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polyglutamine-induced cell death was dramatically suppressed in flies lacking Dark, the fly homolog of human Apaf-1, a key regulator of apoptosis
structural analysis of Apaf-1 in the auto-inhibited form demonstrates the critical role of ADP [review]
ARK is essential for apoptosis during D. melanogaster development, and for radiation-induced apoptosis. Ark mutant embryos have extra cells, and tissues such as brain lobes and wing discs are enlarged.
Daxx (show DAXX Proteins)-like protein of Drosophila interacts with Dmp53 and affects longevity and Ark mRNA level
A significant correlation between changes in the levels of expression and methylation was detected for the three apoptosis-regulatory genes (APAF1, DAPK1 (show DAPK1 Proteins), and BCL2 (show BCL2 Proteins)). The results suggest that methylation play an important role in the regulation of the apoptosis system genes in breast cancer.
Primary cells derived from patients with diffuse large B cell lymphomas show membrane raft sequestration of the apoptosome adaptor protein, Apaf-1, which may mediate drug resistance.
Loss of APAF-1 expression is associated with early recurrence in stage I-III colorectal cancer, suggesting that APAF-1 may have clinical value as a predictive marker of early recurrence.
the markers Ets-1 and APAF-1 relative to p53, Ki-67 and PTEN expression in colon adenomas/polyps, were investigated.
Different selenium concentrations had varying effects on BAK1 (show BAK1 Proteins) and APAF1 levels. APAF1 may play an important role in the pathogenesis of KBD
miR21 is transferred from cancer-associated adipocytes (CAAs) and fibroblasts (CAFs (show TBX1 Proteins)) to the cancer cells, where it suppresses ovarian cancer apoptosis and confers chemoresistance by binding to its direct novel target, APAF1.
HDAC (show HDAC3 Proteins) inhibitors can induce p53 (show TP53 Proteins) acetylation at lysine 120, which in turn enhances mitochondrion-mediated apoptosis through transcriptional up-regulation of Apaf-1.
Renal APAF1 expression is increased in diabetes and diabetic nephropathy.
Inhibition of Caspase-9 restricted, while Apaf-1 promoted, Chlamydia pneumoniae infection in HEp-2, HeLa, and mouse epithelial fibroblast (MEF) cells.
These results suggest that CED-4 forms a complex with ced-3 mRNA and delivers it to ribosomes for translation.
miR (show MLXIP Proteins)-183 was induced in protective postconditioning and reduced reperfusion injury of the livers via the targeting of apoptotic signaling. miR (show MLXIP Proteins)-183 mediated the tolerance induced by iPoC in livers via Apaf-1 repressing.
Apaf1's pivotal role during embryonic development as has been demonstrated to be in regulation of neuronal cell death
Apaf1 is required for proper cortical neuron differentiation since its deletion specifically impairs axonal outgrowth.
study demonstrates that MMP-3 (show MMP3 Proteins) leads to caspase-9 (show CASP9 Proteins) activation and suggests that this occurs indirectly via a cytosolic protein, possibly involving Apaf-1
results provide evidence that Apaf-1 pharmacological inhibition has therapeutic potential for the treatment of apoptosis-related diseases.
Study reports experimental evidence suggesting the likely participation of the Apaf1 protein in the aggregation of polyQ stretches; Apaf1 may enhance polyglutamine aggregation by reducing the cellular protein levels of available functional Hsp70 (show HSP70 Proteins)
miR (show MLXIP Proteins)-23a/b and miR (show MLXIP Proteins)-27a/b are endogenous inhibitory factors of Apaf-1 expression and regulate the sensitivity of neurons to apoptosis.
a role for Apaf1 at the mitochondria
The Apaf-1-independent caspase (show CASP3 Proteins) activation was not inhibited by Bcl-2 (show BCL2 Proteins), and occurred without the release of cytochrome c (show CYCS Proteins) from mitochondria, suggesting that the mitochondrial pathway was not involved in this death process.
Counterpulsation could protect vascular endothelial cells from apoptosis, delaying early atherosclerotic lesions possibly through transcriptional down-regulation of pro-apoptotic gene Apaf-1, and up-regulation of anti-apoptotic gene BIRC2 (show BIRC2 Proteins).
This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.
, Apaf-1 related killer
, Apaf-1-related killer
, apaf1-related killer
, drosophila Apaf-1-related killer
, lethal (2) SH0173
, transcription unit 1
, apoptotic peptidase activating factor 1
, apoptotic protease-activating factor 1-like
, apoptotic protease-activating factor 1
, apoptotic protease activating factor 1
, forebrain overgrowth