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Human Monoclonal Retinoic Acid Receptor alpha Primary Antibody for EMSA, ICC - ABIN2668711
Reichrath, Mittmann, Kamradt, Müller: Expression of retinoid-X receptors (-alpha,-beta,-gamma) and retinoic acid receptors (-alpha,-beta,-gamma) in normal human skin: an immunohistological evaluation. in The Histochemical journal 1997
Show all 2 Pubmed References
Human Monoclonal Retinoic Acid Receptor alpha Primary Antibody for IHC (fro), WB - ABIN152363
Choi, Park, Sockanathan: Activated retinoid receptors are required for the migration and fate maintenance of subsets of cortical neurons. in Development (Cambridge, England) 2014
Human Polyclonal Retinoic Acid Receptor alpha Primary Antibody for IHC (p), IHC - ABIN268790
Farias, Ong, Ghyselinck, Nakajo, Kuppumbatti, Mira y Lopez: Cellular retinol-binding protein I, a regulator of breast epithelial retinoic acid receptor activity, cell differentiation, and tumorigenicity. in Journal of the National Cancer Institute 2005
Human Monoclonal Retinoic Acid Receptor alpha Primary Antibody for IHC (p), ELISA - ABIN519635
Voss, Collin, Dixon, Thomas: Moz and retinoic acid coordinately regulate H3K9 acetylation, Hox gene expression, and segment identity. in Developmental cell 2009
These results therefore indicate that EGCG targets PML/RARalpha oncoprotein for degradation and potentiates differentiation of promyelocytic leukemia cells in combination with ATRA via PTEN.
Silencing of PML-RAR (show PRAM1 Antibodies) and RARalpha2 results in similar increases in the constitutive expression of several granulocytic differentiation markers.
RARA drives cyclin-dependent kinase (show CDK1 Antibodies) expression, G1-S transition, and cell growth in T-cell lymphoma.
Demonstrate that RARalpha was frequently elevated in gastric carcinoma and exerted oncogenic properties via positive feedback loop of IL-1beta (show IL1B Antibodies)/Akt (show AKT1 Antibodies)/RARalpha/Akt (show AKT1 Antibodies) signaling.
Our findings unveil a novel essential oncogenic activity of PML (show PML Antibodies)/RARA in Acute promyelocitic leukemia
Findings reveal a previously unrecognized role of c-Myc (show MYC Antibodies) as a potential ceRNA for PML (show PML Antibodies)/RARalpha in acute promyelocytic leukemia (show PML Antibodies).
RARalpha regulates Arp2/3-mediated actin cytoskeletal dynamics through a non-genomic signaling pathway
It has been shown that the AP-1 (show FOSB Antibodies) family member JunB (show JUNB Antibodies) and retinoic acid receptor alpha (RARa) mediate catalase (show CAT Antibodies) transcriptional activation and repression, respectively, by controlling chromatin remodeling through a histone deacetylases-dependent mechanism.
Work identifies the TP53 (show TP53 Antibodies) tumor suppressor as a novel target through which NPM1 (show NPM1 Antibodies)-RARA impacts leukemogenesis.
Dual small interfering RNA (siRNA) silencing of RARalpha and RARgamma reversed RA blockade of P4-induced CK5 (show KRT5 Antibodies). Using promoter deletion analysis, we identified a region 1.1 kb upstream of the CK5 (show KRT5 Antibodies) transcriptional start site that is necessary for P4 activation and contains a putative progesterone response element (PRE
RARalpha competes with other PFN2a-binding proteins bearing PRMs and involved in actin filaments elongation. Consequently, the actin filament network is altered and MEFs adhesion is decreased. This novel role opens novel avenues for the understanding of pathologies characterized by increased levels of cytoplasmic RARalpha.
These data suggest that impairment of cardiac RARalpha signaling may be a novel mechanism that is directly linked to pathological stimuli-induced diastolic dysfunction.
Retinoic acid receptor alpha agonist all trans retinoic acid can protect the liver from ischemia reperfusion injury by promoting autophagy, which is dependent on Foxo3 (show FOXO3 Antibodies)/p-Akt (show AKT1 Antibodies)/Foxo1 (show FOXO1 Antibodies) signaling.
both the PML (show PML Antibodies)-RARA-driven competitive transplantation advantage and development of acute promyelocytic leukemia (show PML Antibodies) (APL (show FASL Antibodies)) required DNMT3A (show DNMT3A Antibodies)
the reprogramming of epiblast stem cells into embryonic stem cell-like cells also requires low levels of retinoic acid (RA), which can modulate Wnt (show WNT2 Antibodies) signalling through physical interactions of RARs (show RARS Antibodies) with beta-catenin (show CTNNB1 Antibodies).
our findings challenge the predominant model in the field and we propose that PML (show PML Antibodies)/RARA initiates leukemia by subtly shifting cell fate decisions within the promyelocyte compartment.
DNA-binding-defective PML (show PML Antibodies)/RARA mutants could not repress the transcription of retinoic acid regulated genes.
although X-RARA fusion proteins have been suggested to act by blocking retinoid-dependent transcriptional programs , we observed a surprising paucity of natural retinoids capable of transactivating Gal4 (show LGALS4 Antibodies)-RARA in primary mouse bone marrow cells
The results indicate a physiological role for RARgamma as a negative regulator of osteoclastogenesis in vivo and in vitro, and reveal distinct influences of RARalpha and RARgamma in bone structure regulation.
Data suggest that retinoic acid and GM-CSF (show CSF2 Antibodies)-induced retinal dehydrogenase 2 (RALDH2 (show ALDH1A2 Antibodies)) expression in dendritic cells requires cooperative binding of transcription factor Sp1 (show SP1 Antibodies) via the RA receptor/retinoid X receptor (show RXRB Antibodies) complex to the Aldh1a2 (show ALDH1A1 Antibodies) promoter.
Increased expression of mammary TRbeta1 (show THRB Antibodies) and DIO2 (show DIO2 Antibodies), and decreased RXRalpha (show RXRA Antibodies), provide a mechanism to increase thyroid hormone (show PTH Antibodies) activity within the mammary gland during lactation.
results show role for retinoic acid receptor (show RARB Antibodies) as a regulator of spatial patterning of the pre-placodal ectoderm (PPE)through Tbx1 and RIPPLY3; demonstrate that Ripply3, acting downstream of RAR (show RAB40B Antibodies) signaling, is key player in establishing boundaries in the PPE
This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.
retinoic acid receptor alpha
, retinoic acid receptor, alpha
, retinoic acid receptor alpha-like
, nuclear receptor subfamily 1 group B member 1
, nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form
, retinoic acid nuclear receptor alpha variant 1
, retinoic acid nuclear receptor alpha variant 2
, retinoic acid receptor, alpha polypeptide
, RAR alpha 1
, rar alpha
, xRAR alpha
, retinoic acid receptor alpha 1 isoform