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Human Polyclonal NR1I2 Primary Antibody for IF (p), IHC (p) - ABIN679598
Sehirli, Cetinel, Ozkan, Selman, Tetik, Yuksel, Dulger: St. John's wort may ameliorate 2,4,6-trinitrobenzenesulfonic acid colitis off rats through the induction of pregnane X receptors and/or P-glycoproteins. in Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2015
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Human Polyclonal NR1I2 Primary Antibody for IHC, WB - ABIN2774988
Hesselink, van Schaik, Nauta, van Gelder: A drug transporter for all ages? ABCB1 and the developmental pharmacogenetics of cyclosporine. in Pharmacogenomics 2008
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Human Polyclonal NR1I2 Primary Antibody for IHC, ELISA - ABIN1584988
Yau, Liu, Fairlie: Toward drugs for protease-activated receptor 2 (PAR2). in Journal of medicinal chemistry 2013
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Human Polyclonal NR1I2 Primary Antibody for ELISA, WB - ABIN449909
Thakur, Arthanari, Yang, Pan, Fan, Breger, Frueh, Gulshan, Li, Mylonakis, Struhl, Moye-Rowley, Cormack, Wagner, Näär: A nuclear receptor-like pathway regulating multidrug resistance in fungi. in Nature 2008
High endogenous pregnane X receptor (PXR) level is associated with poor sorafenib therapy outcome.
A total of six studies with 4248 cases and 3853 controls were included in this meta-analysis. Three PXR gene polymorphisms were evaluated: rs1523127, rs2276707, and rs6785049. Our analyses of rs1523127, rs2276707, and rs6785049 suggested that PXR gene polymorphism had no obvious influence on the risk of inflammatory bowel disease in Caucasians.
genotypes and haplotypes of PXR rs3814057, rs3814058 and rs6785049 have impact on the major adverse cardiovascular events in clopidogrel treated patients after percutaneous coronary intervention
replication confirmed at genome-wide significance the association of loci at FOXE1 with hypothyroidism, and PDE8B, CAPZB and PDE10A with serum TSH. A total of 12 SNPs seemed to explain nearly 7% of the serum TSH variation
NR1I2 has a role in promoting stem cell-mediated colon cancer relapse
Dual ligands of CAR/PXR show distinct gene regulation patterns by regulating cross-talk between CAR and PXR.
High PXR expression is associated with multidrug resistance in breast cancer.
PXR, CYP3A4 (show CYP3A4 Antibodies), and VIL1 (show VIL1 Antibodies) expression was decreased only in the actively inflamed small intestinal tissue in children with Crohn's disease.
NR1I2 g.7635A>G had a significant interaction with time, but the dose-adjusted tacrolimus concentration did not significantly differ over 5 years post-transplantation, except for the GG genotype of NR1I2 g.7635A>G.
Together, our results suggest that protection of the endothelial barrier by APC (show APC Antibodies)/TR47-mediated signaling pathways might be a valuable therapeutic approach to prevent metastasis
The regulatory effect of IFN-gamma (show IFNG Antibodies) on CYP3A29 expression is mediated via PXR.
Pregnane X receptor is required for interferon-alpha-mediated CYP3A29 expression, and its expression before CYP3A29.
In conclusion, PXR and FXR (show NR1H4 Antibodies) both responded to ligands that activated their human orthologs, and some of the alternatively spliced variants significantly altered PXR and FXR (show NR1H4 Antibodies) transactivation at in vivo expression levels.
the PXR gene revealed multiple splice variants in the ligand-binding domain
Data suggest that regulation of SXR expression is involved in nephrosis induced by environmental poisons; here, nephrosis caused by atrazine herbicide poisoning can be mitigated by supplementation with antioxidant lycopene; in the kidney, mechanisms involved include modulation of SXR expression and of SXR transport to the nucleus.
FXR (show NR1H4 Antibodies) signaling is a bile acid nuclear receptor that regulates lipids and glucose homeostasis and lack of it causes hepatomegaly and liver dysfunction.
Both the acetylation and SUMOylation status of the PXR protein is affected by its ability to associate with the lysine de-acetylating enzyme HDAC3 in a complex with SMRT.
The present study has revealed known and novel, as well as common and unique targets of PXR and CAR in mouse liver following pharmacological activation using their prototypical ligands.
FGF21 (show FGF21 Antibodies)-PXR signaling pathway may be involved in decreased hepatic CYP3A4 (show CYP3A4 Antibodies) metabolic activity in Nonalcoholic fatty liver disease.
Pregnenolone 16alpha-carbonitrile has immunosuppressive activity independent of PXR activation to protect mice from immune-mediated liver injury induced by Con (show KITLG Antibodies) A.
carcinogens might trigger PXR in epidermal cells, particularly in Langerhans cells, leading to DNA damage
PXR activation stimulates EGF (show EGF Antibodies)-mediated hepatocyte proliferation in mice, at least in part, through inhibiting FOXO3 (show FOXO3 Antibodies) from accelerating cell-cycle progression.
The role of intestinal PXR in linking xenobiotic exposure and hyperlipidemia.
modulation of vemurafenib bioavailability through pregnane X receptor-mediated regulation of drug transporters has the potential to markedly influence systemic exposure and thereby therapeutic outcomes.
Selected zebrafish CYP1 (show PPIA Antibodies), CYP2 and CYP3 genes appear to be under the regulation of both pregnane X receptor and aryl hydrocarbon receptor (show AHR Antibodies) 2.
CYP3A65 and PXR may be involved in the metabolization and detoxification of microcystins in zebrafish, which may be regulated by dre (show SUFUH Antibodies)-miR (show MYLIP Antibodies)-27b.
similar pattern of mRNA expression of PXR, cytochrome P4503A and multiple drug resistance 1 genes found in fish treated with different PXR inducers suggests that the intrinsic association between these three genes is conserved in zebrafish
This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized.
nuclear receptor subfamily 1 group I member 2
, orphan nuclear receptor PAR1
, orphan nuclear receptor PXR
, pregnane X nuclear receptor variant 2
, pregnane X receptor
, steroid and xenobiotic receptor
, Pregnane X receptor
, nuclear receptor subfamily 1, group 1, member 2
, pregnane X receptor (nuclear receptor sub family 1, group I, member 2)
, nuclear receptor subfamily 1 group I member 2 S homeolog
, nuclear receptor subfamily 1, group I, member 2
, orphan nuclear receptor BXR-beta