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CYP11A1 (show CYP11A1 Proteins)- derived hydroxyvitamin D derivatives as "inverse" agonists on ROR-alpha and ROR-gamma.
The expression RORalpha is significantly elevated under hypoxic conditions in keratinocytes in an HIF-1alpha (show HIF1A Proteins) dependent manner.
Retinoid-related orphan receptor alpha-regulated development of the mouse cerebellum has a distinct critical period for (1) lengthening Purkinje cell (PC) primary dendrite stems and the eventual increase in the thickness of the molecular layer and (2) the establishment of mGluR (show GRM8 Proteins) signaling and associated removal of surplus climbing fibers from PCs.
findings strongly suggest that CLDND1 is a direct RORalpha target
TRIB3 (show TRIB3 Proteins) promotes acute promyelocytic leukemia (show PML Proteins) progression through stabilization of the oncoprotein PML (show PML Proteins)-RARalpha (show RARA Proteins) and inhibition of p53 (show TP53 Proteins)-mediated senescence.
Retinoid-related orphan receptor alpha (RORalpha) reduction occurs in gastric cancer leading to the survival of tumor cells, which is attenuated by AMP-activated protein kinase (AMPK (show PRKAA2 Proteins)), therefore, both RORalpha and AMPK (show PRKAA1 Proteins) are potential targets for the intervention and therapy in gastric carcinoma.
the RAR-related orphan receptor-a gene (RORA) and the Peroxisome Proliferator-Activated Receptor Gamma (show PPARG Proteins), Coactivator 1 Alpha gene (PPARGC1A or PGC-1alpha) were significantly associated with the Li response. Our results suggest genetic associations between Li response and these two close biological partners: PPARGC1A and RORA involved in circadian rhythms and bioenergetics processes in Li response
The present study is to determine if any relation exists between RORA rs11639084 and rs4774388 gene polymorphisms on the individual susceptibility of multiple sclerosis.
Association between RORA gene polymorphisms and the DSM-5 posttraumatic stress disorder symptoms in male earthquake survivors in China.
The RORA intronic SNP rs11632098 was associated with greater odds of reporting depressive symptoms in older adults.
study reports cloning and expression pattern of zebrafish ROR alpha orthologues rora1 and rora2; both rora1 and rora2 are spatially expressed in the retina and tectum; expression of rora2 was further observed in the cerebellum
RORalpha/gamma are important therapeutic targets for cutaneous inflammation; RORa and RORg (show RORC Proteins) have roles in inflammation in mouse models of atopic dermatitis and acute irritant dermititis
Data demonstrated that the circadian rhythm of testosterone synthesis in TM3 (show TPM1 Proteins) cells was disturbed following Fen treatment as evidenced by changes in the circadian rhythmicity of core clock genes (Bmal1 (show ARNTL Proteins), Rev-erbalpha (show NR1D1 Proteins), Roralpha).
RORalpha inhibits PPARgamma (show PPARG Proteins)-mediated transcriptional activity by interacting with HDAC3 (show HDAC3 Proteins) and competing for the promoters of lipogenic genes.
that retinoic acid receptor-related orphan receptor alpha is a novel transcriptional regulator of SEMA3E (show SEMA3E Proteins)-mediated neurovascular coupling in pathological retinal angiogenesis
The deficiency of LXRalpha (show NR1H3 Proteins) decreased glucose uptake after MI, resulting in a metabolic shift that suppressed glucose metabolism, which was in association with adverse cardiac remodeling.
Data suggest that inflammatory response in macrophages, white adipocytes, and white adipose tissue in obese mice, includes up-regulation of expression of Rora; in adipose tissue, overexpression of Rora or treatment with Rora agonist enhances expression of cytokines, promotes macrophage infiltration, up-regulates expression of genes involved in ER stress response, and enhances signaling seen in unfolded protein response.
these findings reveal that RORalpha regulates macrophage M2 polarization via activation of AMPKalpha (show GRK4 Proteins)
RORalpha regulates pathologic retinal angiogenesis by modulating SOCS3 (show SOCS3 Proteins)-dependent inflammation
This study showed that spontaneous Rora mutations causing cerebellar pathology are impaired in motor functions during the neonatal period.
The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The specific functions of this protein are not known, but it has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Four transcript variants encoding different isoforms have been described for this gene.
nuclear receptor ROR-alpha
, RAR-related orphan receptor A
, RAR-related orphan receptor alpha
, nuclear receptor RZR-alpha
, nuclear receptor subfamily 1 group F member 1
, retinoic acid receptor-related orphan receptor alpha
, retinoid-related orphan receptor alpha
, thyroid hormone nuclear receptor alpha variant 4
, transcription factor RZR-alpha
, retinoid-related orphan receptor alpha 2
, retinoid-related orphan receptor-alpha