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Human HMGB1 Protein expressed in Wheat germ - ABIN1306797
Kuniyasu, Yano, Sasaki, Sasahira, Sone, Ohmori: Colon cancer cell-derived high mobility group 1/amphoterin induces growth inhibition and apoptosis in macrophages. in The American journal of pathology 2005
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Human HMGB1 Protein expressed in Escherichia coli (E. coli) - ABIN987946
Contreras, Friday, Morrison, Hao, Keiper: Cap-independent translation promotes C. elegans germ cell apoptosis through Apaf-1/CED-4 in a caspase-dependent mechanism. in PLoS ONE 2011
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Mouse (Murine) HMGB1 Protein expressed in Escherichia coli (E. coli) - ABIN1079871
Ruzzenente, Iacono, Conci, Bertuzzo, Salvagno, Ruzzenente, Campagnaro, Valdegamberi, Pachera, Bagante, Guglielmi: A novel serum marker for biliary tract cancer: diagnostic and prognostic values of quantitative evaluation of serum mucin 5AC (MUC5AC). in Surgery 2014
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Human HMGB1 Protein expressed in Human Cells - ABIN2002577
Wen, Huang, Johnson, Reeck: A human placental cDNA clone that encodes nonhistone chromosomal protein HMG-1. in Nucleic acids research 1989
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Human HMGB1 Protein expressed in Escherichia coli (E. coli) - ABIN1176814
Maroso, Balosso, Ravizza, Liu, Aronica, Iyer, Rossetti, Molteni, Casalgrandi, Manfredi, Bianchi, Vezzani: Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures. in Nature medicine 2010
hypoxia affects tumour growth and metastasis in melanoma and depict HMGB1 as a potential therapeutic target.
Our study suggests that HMGB1 CSF (show CSF2 Proteins) levels are increased in patients with anti-NMDAR (show GRIN1 Proteins) encephalitis
Our data suggest that HMGB1 regionally secreted by macrophages mediates pancreatic pain by targeting RAGE (show AGER Proteins) and CXCL12 (show CXCL12 Proteins)/CXCR4 (show CXCR4 Proteins) axis in the early stage of acute pancreatitis
A potential link among HMGB1 and vascular adhesion protein-1 (show AOC3 Proteins), oxidative stress, and heme oxygenase-1 (show HMOX1 Proteins) in the pathogenesis of inflammation and angiogenesis associated with proliferative diabetic retinopathy.
CT or CC+CT heterozygotes of the HMGB1 rs1045411 polymorphism reduced the risks for lung cancer, while the G/T/C haplotypes of three HMGB1 SNPs (rs1360485, rs1045411 and rs2249825) also reduced the risk for lung cancer by almost half (0.486-fold) in the Chinese Han population.
There was no direct correlation between CSF (show CSF2 Proteins) and serum levels of HMGB1. Serum HMGB1 cannot be used as a surrogate measure for CSF (show CSF2 Proteins) levels. CSF (show CSF2 Proteins) HMGB1 was elevated in neurological infection/inflammation and Rasmussen's encephalitis
the increased expression of HMGB1 in the placenta may be associated with the pathogenesis of placenta previa by regulating the expression of the proangiogenic factor VEGF (show VEGFA Proteins).
High mobility group box-1 (HMGB1) expression level correlated inversely with tumor differentiation In hepatocellular carcinoma (HCC (show FAM126A Proteins)).
PCAT-1 repressed inhibitory effect of miR (show MLXIP Proteins)-129-5p and reverse high mobility group box 1 (HMGB1) expression, a target gene of miR (show MLXIP Proteins)-129-5p.
chemically-mimicked hypoxia induced nucleocytoplasmic relocation and release of HMGB1 peptides, which in turn up-regulated the production of angiofibrogenic factors in RPE (show RPE Proteins) cells, thereby contributing to the pathogenesis of hypoxia-associated diabetic retinopathies. Conversely, blockades of intraocular HMGB1 bioavailability or signal activation may prevent angiofibrogenesis in development of diabetic retinopathy.
Chloroquine improves the response to ischemic muscle injury and increases HMGB1 after arterial ligation.
Data suggest high mobility group box 1 (HMGB1) expression may be associated with the protective effect of saquinavir (SQV).
Study shows that the disulfide form of high mobility group box-1 mediates bladder pain directly (not secondary to inflammation or injury) through activation of toll-like receptor 4 (show TLR4 Proteins) receptors in the bladder.
findings suggest that HMGB1 induces the transcytosis of albumin (show ALB Proteins) via RAGE (show AGER Proteins)-dependent Src (show SRC Proteins) phosphorylation and Cav-1 (show CAV1 Proteins) phosphorylation. These studies revealed a new mechanism of HMGB1-induced endothelial hyperpermeability.
The injury resistance in the setting of liver fibrosis is accompanied by the inhibition of HMGB1 translocation and release as well as the suppression of HMGB1-related proinflammatory immune responses.
These data demonstrate that 2% H2 inhalation may be a promising therapeutic strategy for intestinal injuries caused by severe sepsis through the regulation of HO-1 (show HMOX1 Proteins) and HMGB1 release. In addition, Nrf2 (show NFE2L2 Proteins) plays a key role in the protective effects of H2 against intestinal damage in this disease.
Lipopolysaccharidestimulation significantly upregulated HMGB1 secretion via the cJun (show JUN Proteins) Nterminal kinase (JNK (show MAPK8 Proteins)) signaling pathway in RAW264.7 macrophages.
HMGB1 oxidation increases during sepsis and enhances HMGB1's pro-inflammatory signaling.
HMGB1/TLR2 activates an autocrine trophic signaling pathways in OLs.
HMGB1 can act as an adjuvant in modulating the bovine immune system and thus lays a foundation for using HMGB1 as an adjuvant in various bovine vaccine preparations.
Single-nucleotide polymorphism in the 3'-untranslated region of the HMGB1 gene affects the binding of target bta-miR (show MYLIP Proteins)-223 and is involved in mastitis.
The mechanisms of interaction of the non-histone chromosomal protein (show HMGB2 Proteins) HMGB1 and linker histone H1 (show H1F0 Proteins) with DNA have been studied using circular dichroism and absorption spectroscopy.
HMGB1 is able to induce considerable changes in DNA structure upon binding even when the amount of the protein directly associated with DNA is low
Interaction between non-histone chromatin protein HMGB1 and linker histone H1 (show H1F0 Proteins)
HMGB-1 might play a role in the pathological thickening of subchondral bone plate/osteophyte formation.
Analysis of mechanical response generated by binding of DNA-bending protein HMGB1 to single tethered 48.5 kb lambda-DNA molecules finds that compaction of DNA increases with increasing HMGB1 concentration.
Thrombomoduln not only binds to HMGB1 but also aids the proteolytic cleavage of HMGB1 by thrombin (show F2 Proteins).
SCARA5 (show SCARA5 Proteins) is an HMGB1 recognition receptor that is negatively involved in HMGB1-mediated inflammation in pufferfish (Tetraodon nigroviridis) and zebrafish (Danio rerio) models.
HMGB1 is a critical factor for brain development, enabling survival and proliferation of neural progenitors that will form the forebrain structures.
Systemic HMGB-1 levels were significantly elevated in both trauma groups when compared to the sham group. Haemorrhagic shock severity and duration were positively correlated with HMGB-1 levels and compared to baseline values, concentrations remained significantly increased in severe hemorrhage when compared to moderate hemorrhage.
high levels of HMGB1 in the small intestine and its relation to high levels of HMGB1 in plasma of piglets infected with E. coli O55 that suffered from infection correlated with high levels of inflammatory cytokines and bacterial translocation; levels were higher than HMGB1 levels in piglets with mild clinical symptoms
HMGB-1 may participate in the inflammatory response and liver injury in the late stage of acute liver failure
High mobility group box-1 and nucleosomes might have use as biomarkers for horses with gastrointestinal disease.
Extracellular HMGB-1 is widespread only in synovial membrane from diseased joints in horses with osteoarthritis.
Osteochondral injury was associated with a significant increase in synovial HMGB-1 concentrations in horses with joint injuries, compared with results for clinically normal horses.
Airway pressure release ventilation reduces bronchoalveolar lavage fluid HMGB1 levels and lung water, preserving oxygenation and systemic blood pressure in experimental acute respiratory distress syndrome.
heparin binding protein that facilitates neurite outgrowth
, Sulfoglucuronyl carbohydrate binding protein
, high mobility group protein 1
, high mobility group protein B1
, high-mobility group (nonhistone chromosomal) protein 1
, high-mobility group box 1
, sulfoglucuronyl carbohydrate binding protein
, high mobility group box 1
, high mobility group 1 protein
, high mobility group protein HMG1
, non-histone protein HMG1
, high mobility group protein B1-like protein
, High mobility group protein B1
, high mobility group protein B1-like
, High mobility group protein 1
, heparin-binding protein p30
, high mobility group 1