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Human HMGB1 Protein expressed in Wheat germ - ABIN1306797
Kuniyasu, Yano, Sasaki, Sasahira, Sone, Ohmori: Colon cancer cell-derived high mobility group 1/amphoterin induces growth inhibition and apoptosis in macrophages. in The American journal of pathology 2005
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Mouse (Murine) HMGB1 Protein expressed in Escherichia coli (E. coli) - ABIN1079871
Ruzzenente, Iacono, Conci, Bertuzzo, Salvagno, Ruzzenente, Campagnaro, Valdegamberi, Pachera, Bagante, Guglielmi: A novel serum marker for biliary tract cancer: diagnostic and prognostic values of quantitative evaluation of serum mucin 5AC (MUC5AC). in Surgery 2014
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Human HMGB1 Protein expressed in Escherichia coli (E. coli) - ABIN987946
Contreras, Friday, Morrison, Hao, Keiper: Cap-independent translation promotes C. elegans germ cell apoptosis through Apaf-1/CED-4 in a caspase-dependent mechanism. in PLoS ONE 2011
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Human HMGB1 Protein expressed in Escherichia coli (E. coli) - ABIN1176814
Maroso, Balosso, Ravizza, Liu, Aronica, Iyer, Rossetti, Molteni, Casalgrandi, Manfredi, Bianchi, Vezzani: Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures. in Nature medicine 2010
Human HMGB1 Protein expressed in Human Cells - ABIN2002577
Wen, Huang, Johnson, Reeck: A human placental cDNA clone that encodes nonhistone chromosomal protein HMG-1. in Nucleic acids research 1989
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HMGB1 is a newly identified gene overexpressed in ovarian cancer and associated with poor clinicopathologic features.
Low HMGB1 expression is associated with myocardial fibrosis.
These results indicate that HMGB1 is a newly identified gene associated with ovarian cancer growth and metastasis
These data suggest that an immediate increase in HMGB1 levels correlates with improved outcome in early breast cancer patients receiving neoadjuvant chemotherapy, and may be a valuable complementary biomarker for early estimation of prognosis.
autophagic CAFs (show TBX1 Proteins) released high-mobility group box 1 (HMGB1), which activated its receptor, Toll (show TLR4 Proteins)-like receptor (TLR) 4 (show TLR4 Proteins), expressed by luminal breast cancer cells, to enhance their stemness and tumourigenicity
High HMGB1 expression is associated with preeclampsia.
Buerger's patients had a significant increase in circulating HMGB-1, MMP-9 (show MMP9 Proteins) and ICAM-1 (show ICAM1 Proteins).
High HMGB1 expression is associated with mesothelioma.
The data indicate that HMGB1-miR (show MLXIP Proteins)-522-3p-PTGR1 (show PTGR1 Proteins) axis may be involved in the abnormal resolution of inflammation and suggest that this mechanism might be a target for modulation of chronic inflammatory disorder.
There was no significant difference in plasma levels of sRAGE or HMGB1 between pAPS (show PAPSS1 Proteins) patients and HCs (show HLCS Proteins). Plasma levels of sRAGE/HMGB1 could not be utilized to differentiate between APA (show ENPEP Proteins)+SLE and APS (show SH2B2 Proteins)+SLE patients
Systemic HMGB-1 levels were significantly elevated in both trauma groups when compared to the sham group. Haemorrhagic shock severity and duration were positively correlated with HMGB-1 levels and compared to baseline values, concentrations remained significantly increased in severe hemorrhage when compared to moderate hemorrhage.
high levels of HMGB1 in the small intestine and its relation to high levels of HMGB1 in plasma of piglets infected with E. coli O55 that suffered from infection correlated with high levels of inflammatory cytokines and bacterial translocation; levels were higher than HMGB1 levels in piglets with mild clinical symptoms
HMGB-1 may participate in the inflammatory response and liver injury in the late stage of acute liver failure
HMGB1 can act as an adjuvant in modulating the bovine immune system and thus lays a foundation for using HMGB1 as an adjuvant in various bovine vaccine preparations.
Single-nucleotide polymorphism in the 3'-untranslated region of the HMGB1 gene affects the binding of target bta-miR (show MYLIP Proteins)-223 and is involved in mastitis.
The mechanisms of interaction of the non-histone chromosomal protein (show HMGB2 Proteins) HMGB1 and linker histone H1 (show H1F0 Proteins) with DNA have been studied using circular dichroism and absorption spectroscopy.
HMGB1 is able to induce considerable changes in DNA structure upon binding even when the amount of the protein directly associated with DNA is low
Interaction between non-histone chromatin protein HMGB1 and linker histone H1 (show H1F0 Proteins)
HMGB-1 might play a role in the pathological thickening of subchondral bone plate/osteophyte formation.
Analysis of mechanical response generated by binding of DNA-bending protein HMGB1 to single tethered 48.5 kb lambda-DNA molecules finds that compaction of DNA increases with increasing HMGB1 concentration.
Thrombomoduln not only binds to HMGB1 but also aids the proteolytic cleavage of HMGB1 by thrombin (show F2 Proteins).
mip-2 (show CXCL2 Proteins) siRNA and an anti-MIP-2 (show CXCL2 Proteins) antibody significantly reduced the expression levels of Ccl-2 (show CCL2 Proteins), TLR-4 (show TLR4 Proteins), iNOS (show NOS2 Proteins), IL-6 (show IL6 Proteins), IL-1beta (show IL1B Proteins), HMGB1, and TNF-alpha (show TNF Proteins) in RAW264.7 cells exposed tolipopolysaccharide.
We concluded that fusion of HMGB1 with GFP was immunologically more effective than GFP alone.
HMGB-1 is a late inflammatory mediator of sepsis.
HMGB1 activates the NF-kappaB (show NFKB1 Proteins) and JNK (show MAPK8 Proteins)/p38 (show CRK Proteins) pathways through TLR4 (show TLR4 Proteins)/MyD88 (show MYD88 Proteins)-dependent signaling and induces an inflammatory response in lungs exposed to cigarette smoke.
Data demonstrate that inhibition of HMGB1 reduced inflammatory mediators, leading to increased insulin receptor (show INSR Proteins) signal transduction in retinal endothelial cells grown in high glucose. Secondly, use of glycyrrhizin was an effective therapy against ischemia-reperfusion-induced retinal neuronal and vascular damage.
results strongly implicate the HMGB1-TLR2/4 axis in the activation of microglia following multiple cortical spreading depression inductions
Zingerone reduces release of HMGB1, sepsis-related mortality, and tissue injury in cecal ligation/puncture model of sepsis.
Platelet-derived disulfide HMGB1 is a central mediator of the sterile inflammatory process in venous thrombosis and could be an attractive target for an anti-inflammatory approach for DVT prophylaxis.
The HMGB1/TLR4 (show TLR4 Proteins)/NF-kappaB (show NFKB1 Proteins) signaling pathway plays an important role in the pathogenesis of asthma.
HMGB1 significantly promoted secretion of matrix vesicles from macrophages and subsequently led to mineral deposition in elevated Calcium/Phosphate medium in vitro.
High mobility group box-1 and nucleosomes might have use as biomarkers for horses with gastrointestinal disease.
Extracellular HMGB-1 is widespread only in synovial membrane from diseased joints in horses with osteoarthritis.
Osteochondral injury was associated with a significant increase in synovial HMGB-1 concentrations in horses with joint injuries, compared with results for clinically normal horses.
Airway pressure release ventilation reduces bronchoalveolar lavage fluid HMGB1 levels and lung water, preserving oxygenation and systemic blood pressure in experimental acute respiratory distress syndrome.
SCARA5 (show SCARA5 Proteins) is an HMGB1 recognition receptor that is negatively involved in HMGB1-mediated inflammation in pufferfish (Tetraodon nigroviridis) and zebrafish (Danio rerio) models.
HMGB1 is a critical factor for brain development, enabling survival and proliferation of neural progenitors that will form the forebrain structures.
a transcriptional regulator that may play a central role in the stabilization and/or assembly of several multifunctional complexes through protein-protein interactions
high-mobility group box 1
, high mobility group protein 1
, sulfoglucuronyl carbohydrate binding protein
, High mobility group protein B1
, high mobility group protein B1
, Sulfoglucuronyl carbohydrate binding protein
, high-mobility group (nonhistone chromosomal) protein 1
, non-histone protein HMG1
, heparin-binding protein p30
, high mobility group 1
, high mobility group protein B1-like protein
, high mobility group 1 protein
, high mobility group protein HMG1
, high mobility group protein B1-like
, High mobility group protein 1
, high mobility group box 1
, HMG box transcription factor 1
, HMG box-containing protein 1
, HMG-box containing protein 1
, high mobility group box transcription factor 1