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findings suggest that PPARdelta conditions CLL cells to survive in harsh microenvironmental conditions by reducing oxidative stress and increasing metabolic efficiency.
Here, theauthors describe a novel PPARbeta/delta-dependent molecular cascade involving TGFbeta1 (show TGFB1 Proteins) and miR (show MLXIP Proteins)-21-3p, which is activated in the epidermis in response to UV exposure.
findings identified previously unrecognized role of IP-PPARdelta signal transduction pathway in the production of sAPPalpha in cerebral microvasculature.
PPAR-delta activation prevents in-stent restenosis and stent thrombosis.
findings identify LPCAT3 (show LPCAT3 Proteins) as a direct PPARdelta target gene and suggest a novel function of PPARdelta in regulation of phospholipid metabolism through LPCAT3 (show LPCAT3 Proteins).
The minor allele of rs2016520 and rs9794 in PPAR-delta and interaction between rs2016520 and non-smoking were associated with decreased risk of CVD.
a novel SNP x SNP interaction between rs2267668 in PPARdelta and rs7191411 in EMP2 that has significant impact on circulating HDL (show HSD11B1 Proteins)-C levels in the Singaporean Chinese population.
Results indicate that PPARdelta-mediated downregulation of Nox4 (show NOX4 Proteins) modulates cellular redox status, which in turn plays a critical role in extracellular matrix homeostasis through ROS (show ROS1 Proteins)-dependent regulation of MMP-2 (show MMP2 Proteins) activity.
The PPAR delta role in neuroblastoma (show ARHGEF16 Proteins) cell tumorigenesis and differentiation
PPARdelta activation may be a potential risk of atherosclerosis through enhancing activity of SMS2 (show SGMS2 Proteins)
Data suggest that interaction of Ppard with Tcptp45 blunts insulin (show INS Proteins) resistance and leads to retention of Tcptp45 in nucleus of hepatocytes, myotubes, and adipocytes; alteration of such interactions may be involved in insulin (show INS Proteins) resistance observed in obesity. (Ppard = peroxisome proliferator activator receptor delta; Tcptp45 = protein tyrosine phosphatase non-receptor type 2 (show PTPN2 Proteins) [Ptpn2 (show PTPN2 Proteins)], 45kDa (show NFE2 Proteins) alternative splicing variant)
CRY1 (show CRY1 Proteins)/2 seem to repress a distinct subset of PPAR delta target genes in muscle compared to the co-repressor NCOR1 (show NCOR1 Proteins). In vivo, genetic disruption of Cry1 (show CRY1 Proteins) and Cry2 (show CRY2 Proteins) enhances sprint exercise performance in mice.
CD36 (show CD36 Proteins) is essential for endurance improvement, changes in whole-body metabolism, and efficient peroxisome-proliferator activated receptors (PPAR (show PPARA Proteins))-related transcriptional responses in the muscle with exercise training.
Exhaustion of systemic glucose limits endurance exercise. PPARdelta regulates substrate utilization without mitochondrial biogenesis. PPARdelta represses glycolytic genes in muscle to slow glucose consumption. Glucose sparing by PPARdelta dramatically extends running time.
The HFHC diet polarized the liver toward a proinflammatory M1 state, which was reversed by GW1516 intervention. Thus, PPARdelta agonist treatment inhibits the progression of preestablished hepatic steatosis.
data suggested that PPARbeta-regulated PDK1 (show PDPK1 Proteins)/Akt (show AKT1 Proteins) and E2f (show E2F1 Proteins) signaling that controls metabolism and proliferation is involved in the normal progression of liver regeneration
Since the R6/2 mice represent a 'truncated' huntingtin (Htt (show HTT Proteins)) mouse model of Huntington's disease (HD), we tested the efficacy of bezafibrate in a 'full-length' Htt (show HTT Proteins) mouse model, the BACHD mice. Bezafibrate treatment restored the impaired PPARg (show PPARG Proteins), PPARd, PGC (show PGC Proteins)-1a signaling pathway, enhanced mitochondrial biogenesis and improved antioxidant defense in the striatum of BACHD mice
we demonstrated that by modulating mitochondrial energy metabolism through Mfn2 (show MFN2 Proteins) and mitochondrial Ca2 (show CA2 Proteins)+, PPAR-b took an important role in neuronal differentiation induced by flavonoid compound 4a
The results demonstrate that PPARdelta-mediated inhibition of ER stress contributes to the vascular benefits of exercise.
Gene expression of the carnitine transporter OCTN2 (show SLC22A5 Proteins) and carnitine transport are regulated by PPARbeta/delta in bovine cells.
provide evidence that PPARD G32E is the variation underlying the ear size QTL
study provides evidence for an association between PPARD and backfat thickness.
PPAR profiles in bladder smooth muscle (BSM) may contribute to the susceptibility of BSM to lipotoxicity in the metabolic syndrome.
Overexpression of PPARdelta inhibits myotube formation and also enhances adipocyte differentiation in cultured mouse myoblasts.
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. Alternate splicing results in multiple transcript variants.
, nuclear hormone receptor 1
, nuclear receptor subfamily 1 group C member 2
, peroxisome proliferator-activated nuclear receptor beta/delta variant 2
, peroxisome proliferator-activated receptor beta
, Peroxisome proliferator-activated receptor beta
, peroxisome proliferator-activated receptor delta
, peroxisome proliferative activated receptor, delta
, peroxisome proliferator-activated receptor delta-like
, peroxisome proliferator activated receptor delta
, peroxisome proliferator activator receptor beta
, peroxisome proliferator activator receptor, delta
, peroxisome proliferator activator receptor delta