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anti-Human RORC Antibodies:
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Human Polyclonal RORC Primary Antibody for ELISA, IHC (p) - ABIN271147
Tosolini, Kirilovsky, Mlecnik, Fredriksen, Mauger, Bindea, Berger, Bruneval, Fridman, Pagès, Galon: Clinical impact of different classes of infiltrating T cytotoxic and helper cells (Th1, th2, treg, th17) in patients with colorectal cancer. in Cancer research 2011
Show all 2 Pubmed References
Human RORC Primary Antibody for - ABIN647764
van Baarsen, Lebre, van der Coelen, Aarrass, Tang, Ramwadhdoebe, Gerlag, Tak et al.: Heterogeneous expression pattern of interleukin 17A (IL-17A), IL-17F and their receptors in synovium of rheumatoid arthritis, psoriatic arthritis and osteoarthritis: possible explanation for ... in Arthritis research & therapy 2015
Cow (Bovine) Polyclonal RORC Primary Antibody for IHC, WB - ABIN2782284
Huang, Xie, Wang, Sun: Retinoid-related orphan receptor gamma t is a potential therapeutic target for controlling inflammatory autoimmunity. in Expert opinion on therapeutic targets 2007
Show all 2 Pubmed References
Cow (Bovine) Polyclonal RORC Primary Antibody for WB - ABIN2777822
Huang, Huang, Lee, Ng, Chang: Postirradiation sinus mucosa disease in nasopharyngeal carcinoma patients. in The Laryngoscope 2007
Show all 2 Pubmed References
Human Monoclonal RORC Primary Antibody for FACS - ABIN4895229
Verma, Dempsey, Long, Davies, Barry, Fallon, Volkov, Kelleher: Leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction induces a novel genetic signature resulting in T-cells refractory to transforming growth factor-β signaling. in The Journal of biological chemistry 2012
Human Monoclonal RORC Primary Antibody for FACS - ABIN4895233
Zielinski, Mele, Aschenbrenner, Jarrossay, Ronchi, Gattorno, Monticelli, Lanzavecchia, Sallusto: Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β. in Nature 2012
Human Monoclonal RORC Primary Antibody for FACS - ABIN4895237
Wongkajornsilp, Wamanuttajinda, Kasetsinsombat, Duangsa-ard, Sa-ngiamsuntorn, Hongeng, Maneechotesuwan: Sunitinib indirectly enhanced anti-tumor cytotoxicity of cytokine-induced killer cells and CD3⁺CD56⁺ subset through the co-culturing dendritic cells. in PLoS ONE 2013
TNF-alpha (show TNF Antibodies) inhibitors decrease histone (H)3 and H4 acetylation in the RORgammat gene promotor region by decreasing the recruitment of the acetyltransferases p300 (show EP300 Antibodies), CBP (show CREBBP Antibodies) and PCAF (show KAT2B Antibodies) in Th17 cells, from rheumatoid arthritis patients.
Here we attempt a comprehensive review of the post-translational regulation of RORgammat, an area that holds the potential to transform the way we target the RORgammat/IL-17 (show IL17A Antibodies) pathway
CYP11A1 (show CYP11A1 Antibodies)- derived hydroxyvitamin D derivatives as "inverse" agonists on ROR-alpha and ROR-gamma.
RORgamma mediates epithelial-mesenchymal transition of hepatocytes during hepatic fibrosis facilitated by TGFbeta1 (show TGFB1 Antibodies).
The interaction between c-Maf (show MAF Antibodies) and RORgammat, and Blimp-1 (show PRDM1 Antibodies).
this review on RORC as a transcription factor required for the generation of type 3 lymphoid cells, which induce the development of lymphoid tissues, provide resistance of epithelial stem cells to injury, maintain homeostasis with the symbiotic microbiota, orchestrate defense against extracellular microbes, and regulate allergic responses
IKKalpha (show CHUK Antibodies)-dependent phosphorylation of S376 stimulated whereas IKKalpha (show CHUK Antibodies)-independent phosphorylation of S484 inhibited RORgammat function in Th17 differentiation.
There are 2 putative binding motifs for specificity protein transcription factors from the specificity protein/Kruppel-like factor family in the promoter of human RORgammaT. SP2 recognized binding motifs in the human RORgammaT promoter, which was critical for maintaining expression.
Results from the study establish RORgamma as a key player in castration-resistant prostate cancer (CRPCa) by acting upstream of AR and as a new therapeutic target for advanced PCa (show FLVCR1 Antibodies).
Data suggest that apo (show C9orf3 Antibodies) RORC adopts active conformation capable of recruiting coactivator peptides that stabilize helix 12 of the active state in the absence of a ligand; ligand-bound RORC binds inverse agonists that disrupt critical interactions that stabilize helix 12; helix 12 destabilization in the active state shifts the conformational equilibrium of RORC toward an inactive state.
The total frequencies for the combined genotypes for the bGH and RORC genes, which provide for superior meat quality and carcass weight, in the populations of Kazakh white-headed cattle
The role of the orphan receptor (show NR1D2 Antibodies) C allele variation on intramuscular fat in beef cattle is reported.
the potential effects of the A2A adenosine receptor (A2AR (show ADORA2A Antibodies)) antagonist SCH (show NF2 Antibodies) 5826 (SCH (show NF2 Antibodies)) and agonist CGS 21680 (CGS) on behavior (self-grooming), hot plate test results, and expression levels of IL-17A (show IL17A Antibodies)(+), RORgammat(+), Foxp3 (show FOXP3 Antibodies)(+), and IL-10 (show IL10 Antibodies)(+) in CD4 (show CD4 Antibodies)(+) T spleen cells in BTBR and C57BL/6 (B6) mice, were investigated.
pharmacological inhibition of RORgamma skews TCRalpha gene rearrangement, limits T cell repertoire diversity, and inhibits development of autoimmune encephalomyelitis.targeting RORgammaT not only inhibits Th17 cell development and function but also fundamentally alters thymic-emigrant recognition of self and foreign antigens.
ubiquitination of K446 limits RORgammat-mediated Th17 differentiation by inhibiting the recruitment of coactivator SRC1 (show NCOA1 Antibodies)
RORgamma/IL-17A (show IL17A Antibodies) axis influences VEGF (show VEGFA Antibodies) production and neovascular retinopathy by mechanisms involving neuroglia. Inhibition of RORgamma and IL-17A (show IL17A Antibodies) may have potential for the improved treatment of neovascular retinopathies.
secretion of IL-17 (show IL17A Antibodies) by biTregs was abrogated completely in FoxP3 (show FOXP3 Antibodies)(Cre) x RORC(fl/fl (show FLT3LG Antibodies)) mice. Furthermore, Tregs showed a more activated phenotype after cell-specific inactivation of RORgammat signalling. Finally, and remarkably, biTregs were found to potently suppress anti-inflammatory Th2 immunity in a RORgammat-dependent manner.
this study reveales a new mechanism through which procyanidin B2 gallates inhibit IFN-gamma and IL-17 production in T cells by down-regulation of T-bet and RORgammat expression
The data suggest that RORgt expression in Tregs contributes to an optimal suppressive capacity during gut (show GUSB Antibodies)-specific immune responses, rendering Foxp3 (show FOXP3 Antibodies)-RORgt T cells as an important effector Treg subset in the intestinal system.
Rag-RORgammat-reporter and Rag KO mice undergoing ischemia reperfusion injury expressed high protein levels of both IL-22 (show IL22 Antibodies) and GFP (RORgammat)
The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known\; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene.
RAR-related orphan nuclear receptor variant 2
, nuclear receptor ROR-gamma
, nuclear receptor RZR-gamma
, nuclear receptor subfamily 1 group F member 3
, retinoic acid-binding receptor gamma
, retinoid-related orphan receptor gamma
, RAR-related orphan receptor gamma
, retinoid-related orphan receptor-gamma
, thymus orphan receptor