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Here we attempt a comprehensive review of the post-translational regulation of RORgammat, an area that holds the potential to transform the way we target the RORgammat/IL-17 (show IL17A Proteins) pathway
CYP11A1 (show CYP11A1 Proteins)- derived hydroxyvitamin D derivatives as "inverse" agonists on ROR-alpha and ROR-gamma.
RORgamma mediates epithelial-mesenchymal transition of hepatocytes during hepatic fibrosis facilitated by TGFbeta1 (show TGFB1 Proteins).
The interaction between c-Maf (show MAF Proteins) and RORgammat, and Blimp-1 (show PRDM1 Proteins).
this review on RORC as a transcription factor required for the generation of type 3 lymphoid cells, which induce the development of lymphoid tissues, provide resistance of epithelial stem cells to injury, maintain homeostasis with the symbiotic microbiota, orchestrate defense against extracellular microbes, and regulate allergic responses
IKKalpha (show CHUK Proteins)-dependent phosphorylation of S376 stimulated whereas IKKalpha (show CHUK Proteins)-independent phosphorylation of S484 inhibited RORgammat function in Th17 differentiation.
There are 2 putative binding motifs for specificity protein transcription factors from the specificity protein/Kruppel-like factor family in the promoter of human RORgammaT. SP2 recognized binding motifs in the human RORgammaT promoter, which was critical for maintaining expression.
Results from the study establish RORgamma as a key player in castration-resistant prostate cancer (CRPCa) by acting upstream of AR and as a new therapeutic target for advanced PCa (show FLVCR1 Proteins).
Data suggest that apo (show C9orf3 Proteins) RORC adopts active conformation capable of recruiting coactivator peptides that stabilize helix 12 of the active state in the absence of a ligand; ligand-bound RORC binds inverse agonists that disrupt critical interactions that stabilize helix 12; helix 12 destabilization in the active state shifts the conformational equilibrium of RORC toward an inactive state.
Retinoid-related orphan receptor (show NR1D2 Proteins) gammat may be associated with NK22 cells in reproduction. Particularly, higher expression of retinoid-related orphan receptor (show NR1D2 Proteins) gammat may be associated with elevated NK22 cells in unexplained recurrent pregnancy loss.
The total frequencies for the combined genotypes for the bGH and RORC genes, which provide for superior meat quality and carcass weight, in the populations of Kazakh white-headed cattle
The role of the orphan receptor (show NR1D2 Proteins) C allele variation on intramuscular fat in beef cattle is reported.
pharmacological inhibition of RORgamma skews TCRalpha gene rearrangement, limits T cell repertoire diversity, and inhibits development of autoimmune encephalomyelitis.targeting RORgammaT not only inhibits Th17 cell development and function but also fundamentally alters thymic-emigrant recognition of self and foreign antigens.
ubiquitination of K446 limits RORgammat-mediated Th17 differentiation by inhibiting the recruitment of coactivator SRC1 (show NCOA1 Proteins)
RORgamma/IL-17A (show IL17A Proteins) axis influences VEGF (show VEGFA Proteins) production and neovascular retinopathy by mechanisms involving neuroglia. Inhibition of RORgamma and IL-17A (show IL17A Proteins) may have potential for the improved treatment of neovascular retinopathies.
secretion of IL-17 (show IL17A Proteins) by biTregs was abrogated completely in FoxP3 (show FOXP3 Proteins)(Cre) x RORC(fl/fl (show FLT3LG Proteins)) mice. Furthermore, Tregs showed a more activated phenotype after cell-specific inactivation of RORgammat signalling. Finally, and remarkably, biTregs were found to potently suppress anti-inflammatory Th2 immunity in a RORgammat-dependent manner.
this study reveales a new mechanism through which procyanidin B2 gallates inhibit IFN-gamma and IL-17 production in T cells by down-regulation of T-bet and RORgammat expression
The data suggest that RORgt expression in Tregs contributes to an optimal suppressive capacity during gut (show GUSB Proteins)-specific immune responses, rendering Foxp3 (show FOXP3 Proteins)-RORgt T cells as an important effector Treg subset in the intestinal system.
Rag-RORgammat-reporter and Rag KO mice undergoing ischemia reperfusion injury expressed high protein levels of both IL-22 (show IL22 Proteins) and GFP (RORgammat)
Epidermal Notch1 (show NOTCH1 Proteins) recruits RORgamma(+) group 3 innate lymphoid cells to orchestrate normal skin repair.
The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known\; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene.
RAR-related orphan nuclear receptor variant 2
, nuclear receptor ROR-gamma
, nuclear receptor RZR-gamma
, nuclear receptor subfamily 1 group F member 3
, retinoic acid-binding receptor gamma
, retinoid-related orphan receptor gamma
, RAR-related orphan receptor gamma
, retinoid-related orphan receptor-gamma
, thymus orphan receptor