show ALPL Proteins) = alkaline phosphatase, liver-bone-kidney; Notch1 (show NOTCH1 Proteins) = Notch gene homolog 1 (show NOTCH1 Proteins); RBP-Jk (show RBPJ Proteins) = kappa J region recombining binding protein suppressor of hairless (show RBPJ Proteins))
MED1 (show MBD4 Proteins) in macrophages has an antiatherosclerotic role via PPARgamma (show PPARG Proteins)-regulated transactivation.
Cardiomyocyte-specific ablation of Med1 (show MBD4 Proteins) causes lethal dilated cardiomyopathy in mice.
Med1 (show MBD4 Proteins) deletion disrupted cardiac mitochondrial and metabolic gene expression patterns
Med1 and Med12, two subunits of the mediator complex implicated in transcription initiation and long-range enhancer/promoter loop formation, are dynamically recruited to the IgH locus enhancers.
We conclude that MED1 (show MBD4 Proteins) regulates the temporal progression of primary spermatocytes through meiosis, with its absence resulting in abbreviated pre-leptotene, leptotene, and zygotene stages, and a prolonged pachytene stage.
These results demonstrate that Med1 (show MBD4 Proteins) is a master regulator in adult stem cells to govern epithelial cell fate
The novel function of MED1 (show MBD4 Proteins) in keratinocytes.
PRDM16 (show PRDM16 Proteins) deficiency in BAT (show BAAT Proteins) reduces MED1 (show MBD4 Proteins) binding at PRDM16 (show PRDM16 Proteins) target sites and causes a fundamental change in chromatin architecture at key brown fat-selective genes
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize.
, PPAR binding protein
, PPAR-binding protein
, PPARG binding protein
, TR-interacting protein 2
, activator-recruited cofactor 205 kDa component
, mediator of RNA polymerase II transcription subunit 1
, p53 regulatory protein RB18A
, peroxisome proliferator-activated receptor-binding protein
, thyroid hormone receptor-associated protein complex 220 kDa component
, thyroid hormone receptor-associated protein complex component TRAP220
, thyroid receptor interacting protein 2
, thyroid receptor-interacting protein 2
, vitamin D receptor-interacting protein 230 kD
, vitamin D receptor-interacting protein complex component DRIP205
, mediator complex subunit 1
, peroxisome proliferator-activated receptor binding protein
, membrane component, chromosome 17, surface marker 2
, Ppar binding protein
, peroxisome proliferator activated receptor binding protein