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Human SERPINE1 Protein expressed in Escherichia coli (E. coli) - ABIN2544553
Damare, Brandal, Fortenberry: Inhibition of PAI-1 antiproteolytic activity against tPA by RNA aptamers. in Nucleic acid therapeutics 2014
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Human SERPINE1 Protein expressed in Escherichia coli (E. coli) - ABIN2544220
Cochran, Croucher, Lobov, Saunders, Ranson: Dependence on endocytic receptor binding via a minimal binding motif underlies the differential prognostic profiles of SerpinE1 and SerpinB2 in cancer. in The Journal of biological chemistry 2011
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Human SERPINE1 Protein expressed in Escherichia coli (E. coli) - ABIN2544358
Arndt, Young, Worthen: Regulation of lipopolysaccharide-induced lung inflammation by plasminogen activator Inhibitor-1 through a JNK-mediated pathway. in Journal of immunology (Baltimore, Md. : 1950) 2005
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Mouse (Murine) SERPINE1 Protein expressed in Escherichia coli (E. coli) - ABIN2544490
Reichel, Uhl, Lerchenberger, Puhr-Westerheide, Rehberg, Liebl, Khandoga, Schmalix, Zahler, Deindl, Lorenzl, Declerck, Kanse, Krombach: Urokinase-type plasminogen activator promotes paracellular transmigration of neutrophils via mac-1, but independently of urokinase-type plasminogen activator receptor. in Circulation 2011
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Mouse (Murine) SERPINE1 Protein expressed in Escherichia coli (E. coli) - ABIN2544492
Vayalil, Olman, Murphy-Ullrich, Postlethwait, Liu: Glutathione restores collagen degradation in TGF-beta-treated fibroblasts by blocking plasminogen activator inhibitor-1 expression and activating plasminogen. in American journal of physiology. Lung cellular and molecular physiology 2005
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Human SERPINE1 Protein expressed in Escherichia coli (E. coli) - ABIN2544556
Minor, Schar, Blouse, Shore, Lawrence, Schuck, Peterson: A mechanism for assembly of complexes of vitronectin and plasminogen activator inhibitor-1 from sedimentation velocity analysis. in The Journal of biological chemistry 2005
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Human SERPINE1 Protein expressed in Insect Cells - ABIN2544291
Gorlatova, Cale, Elokdah, Li, Fan, Warnock, Crandall, Lawrence: Mechanism of inactivation of plasminogen activator inhibitor-1 by a small molecule inhibitor. in The Journal of biological chemistry 2007
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Human SERPINE1 Protein expressed in Escherichia coli (E. coli) - ABIN2544360
Wan, Gao, Zhou, Zhang, Hao, Lian, Li, Chen, Liu: SIRT1-mediated epigenetic downregulation of plasminogen activator inhibitor-1 prevents vascular endothelial replicative senescence. in Aging cell 2014
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Rat (Rattus) SERPINE1 Protein expressed in Escherichia coli (E. coli) - ABIN2544624
Guizzetti, Moore, Giordano, Costa: Modulation of neuritogenesis by astrocyte muscarinic receptors. in The Journal of biological chemistry 2008
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Human SERPINE1 Protein expressed in Human Cells - ABIN2002529
Forsyth, Horvath, Coughlin: A review and comparison of the murine alpha1-antitrypsin and alpha1-antichymotrypsin multigene clusters with the human clade A serpins. in Genomics 2003
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Elevated donor plasminogen activator inhibitor-1 levels are associated with the risk of primary graft dysfunction.
In this study, using the antioxidant N-acetylcysteine (NAC), the authors show that hypoxia-induced reactive oxygen species in MDA-MB-468 breast cancer cells, selectively regulate hypoxia-induced increases in N-cadherin and SERPINE1, two proteins involved in cell adhesion. Treatment of cells with NAC also attenuated hypoxia-mediated activation of EGFR, but did not have any effect on hypoxia-mediated induction of HIF1alpha.
our results indicate that PAI-1 prevents the PA-driven proteolysis of FGF23 and PAI-1 inhibition provides a novel therapeutic approach to prevent the pathologic consequences of increased FGF23.
Studied association of plasma levels of serpin family E member 1 (PAI-1) and preeclampsia. Found first trimester PAI-1 levels were significantly higher in the women who later developed preeclampsia compared to those women who had a normal pregnancy.
These results suggest that miR-17~92 regulates the PASMC contractile phenotype and proliferation coordinately and synergistically by direct and indirect targeting of PAI-1.
PAI-1, but not PZ, seems to be an acute phase protein in HL.
PAI-1 is associated with a number of parameters that may reflect biological aging, including leukocyte telomere length, metabolism, and life span.
High PAI-1 expression is associated with Venoocclusive disease.
Study indicates that uPA and PAI-1 tumor tissue levels and 4G/5G variants of PAI-1 gene might be of prognostic significance in early node-negative luminal HER2-negative breast cancer patients treated with adjuvant endocrine therapy.
The abnormal levels of PAI-1, D-dimer and tPA imply that they contribute to the exaggerated hypercoagulabilty state in pre-eclampsia thus, measuring their levels can help in the management of the condition.
Stress granules-mediated inhibition of senescence is associated with the recruitment of the plasminogen activator inhibitor-1, a known promoter of senescence, to these entities.
the tPA A146Y variant not only increases the catalytic efficiency of the enzyme, but also enhances resistance to PAI-1 inhibition
The present study suggests that both the t-PA -7351C > T and the PAI-1 4G/5G gene variants are unlikely major risk factors for central serous chorioretinopathy.
Thrombin elicits increased amounts of PAI-1 release from liver endothelium compared with lung, with a small presynthesized stored contribution and a later, larger increase in PAI-1 release via de novo synthesis.
found at the polymorphic site in PAI-1 gene between temporal lobe epilepsy patients and controls
serum PAI-1 levels were positively associated with colonic polyp size and high-grade dysplasia, which was modulated by the PAI-1-rs-17998894G/4G genotype.
The simulations reveal notable conformational flexibility of helices D, E and F and major fluctuations are observed in the W86-loop which occasionally leads to progressive detachment of beta-strand 2 A from beta-strand 3 A.
Hypoadiponectinemia and rising PAI-1 over time are early features of the cardiometabolic biomarker profile of women with recent gestational dysglycemia.
Positive PAI-1 membrane expression was significantly associated with local disease relapse of oral squamous cell carcinoma.
The 4G/4G, 4G/5G, and 5G/5G genotype frequencies were 40.0%, 46.4%, and 13.6% in the control group versus 31.4%, 52.0% and 16.6% in the IS group, respectively. The PAI-1 genotype dominant allele model was a risk factor for IS in patients with T2DM of Jinan, China.
The serpin PN1 is a feedback regulator of FGF signaling in germ layer and primary axis formation.
a highly dynamic endocardium in the regenerating zebrafish heart, with two key endocardial players, Serpine1 and Notch signalling, regulating crucial regenerative processes, is reported.
SERPINe1-derived 14-mer peptide and low molecular weight drugs targeting SERPINe1 (i.e. tannic acid, EGCG, tiplaxtinin) inhibited in vitro infections not only of viral haemorrhagic septicemia virus, but also of other fish rhabdoviruses.
X-ray crystal structure analysis of glycosylated fish PAI-1 confirmed the presence of an N-linked glycan in the gate region and a lack of glycan-induced structural changes.
Mast cell-derived PAI-1 contributes to airway inflammation, goblet cell hyperplasia, collagen deposition, and airway hyperresponsiveness
PAI-1 functions as an inflammatory mediator that is rapidly deposited on the microvascular endothelium on ischemia-reperfusion injury and subsequently induces conformational changes in beta2 integrins of intravascularly rolling neutrophils.
endogenous RNA (Serpine1) controls the degradation of two miRNAs (miR-30b-5p and miR-30c-5p) in mouse fibroblasts
Results indicate that circadian locomotor output cycles kaput protein (CLOCK) overexpression triggers the formation of atherosclerotic plaques by directly upregulating plasminogen activator inhibitor 1 (PAI-1) expression.
In conclusion, we demonstrated that type 1 diabetes decreases accumulation and phagocytosis of macrophages at the damaged site during early bone repair after femoral bone injury through PAI-1 in female mice.
upregulation of PAI-1 may be a critical mechanism underlying insufficient neurotrophic support and increased neurodegeneration associated with AD. Thus, targeting BDNF maturation through pharmacological inhibition of PAI-1 might become a potential treatment for AD.
Findings indicate that plasminogen activator inhibitor-1 protects mice from hypertension-induced cardiac fibrosis by inhibiting the generation of active plasmin.
The effects of genetic alterations in PAI-1 expression, pharmacologic PAI-1 inhibition and recombinant PAI-1 on smooth muscle cell vitronectin (VN) expression were studied, and vascular VN expression in wild-type and PAI-1-deficient mice was assessed.
PAI-1 deficiency accelerates subchondral osteopenia after induction of osteoarthritis.
PAI-1 induces alveolar type II cell senescence through activating p53-p21-Rb pathway in fibrotic lung disease.
paracrine PAI-1 is involved in glucocorticoid-induced muscle wasting through the enhancement of muscle degradation in mice.
day-night feeding cycle is not a critical Zeitgeber for circadian rhythm of circulating PAI-1
PAI-1 is an in vivo target of the Pla protease in the lungs, and PAI-1 is a key regulator of the pulmonary innate immune response
the role of the antifibrinolytic protein plasminogen activator inhibitor-1 (PAI-1) in alcohol enhancement of experimental endotoxin-induced acute lung injury, is reported.
PAI-1 inhibitor PAI-039 prevents smooth muscle cell migration and neointimal hyperplasia.
Tongqiaohuoxue decoction exerted an anti-thrombotic effect through the regulation of PAI-1 and fibrinolysis.
PAI-1 plays a role in maintaining gastric mucosal organization in hypergastrinemia.
Olmesartan did not significantly affect PAI1 levels in this mouse model
BRD2 is involved in the modulation of neuroinflammatory responses through PAI-1 and via the regulation of epigenetic reader BET protein
Neutralization of the antifibrinolytic function of PAI-1 resolves skin fibrosis by limiting the extent of initial vascular injury and connective tissue inflammation.
In one pig population and in female pigs, SERPINE1 (serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1) was significantly associated with muscling, growth and fat accretion and in male animals with meat quality.
Data show that urokinase-type plasminogen activator (uPA) is only expressed in the cumulus cells of immature and in vitro matured cumulus-oocyte complexes (COCs), while uPA receptor (uPAR) and plasminogen activator inhibitor-1 (PAI-1) are expressed in both the cumulus cells and the immature and in vitro matured oocytes.
Data suggest PAI1 plays key role in modulating chromaffin cell neurosecretory function. Evidence is presented that in chromaffin cells, PAI1 is targeted to storage vesicles and co-released with catecholamine upon secretagogue/stress stimulation.
the PI3K/Akt pathway acts as a negative regulator of PAI-1 expression in vascular endothelial cells, in part, through the downregulation of MAPK pathways
high glucose-induced plasminogen activator inhibitor-1 (PAI-1) expression in endothelial cells is mediated by NF-kappaB activation through the Rho/Rho-kinase pathway
FoxO1 inhibits PAI-1 expression through the inhibition of TGF-beta/Smad-mediated signaling pathways.
This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
endothelial plasminogen activator inhibitor
, plasminogen activator inhibitor 1
, serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
, serpin E1
, serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
, PAI 1
, serine (or cysteine) proteinase inhibitor, clade E, member 1
, putative plasminogen activator inhibitor-1
, chemokine CCL-C25s
, plasminogen activator inhibitor 1-like
, Plasminogen activator inhibitor-1 precursor (PAI-1) (Endothelial plasminogen activator inhibitor) (PAI)
, nexin, plasminogen activator inhibitor type 1
, plasminogen activator inhibitor, type I
, serine (or cysteine) peptidase inhibitor, clade E, member 1
, serine (or cysteine) proteinase inhibitor, member 1
, plasminogen activator inhibitor I
, plasminogen activator inhibitor type 1
, plasminogen activator inhibitor, type 1
, plasminogen activator inhibitor-1