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Our study highlights the underlying mechanism of cross interaction between ASCs and breast cancer cells, and indicates that PAG1/Cbp in breast cancer cell may modulate tumor progression and acquired chemoresistance in the ASCs-associated breast cancer microenvironment through Src (show SRC ELISA Kits) and AKT (show AKT1 ELISA Kits)/mTOR (show FRAP1 ELISA Kits) pathways.
Up-regulated expression of CBP (show CREBBP ELISA Kits) in Jurkat cells could reduce cell homogeneity and promote cell apoptosis
No association Pag1 mutation with patient with Schizophrenia.
The risk-associated allele of rs2370615 predisposes to allergic disease by increasing PAG1 expression, which might promote B cell activation (show BLNK ELISA Kits) and have a pro-inflammatory effect.
CBP (show CREBBP ELISA Kits) may decrease the metastasis of esophageal carcinoma by inhibiting the activation of Src (show SRC ELISA Kits).
The inhibitory function of novobiocin in disrupting the HIF1alpha (show HIF1A ELISA Kits)/p300 (show EP300 ELISA Kits) complex might be important in tumor cell growth.
siRNA directed against PAG1 in a radioresistant (Hep-2max) cell line dramatically enhanced the radiosensitivity and IR-induced cell death.
expression of CBP (show CREBBP ELISA Kits) gene is decreased in esophageal carcinoma, which might contribute to the tumorigenesis and progression.
An over-expression of PAG1 in PC-3M-1E8 cells effectively suppresses the activation of Ras and ERK (show EPHB2 ELISA Kits), as well as the cyclin D1 (show CCND1 ELISA Kits) expression, leading to an inhibition of the proliferation ability of tumor cells.
Cbp (show CREBBP ELISA Kits) down-regulation is primarily mediated by epigenetic histone modifications via oncogenic MAPK (show MAPK1 ELISA Kits)/PI3K (show PIK3CA ELISA Kits) pathways in a subset of cancer cells.
Inducible knockdown of PAPP-A (show PAPPA ELISA Kits) gene expression in adult female mice extends life span.
Intrinsic mitochondrial oxidative capacity was significantly increased in skeletal muscle of aged PAPP-A (show PAPPA ELISA Kits) KO compared to WT mice. Moreover, 18-month-old PAPP-A (show PAPPA ELISA Kits) KO mice exhibited significantly enhanced endurance running on a treadmill. Thus, PAPP-A (show PAPPA ELISA Kits) deficiency in mice is associated with indices of healthy skeletal muscle function with age.
our findings illustrate that Cbp (show CREBBP ELISA Kits) is an important regulator of Csk (show CSK ELISA Kits) recruitment to the SFK Lyn (show LYN ELISA Kits) in Eporesponsive erythroid cells.
Snell, GHKRO, and PAPPA (show PAPPA ELISA Kits)-KO mice express high levels of two proteins involved in DNA repair, O-6-methylguanine-DNA methyltransferase (MGMT (show MGMT ELISA Kits)) and N-myc downstream-regulated gene 1 (NDRG1 (show NDRG1 ELISA Kits)).
STC2 (show STC2 ELISA Kits) is involved in regulating PAPP-A (show PAPPA ELISA Kits) activity during the development of atherosclerosis
Study demonstrates proof-of-principle and provides feasibility for a novel therapeutic strategy to inhibit atherosclerotic plaque burden by selective targeting of PAPP-A (show PAPPA ELISA Kits).
stimulation of PAPP-A (show PAPPA ELISA Kits) expression by intermittent PTH (show PTH ELISA Kits) treatment contributes to PTH (show PTH ELISA Kits) bone anabolism in mice
PAPP-A (show PAPPA ELISA Kits) affects fascicle structure, thereby affecting tendon phenotype.
This study demonstrated that cbp (show CREBBP ELISA Kits) increase in skeletal muscle in muscle atrophy.
PAG is constitutively phosphorylated in resting T cells and rapidly dephosphorylated once the TCR is engaged.
The protein encoded by this gene is a type III transmembrane adaptor protein that binds to the tyrosine kinase csk protein. It is thought to be involved in the regulation of T cell activation.
phosphoprotein associated with glycosphingolipid microdomains 1
, phosphoprotein associated with glycosphingolipid-enriched microdomains 1-like
, Csk-binding protein
, phosphoprotein associated with glycosphingolipid-enriched microdomains 1
, transmembrane adapter protein PAG
, transmembrane adaptor protein PAG
, transmembrane phosphoprotein Cbp
, Csk binding protein
, csk-binding protein
, phosphoprotein transmembrane adaptor 1
, phosphoprotein-associated with GEMs
, IGF-dependent IGFBP-4 protease
, insulin-like growth factor-dependent IGF-binding protein 4 protease