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Human E2F1 Protein expressed in HEK-293 Cells - ABIN2719894
Tarangelo, Lo, Teng, Kim, Le, Watson, Furth, Raman, Ehmer, Viatour: Recruitment of Pontin/Reptin by E2f1 amplifies E2f transcriptional response during cancer progression. in Nature communications 2015
specific alternate transcripts of activator E2F (show E2F2 Proteins), dE2F1, may have a dual function on cell cycle progression and cannot simply be viewed as a pro-proliferative transcription factor
These findings identify a key function of E2F in skeletal muscle required for animal viability, and illustrate how the cell cycle regulator is repurposed in post-mitotic cells.
Mechanistically, miR (show MYLIP Proteins)-998 operates by repressing dCbl, a negative regulator of EGFR (show EGFR Proteins) signaling. Significantly, dCbl is a critical target of miR (show MYLIP Proteins)-998 since dCbl phenocopies the effects of miR (show MYLIP Proteins)-998 on dE2f1-dependent apoptosis in rbf (show ATP5I Proteins) mutants
also demonstrated that an optimum level of dLin52 is needed for dE2F1/2 activity on the hid promoter
Results show that regulation of e2f1 and PCNA (show PCNA Proteins) by DREF (show ZBED1 Proteins) in vivo is complex and the regulation mechanism may differ with the tissue and/or positions in the tissue.
Loss of dE2F compromises mitochondrial function.
Data propose that the interaction between ORC5 (show ORC5 Proteins) and dE2F1 may reflect a feedback mechanism between replication initiation proteins and dE2F1 that ensures that proliferating cells maintain a robust level of replication proteins for the next cell cycle.
results suggest that E2F/DP complexes are essential for all genomic targeting of RBF1
Inappropriate accumulation of E2f1 protein during S phase triggers the elimination of potentially hyperplastic cells via apoptosis in order to ensure normal development of rapidly proliferating tissues.
endocycles of Drosophila are driven by a molecular oscillator in which the E2F1 transcription factor promotes CycE (show CCNE1 Proteins) expression and S-phase initiation, S-phase then activates the CRL4(CDT2) ubiquitin ligase, and this in turn mediates the destruction of E2F1
This study suggests for the first time an involvement of E2F1 copy number variations in testicular germ cell tumor susceptibility and supports previous preliminary data on the importance of AKT (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) signaling pathway in this cancer.
High E2F1 expression is associated with gastric cancer.
Data suggest that the protein arginine methyltransferase 5 (PRMT5 (show PRMT5 Proteins))-E2F1 transcription factor (E2F-1) pathway may act as a common target for exogenous lectins including Anguilla japonica lectin 1 (AJL1), and the cellular response to exogenous AJL1 may suggest a novel agent for cancer gene therapy.
The low level E2F1 are sufficient to induce numerous cell cycle-promoting genes, intermediate levels induce growth arrest genes (i.e., p18 (show CDKN2C Proteins), p19 (show CDKN2D Proteins) and p27 (show PAK2 Proteins)), whereas higher levels are necessary to induce key apoptotic E2F1 targets APAF1 (show APAF1 Proteins), PUMA (show BBC3 Proteins), HRK and BIM (show BCL2L11 Proteins).
This review focuses on the relationship between E2F1, growth factors and cytokines.
that E2F1 mRNA stability and E2F1 protein levels are reduced in cells lacking RALY (show RALY Proteins) expression
our results indicate that E2F1 is an important downstream gene of ISX (show ISX Proteins) in hepatoma progression.
found that human E2F1 competes with YAP (show YAP1 Proteins) for TEAD1 (show TEAD1 Proteins) binding, affecting YAP (show YAP1 Proteins) activity, indicating that this mode of cross-regulation is conserved
E2F1-mediated hPOMC transcription is a potential target for suppressing ACTH (show POMC Proteins) production in ectopic Cushing's syndrome.
Results suggest that E7 recruited CUL2 (show CUL2 Proteins), driven by CUL2 (show CUL2 Proteins)/E2F1/miR (show MLXIP Proteins)-424 regulatory loop, is overexpressed and accelerates HPV16-induced cervical carcinogenesis.
p63alpha protein up-regulates heat shock protein 70 (show HSP70 Proteins) expression via E2F1 transcription factor 1 (show HNF1A Proteins), promoting Wasf3/Wave3 (show WASF3 Proteins)/MMP9 (show MMP9 Proteins) signaling and bladder cancer invasion
The evidence has been presented that the retinoblastoma protein utilizes a cell-cycle-independent interaction with E2F1 to recruit EZH2 (show EZH2 Proteins) to diverse repeat sequences.
germ-line loss of E2f1 or E2f3b, but not E2f3a, protected mice against hepatocellular carcinoma
E2F1 hinders skin wound healing by suppressing VEGF (show VEGFA Proteins) expression, neovascularization, and macrophage recruitment. Strategies that target E2F1 may enhance wound healing.
systems-level control of cell cycle arrest by pRB (show PGR Proteins)-E2F and p27 (show CDKN1B Proteins)-CDK (show CDK4 Proteins) regulation, is reported.
TERT (show TERT Proteins) has a role in neointima formation through epigenetic regulation of proliferative E2F1 target gene expression in smooth muscle cells.
inhibition of PDK4 (show PDK4 Proteins) activity in Hepatocellular carcinoma cells increased cyclin E1 (show CCNE1 Proteins), cyclin A2 (show CCNA2 Proteins), and E2F1 proteins.
Data indicate that adenosine and CGS21680 upregulate CD39 (show ENTPD1 Proteins) and CD73 via E2F-1 and CREB (show CREB1 Proteins).
Expression of Kv10.1 (show KCNG3 Proteins) driven by phosphorylated Rb/E2F1 contributes to G2/M progression of cancer and non-transformed cells.
Spinal cord injury-induced activation of E2F1-2 mediates cell cycle activation, contributing to gliopathy and neuronal/tissue loss associated with motor impairments and post-traumatic hyperesthesia.
Xphb1 represses E2F1 activity.
SIM (show SIM2 Proteins) and SMR1 are involved in hyperphosphorylation of the cell-cycle regulator RBR1 and overexpression of E2F target genes.
S6K1 interacts with retinoblastoma protein RBR via its N-terminal RBR binding motif, promotes its nuclear localization and consequent RBR-dependent repression of cell cycle genes through transcription factor E2FB.
The Arabidopsis (Arabidopsis thaliana) DEL1 gene was identified as a transcriptional target of the classical E2Fb and E2Fc transcription factors.
The authors found that S6K1 associates with the Retinoblastoma-related 1 (RBR1)-E2FB complex and this is partly mediated by its N-terminal LVxCxE motif.
Results suggest that E2FB is one of the key targets for auxin to determine whether cells proliferate or whether they exit the cell cycle, enlarge, and endoreduplicate their DNA.
AtE2Fa and AtE2Fb have specific expression patterns and may play similar but distinct roles during cell cycle progression.
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.
, E2-promoter binding factor
, PRB-binding protein E2F-1
, retinoblastoma-associated protein 1
, retinoblastoma-binding protein 3
, transcription factor E2F1
, E2F-1 transcription factor