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anti-Human Adenylate Kinase 2 Antibodies:
anti-Mouse (Murine) Adenylate Kinase 2 Antibodies:
anti-Rat (Rattus) Adenylate Kinase 2 Antibodies:
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Human Polyclonal Adenylate Kinase 2 Primary Antibody for IHC (p), WB - ABIN392742
Noma, Song, Yoon, Tanaka, Nakazawa: cDNA cloning and tissue-specific expression of the gene encoding human adenylate kinase isozyme 2. in Biochimica et biophysica acta 1998
Show all 3 Pubmed References
Human Polyclonal Adenylate Kinase 2 Primary Antibody for IHC (p), WB - ABIN392741
Lee, Kim, Lee, Kim, Lee, Park, Choe: Cloning and expression of human adenylate kinase 2 isozymes: differential expression of adenylate kinase 1 and 2 in human muscle tissues. in Journal of biochemistry 1998
Show all 3 Pubmed References
Adenylate kinase 2 deficiency limits survival and regulates various genes during larval stages of Drosophila melanogaster.
Data demonstrate that adenylate kinase 2 plays a critical role in adenine nucleotide metabolism in the mitochondrial intermembrane space and is essential for growth.
Reticular dysgenesis-associated AK2 protects hematopoietic stem and progenitor cell development from oxidative stress.
Knockdown of zebrafish ak2 also leads to aberrant leukocyte development, stressing the evolutionarily conserved role of AK2.
In conclusion, our data suggest that SIRPalpha signaling through SHP-2 (show PTPN11 Antibodies)-PI3K (show PIK3CA Antibodies)-Akt2 (show AKT2 Antibodies) strongly influences osteoblast differentiation from bone marrow stromal cells.
AK2 deficiency compromises the mitochondrial energy metabolism required for differentiation of human neutrophil and lymphoid lineages.
results suggest that AK2 is an associated activator of DUSP26 (show DUSP26 Antibodies) and suppresses cell proliferation by FADD (show FADD Antibodies) dephosphorylation, postulating AK2 as a negative regulator of tumour growth.
AK2 is indispensable for neutrophil differentiation, indicating a possible causative link between AK2 deficiency and neutropenia in reticular dysgenesis.
These results suggest that, acting in concert with FADD (show FADD Antibodies) and caspase-10 (show CASP10 Antibodies), AK2 mediates a novel intrinsic apoptotic pathway that may be involved in tumorigenesis.
The alpha-borano or alpha-H on PMEA and PMPA were detrimental to the activity of recombinant human AMP (show APRT Antibodies) kinases 2
Biallelic mutations in AK2 (adenylate kinase 2) in seven individuals affected with reticular dysgenesis and sensorineural deafness, were identified.
The gene encoding the mitochondrial energy metabolism enzyme adenylate kinase 2 (AK2) is mutated in individuals with reticular dysgenesis.
In addition to AK1 (show AK1 Antibodies) and AK2, which we previously demonstrated are present in outer dense fibers (show ODF1 Antibodies) and mitochondrial sheath of the mouse sperm tail, we show that another AK, AK8 (show AK8 Antibodies), is present in a third flagellar compartment, the axoneme.
Adenylate kinase 2 links mitochondrial energy metabolism to the induction of the unfolded protein response.
Reduced Akt2 (show AKT2 Antibodies) leads to up-regulation of Rab4a (show RAB4A Antibodies) expression in cardiomyocytes in a cell-autonomous fashion that may involve activation of PPARalpha (show PPARA Antibodies).
AK2 in the flagellar accessory structures provides a mechanism to buffer the adenylate energy charge for sperm motility. Ak2 protein was localized to the mitochondrial sheath in the sperm midpiece.
Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Three isozymes of adenylate kinase, namely 1, 2, and 3, have been identified in vertebrates\; this gene encodes isozyme 2. Expression of these isozymes is tissue-specific and developmentally regulated. Isozyme 2 is localized in the mitochondrial intermembrane space and may play a role in apoptosis. Mutations in this gene are the cause of reticular dysgenesis. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1 and 2.
, adenylate kinase-2
, adenylate kinase 2
, AK 2
, ATP-AMP transphosphorylase 2
, ATP:AMP phosphotransferase
, adenylate kinase 2, mitochondrial
, adenylate monophosphate kinase
, adenylate kinase isoenzyme 2, mitochondrial
, adenylate kinase isozyme 2