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Human HMGB1 Protein expressed in Wheat germ - ABIN1306797
Kuniyasu, Yano, Sasaki, Sasahira, Sone, Ohmori: Colon cancer cell-derived high mobility group 1/amphoterin induces growth inhibition and apoptosis in macrophages. in The American journal of pathology 2005
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Mouse (Murine) HMGB1 Protein expressed in Escherichia coli (E. coli) - ABIN1079871
Ruzzenente, Iacono, Conci, Bertuzzo, Salvagno, Ruzzenente, Campagnaro, Valdegamberi, Pachera, Bagante, Guglielmi: A novel serum marker for biliary tract cancer: diagnostic and prognostic values of quantitative evaluation of serum mucin 5AC (MUC5AC). in Surgery 2014
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Human HMGB1 Protein expressed in Escherichia coli (E. coli) - ABIN987946
Contreras, Friday, Morrison, Hao, Keiper: Cap-independent translation promotes C. elegans germ cell apoptosis through Apaf-1/CED-4 in a caspase-dependent mechanism. in PLoS ONE 2011
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Human HMGB1 Protein expressed in Escherichia coli (E. coli) - ABIN1176814
Maroso, Balosso, Ravizza, Liu, Aronica, Iyer, Rossetti, Molteni, Casalgrandi, Manfredi, Bianchi, Vezzani: Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures. in Nature medicine 2010
Human HMGB1 Protein expressed in Human Cells - ABIN2002577
Wen, Huang, Johnson, Reeck: A human placental cDNA clone that encodes nonhistone chromosomal protein HMG-1. in Nucleic acids research 1989
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Data show that HMGB1 is a direct target of miR (show MLXIP Proteins)-142 in cervical cancer and it is implicated in miR (show MLXIP Proteins)-142-induced cell proliferation, invasiveness and apoptosis of cervical cancer cells.
In addition to the findings that HMGB1 is a sensitive biomarker of allergic asthma in children, data demonstrated a significant correlation between the decrease of HMGB1 levels and a successful treatment response.
miR (show MLXIP Proteins)-193a displayed its role in lung cancer via modulating the HMGB1 expression. This study demonstrated that UCA1 exerts oncogenes activity in lung cancer, acting mechanistically by upregulating HMGB1 expression through 'sponging' miR (show MLXIP Proteins)-193a.
Combined analysis of LC3B (show MAP1LC3B Proteins) puncta and HMGB1 expression allowed for improved stratification of patients with respect to the characteristics of their immune infiltrate as well as overall and metastasis-free survival
Intracolonic application of adeno (show ADORA2A Proteins)-associated virus (AAV)-HMGB1 A box is effective in alleviating murine colitis and has therapeutic potential in human inflammatory bowel diseases (IBDs).
HMGB1 is increased in nasal lavage samples of chronic rhinosinusitis patients; secreted HMGB1 participates in IL-8 (show IL8 Proteins) upregulation mediating inflammatory response
High HMGB1 expression is associated with colorectal cancer.
HMGB1 induced the activation of p38 and nuclear factor-kappaB (NF-kappaB) in TLR4/ primary AVICs, and inhibited p38 and NFkappaB in wildtype AVICs treated with TLR4specific antibodies.
HMGB1 is capable to promote oncogenesis or suppress tumor growth, thus affecting treatment efficacy. [review]
In persons with chronic spinal cord injury, HMGB1 was significantly elevated, compared with uninjured persons.
Systemic HMGB-1 levels were significantly elevated in both trauma groups when compared to the sham group. Haemorrhagic shock severity and duration were positively correlated with HMGB-1 levels and compared to baseline values, concentrations remained significantly increased in severe hemorrhage when compared to moderate hemorrhage.
high levels of HMGB1 in the small intestine and its relation to high levels of HMGB1 in plasma of piglets infected with E. coli O55 that suffered from infection correlated with high levels of inflammatory cytokines and bacterial translocation; levels were higher than HMGB1 levels in piglets with mild clinical symptoms
HMGB-1 may participate in the inflammatory response and liver injury in the late stage of acute liver failure
HMGB1 can act as an adjuvant in modulating the bovine immune system and thus lays a foundation for using HMGB1 as an adjuvant in various bovine vaccine preparations.
Single-nucleotide polymorphism in the 3'-untranslated region of the HMGB1 gene affects the binding of target bta-miR (show MYLIP Proteins)-223 and is involved in mastitis.
The mechanisms of interaction of the non-histone chromosomal protein (show HMGB2 Proteins) HMGB1 and linker histone H1 (show H1F0 Proteins) with DNA have been studied using circular dichroism and absorption spectroscopy.
HMGB1 is able to induce considerable changes in DNA structure upon binding even when the amount of the protein directly associated with DNA is low
Interaction between non-histone chromatin protein HMGB1 and linker histone H1 (show H1F0 Proteins)
HMGB-1 might play a role in the pathological thickening of subchondral bone plate/osteophyte formation.
Analysis of mechanical response generated by binding of DNA-bending protein HMGB1 to single tethered 48.5 kb lambda-DNA molecules finds that compaction of DNA increases with increasing HMGB1 concentration.
Thrombomoduln not only binds to HMGB1 but also aids the proteolytic cleavage of HMGB1 by thrombin (show F2 Proteins).
Here, the authors show that RAGE (show AGER Proteins) deficiency impairs anti-viral immunity during an early-life infection with pneumonia virus of mice (PVM; a murine analogue of RSV). The elevated viral load was associated with the release of high mobility group box-1 (HMGB1) which triggered airway smooth muscle remodelling in early-life.
HMGB1 is expressed and secreted from intestinal epithelial cells in response to Wnt (show WNT2 Proteins) signalling activation. This secreted HMGB1 is required to maintain nearly all aspects of the crypt progenitor phenotype observed following Apc (show APC Proteins) loss and add to the body of accumulating evidence indicating that targeting HMGB1 may be a viable novel therapeutic approach.
Our data suggest that, apart from the role of D3, TMalpha and TM's D123 (show CDC123 Proteins) require both lectin-like D1 capable of sequestering HMGB1 and EGF (show EGF Proteins)-like D2 responsible for thrombin (show F2 Proteins)-dependent degradation of HMGB1, in abolishing the allodynia caused by exogenous or endogenous HMGB1.
Anti-HMGB1 autoimmunity may potentially play a role in atherogenesis in Apoe (show APOE Proteins)(-/-) mice
These results suggest that HMGB1-modulated TLR5 (show TLR5 Proteins) signaling is responsible for pain hypersensitivity.
mip-2 (show CXCL2 Proteins) siRNA and an anti-MIP-2 (show CXCL2 Proteins) antibody significantly reduced the expression levels of Ccl-2 (show CCL2 Proteins), TLR-4 (show TLR4 Proteins), iNOS (show NOS2 Proteins), IL-6 (show IL6 Proteins), IL-1beta (show IL1B Proteins), HMGB1, and TNF-alpha (show TNF Proteins) in RAW264.7 cells exposed tolipopolysaccharide.
We concluded that fusion of HMGB1 with GFP was immunologically more effective than GFP alone.
HMGB-1 is a late inflammatory mediator of sepsis.
HMGB1 activates the NF-kappaB (show NFKB1 Proteins) and JNK (show MAPK8 Proteins)/p38 (show CRK Proteins) pathways through TLR4 (show TLR4 Proteins)/MyD88 (show MYD88 Proteins)-dependent signaling and induces an inflammatory response in lungs exposed to cigarette smoke.
Data demonstrate that inhibition of HMGB1 reduced inflammatory mediators, leading to increased insulin receptor (show INSR Proteins) signal transduction in retinal endothelial cells grown in high glucose. Secondly, use of glycyrrhizin was an effective therapy against ischemia-reperfusion-induced retinal neuronal and vascular damage.
High mobility group box-1 and nucleosomes might have use as biomarkers for horses with gastrointestinal disease.
Extracellular HMGB-1 is widespread only in synovial membrane from diseased joints in horses with osteoarthritis.
Osteochondral injury was associated with a significant increase in synovial HMGB-1 concentrations in horses with joint injuries, compared with results for clinically normal horses.
Airway pressure release ventilation reduces bronchoalveolar lavage fluid HMGB1 levels and lung water, preserving oxygenation and systemic blood pressure in experimental acute respiratory distress syndrome.
SCARA5 (show SCARA5 Proteins) is an HMGB1 recognition receptor that is negatively involved in HMGB1-mediated inflammation in pufferfish (Tetraodon nigroviridis) and zebrafish (Danio rerio) models.
HMGB1 is a critical factor for brain development, enabling survival and proliferation of neural progenitors that will form the forebrain structures.
a transcriptional regulator that may play a central role in the stabilization and/or assembly of several multifunctional complexes through protein-protein interactions
high-mobility group box 1
, high mobility group protein 1
, sulfoglucuronyl carbohydrate binding protein
, High mobility group protein B1
, high mobility group protein B1
, Sulfoglucuronyl carbohydrate binding protein
, high-mobility group (nonhistone chromosomal) protein 1
, non-histone protein HMG1
, heparin-binding protein p30
, high mobility group 1
, high mobility group protein B1-like protein
, high mobility group 1 protein
, high mobility group protein HMG1
, high mobility group protein B1-like
, High mobility group protein 1
, high mobility group box 1
, HMG box transcription factor 1
, HMG box-containing protein 1
, HMG-box containing protein 1
, high mobility group box transcription factor 1