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our results identify the CD63 (show CD63 Proteins)-syntenin-1 (show SDCBP Proteins)-ALIX complex as a key regulatory component in post-endocytic HPV trafficking.
Alix acts in concert with endophilin A to promote clathrin-independent endocytosis of cholera toxin and to regulate cell migration.
Revealed the transition of diffuse ALIX protein signals into a multivesicular body-like pattern during adenoma-carcinoma sequence in colorectal neoplasms.
STAT3 (show STAT3 Proteins) bound to the 5' upstream sequence (-1971 to -1964), a putative promoter region, of WDR1 (show WDR1 Proteins) gene, and its activation induced WDR1 (show WDR1 Proteins) overexpression in breast cancer cells.
MRTF-A-miR (show MLXIP Proteins)-206-WDR1 (show WDR1 Proteins) form feedback loop to regulate breast cancer cell migration.
Alix plays an important role in the proliferation of glioma cells and overexpression in gliomas predicts poor survival.
homozygous missense L153F/L293F mutation in the actin regulatory gene WDR1 (show WDR1 Proteins) causes a new autoinflammatory disease in humans, with periodic fevers, immunodeficiency, and intermittent thrombocytopenia (PFIT).
These data suggest that WDR1 (show WDR1 Proteins) plays an important role in suppressing platelet activity, where it alters the actin cytoskeleton dynamics, and downregulation of WDR1 (show WDR1 Proteins) may contribute to the platelet-mediated pathogenesis of cardiovascular disease.
Mutations in WDR1 (show WDR1 Proteins) affect neutrophil morphology, motility, and function, causing a novel primary immunodeficiency
ALIX regulates P2Y1 (show P2RY1 Proteins) degradation.
By interacting with F-actin, the Par (show AFG3L2 Proteins) complex and ZO-1 (show TJP1 Proteins), Alix ensures the formation and maintenance of the apically restricted actomyosin-tight junction complex.
farnesylation of K-Ras (show HRAS Proteins) was required for its packaging within extracellular nanovesicles, yet expressing a K-Ras (show HRAS Proteins) farnesylation mutant did not decrease the number of nanovesicles or the amount of Alix protein released per cell.
ATG12 (show ATG12 Proteins)-ATG3 (show ATG3 Proteins) interacts with Alix to promote basal autophagic flux and late endosome function.
We have provided evidence that a promigratory function of galectin-3 (show LGALS3 Proteins) may be mediated through interaction with its binding partner Alix.
Identify key role for syndecan (show SDC1 Proteins)-syntenin (show SDCBP Proteins)-ALIX in membrane transport and signalling processes.
the Ozz-E3 ligase regulates Alix at sites where the actin cytoskeleton undergoes remodeling.
Alix is a crucial mediator of Ca(2 (show CA2 Proteins)+) induced caspase 9 (show CASP9 Proteins) activation.
Biochemical characterization of two analogues of the apoptosis-linked gene 2 protein (show PDCD6 Proteins) in Dictyostelium discoideum and interaction with murine Alix.
overexpression of Alix-CT leads to cytoplasmic vacuolization into tubulo-vesicular structures
We conclude that ALIX and ESCRT-III coordinately control abscission in Drosophila fGSCs and that their complex formation is required for accurate abscission timing in GSCs in vivo.
These findings establish that Xp95/Alix is phosphorylated within the proline-rich domain during M-phase induction, and indicate that the phosphorylation may both positively and negatively modulate their interaction with partner proteins.
This gene encodes a protein containing 9 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, mostly including a trp-asp at the C-terminal end. WD domains are involved in protein-protein interactions. The encoded protein may help induce the disassembly of actin filaments. Two transcript variants encoding different isoforms have been found for this gene.
ALG-2 interacting protein 1
, ALG-2-interacting protein X
, PDCD6-interacting protein
, apoptosis-linked gene 2-interacting protein X
, dopamine receptor interacting protein 4
, programmed cell death 6-interacting protein
, WD repeat-containing protein 1
, actin-interacting protein 1
, ALG-2-interacting protein 1
, Alg2-interacting protein 1
, Alg2-interacting protein X
, E2f1-inducible protein
, ALG-2 interacting protein X
, programmed cell death 6 interacting protein
, Programmed cell death 6 interacting protein
, putative signal tranduction protein Xp95
, signal transduction protein Xp95