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Human HMGB1 Protein expressed in Wheat germ - ABIN1306797
Kuniyasu, Yano, Sasaki, Sasahira, Sone, Ohmori: Colon cancer cell-derived high mobility group 1/amphoterin induces growth inhibition and apoptosis in macrophages. in The American journal of pathology 2005
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Human HMGB1 Protein expressed in Escherichia coli (E. coli) - ABIN987946
Contreras, Friday, Morrison, Hao, Keiper: Cap-independent translation promotes C. elegans germ cell apoptosis through Apaf-1/CED-4 in a caspase-dependent mechanism. in PLoS ONE 2011
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Mouse (Murine) HMGB1 Protein expressed in Escherichia coli (E. coli) - ABIN1079871
Ruzzenente, Iacono, Conci, Bertuzzo, Salvagno, Ruzzenente, Campagnaro, Valdegamberi, Pachera, Bagante, Guglielmi: A novel serum marker for biliary tract cancer: diagnostic and prognostic values of quantitative evaluation of serum mucin 5AC (MUC5AC). in Surgery 2014
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Human HMGB1 Protein expressed in Escherichia coli (E. coli) - ABIN1176814
Maroso, Balosso, Ravizza, Liu, Aronica, Iyer, Rossetti, Molteni, Casalgrandi, Manfredi, Bianchi, Vezzani: Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures. in Nature medicine 2010
Human HMGB1 Protein expressed in Human Cells - ABIN2002577
Wen, Huang, Johnson, Reeck: A human placental cDNA clone that encodes nonhistone chromosomal protein HMG-1. in Nucleic acids research 1989
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HMGB1 signaling pathways may be more easily activated in elderly coronary artery disease patients with concomitant inflammatory rheumatic disease and trigger a detrimental inflammatory process causing severe cardiovascular problems.
In-depth IPA analysis revealed that CENPU (show MLF1IP Proteins) was associated with the HMGB1 signaling pathway. qPCR and western blot analysis demonstrated that in the HMGB1 signaling pathway, CENPU (show MLF1IP Proteins) knockdown downregulated expression levels of ILB, CXCL8 (show IL8 Proteins), RAC1 and IL1A (show IL1A Proteins)
HMGB1 may be a necessary intermediate in the ceramide-dependent metabolic consequences of cigarette smoke exposure.
HMGB1 amplified neutrophil activation and the activation and injury of glomerular endothelial cells in the presence of antineutrophil cytoplasmic antibody .
HMGB1 is over-expressed in chronic middle-ear pathologies and may play a role in the progression of the inflammatory process from recurrent acute otitis media to chronic suppurative otitis media.
High mobility group box 1 (HMGB1) has been proposed as biomarker potentially able to elucidate the causative relationship between the immune system and gut (show GUSB Proteins) mucosal inflammation and onset and progression of gastrointestinal diseases.
Data revealed an increased risk of oral squamous cell carcinoma (OSCC) among patients with the HMGB1 polymorphism rs1045411 C/C compared with those with the C/T or C/T+T/T genotype and confirms the association of rs1045411 in the HMGB1 3'-UTR region with OSCC risk most likely because a putative miRNA-505 binding site.
These findings demonstrate that released HMGB1 is central to DS, and that targeting HMGB1 may be of therapeutic value in the treatment of DS.
HMGB1 overexpression is associated with poorer prognosis in patients with various types of cancer, suggesting that it is a prognostic factor and potential biomarker for survival in cancer [review and meta-analysis]
High-Mobility Group Box 1 Upregulates MUC5AC and MUC5B Expression in Primary Airway Epithelial Cells.
It is possible that JNK (show MAPK8 Proteins) and TNF-alpha (show TNF Proteins) commonly contribute to kidney damage by assembling a positive feedback cycle after crush syndrome, leading to increased apoptosis in the renal cortex. HMGB1 from the muscle may be the trigger.
Here, we show that cabozantinib rapidly eradicates invasive, poorly differentiated PTEN/p53 (show TP53 Proteins)-deficient murine prostate cancer. This was associated with enhanced release of neutrophil chemotactic factors from tumor cells, including CXCL12 (show CXCL12 Proteins) and HMGB1, resulting in robust infiltration of neutrophils into the tumor.
OVA-induced allergic lung inflammation altered redox status concomitantly with impaired lung function, which was associated with HMGB1 expression and proteolytic remodeling.
Here, the authors show that RAGE (show AGER Proteins) deficiency impairs anti-viral immunity during an early-life infection with pneumonia virus of mice (PVM; a murine analogue of RSV). The elevated viral load was associated with the release of high mobility group box-1 (HMGB1) which triggered airway smooth muscle remodelling in early-life.
HMGB1 is expressed and secreted from intestinal epithelial cells in response to Wnt (show WNT2 Proteins) signalling activation. This secreted HMGB1 is required to maintain nearly all aspects of the crypt progenitor phenotype observed following Apc (show APC Proteins) loss and add to the body of accumulating evidence indicating that targeting HMGB1 may be a viable novel therapeutic approach.
Our data suggest that, apart from the role of D3, TMalpha and TM's D123 (show CDC123 Proteins) require both lectin-like D1 capable of sequestering HMGB1 and EGF (show EGF Proteins)-like D2 responsible for thrombin (show F2 Proteins)-dependent degradation of HMGB1, in abolishing the allodynia caused by exogenous or endogenous HMGB1.
Anti-HMGB1 autoimmunity may potentially play a role in atherogenesis in Apoe (show APOE Proteins)(-/-) mice
These results suggest that HMGB1-modulated TLR5 (show TLR5 Proteins) signaling is responsible for pain hypersensitivity.
mip-2 (show CXCL2 Proteins) siRNA and an anti-MIP-2 (show CXCL2 Proteins) antibody significantly reduced the expression levels of Ccl-2 (show CCL2 Proteins), TLR-4 (show TLR4 Proteins), iNOS (show NOS2 Proteins), IL-6 (show IL6 Proteins), IL-1beta (show IL1B Proteins), HMGB1, and TNF-alpha (show TNF Proteins) in RAW264.7 cells exposed tolipopolysaccharide.
We concluded that fusion of HMGB1 with GFP was immunologically more effective than GFP alone.
HMGB1 can act as an adjuvant in modulating the bovine immune system and thus lays a foundation for using HMGB1 as an adjuvant in various bovine vaccine preparations.
Single-nucleotide polymorphism in the 3'-untranslated region of the HMGB1 gene affects the binding of target bta-miR (show MYLIP Proteins)-223 and is involved in mastitis.
The mechanisms of interaction of the non-histone chromosomal protein (show HMGB2 Proteins) HMGB1 and linker histone H1 (show H1F0 Proteins) with DNA have been studied using circular dichroism and absorption spectroscopy.
HMGB1 is able to induce considerable changes in DNA structure upon binding even when the amount of the protein directly associated with DNA is low
Interaction between non-histone chromatin protein HMGB1 and linker histone H1 (show H1F0 Proteins)
HMGB-1 might play a role in the pathological thickening of subchondral bone plate/osteophyte formation.
Analysis of mechanical response generated by binding of DNA-bending protein HMGB1 to single tethered 48.5 kb lambda-DNA molecules finds that compaction of DNA increases with increasing HMGB1 concentration.
Thrombomoduln not only binds to HMGB1 but also aids the proteolytic cleavage of HMGB1 by thrombin (show F2 Proteins).
SCARA5 (show SCARA5 Proteins) is an HMGB1 recognition receptor that is negatively involved in HMGB1-mediated inflammation in pufferfish (Tetraodon nigroviridis) and zebrafish (Danio rerio) models.
HMGB1 is a critical factor for brain development, enabling survival and proliferation of neural progenitors that will form the forebrain structures.
Systemic HMGB-1 levels were significantly elevated in both trauma groups when compared to the sham group. Haemorrhagic shock severity and duration were positively correlated with HMGB-1 levels and compared to baseline values, concentrations remained significantly increased in severe hemorrhage when compared to moderate hemorrhage.
high levels of HMGB1 in the small intestine and its relation to high levels of HMGB1 in plasma of piglets infected with E. coli O55 that suffered from infection correlated with high levels of inflammatory cytokines and bacterial translocation; levels were higher than HMGB1 levels in piglets with mild clinical symptoms
HMGB-1 may participate in the inflammatory response and liver injury in the late stage of acute liver failure
High mobility group box-1 and nucleosomes might have use as biomarkers for horses with gastrointestinal disease.
Extracellular HMGB-1 is widespread only in synovial membrane from diseased joints in horses with osteoarthritis.
Osteochondral injury was associated with a significant increase in synovial HMGB-1 concentrations in horses with joint injuries, compared with results for clinically normal horses.
Airway pressure release ventilation reduces bronchoalveolar lavage fluid HMGB1 levels and lung water, preserving oxygenation and systemic blood pressure in experimental acute respiratory distress syndrome.
heparin binding protein that facilitates neurite outgrowth
, Sulfoglucuronyl carbohydrate binding protein
, high mobility group protein 1
, high mobility group protein B1
, high-mobility group (nonhistone chromosomal) protein 1
, high-mobility group box 1
, sulfoglucuronyl carbohydrate binding protein
, high mobility group box 1
, high mobility group 1 protein
, high mobility group protein HMG1
, non-histone protein HMG1
, high mobility group protein B1-like protein
, High mobility group protein B1
, high mobility group protein B1-like
, High mobility group protein 1
, heparin-binding protein p30
, high mobility group 1