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Tbx2 mediates BMP signal to down-regulate FGF signaling pathway by repressing Flrt3 expression for anterior tissue formation.
Results suggest that the negative regulatory loops between BMP/Tbx2 and Gremlin or Hey1 are responsible for defining the territory of the pronephric nephron.
Bone morphogenetic protein signaling regulates hepatoblast-like cell differentiation into hepatocytes through tbx2b.
tbx2a/b mitigate pronephros segmentation downstream of retinoic acid.
propose here a rather unique role of Med10 in orchestrating cardiac valve formation by mediating Foxn4 dependent tbx2b transcription, expression of Has2 and subsequently proper development of the cardiac jelly
This work establishes a novel link between tbx2b and gdf6a in determining photoreceptor fates.
Genetic disruption of the transcription factor Tbx2b eliminates most of the cone subtype maximally sensitive to ultraviolet wavelengths and also perturbs the long-range organization of the cone lattice.
CNBP up-regulates tbx2b and smarca5, and down-regulates wnt5b gene expression.
Wnt/beta-catenin signaling is both sufficient and required for the induction of BMP4 and Tbx2b expression in the AVC
In zebrafish, two tbx2 genes are functionally redundant for regulating chamber development, while each gene is required independently for development of the atrioventricular canal.
results uncover an evolutionarily conserved role of Tbx2/3 transcription factors during remodeling of the heart myocardium and highlight the importance of controlling cell proliferation as a driving force of morphogenesis
cellular mechanisms regulating neuronal differentiation within the retina are asymmetric about the dorsal/ventral axis, and Tbx2b mediates this process within the dorsal retina
Data show that tbx2b transcripts are present during mid-gastrula before its expression is detected by whole-mount in situ hybridization.
tbx2b functions to specify the correct number of parapineal cells and to regulate their asymmetric migration.
Flh and Tbx2b regulate separate programs of pineal and parapineal development
tbx2b in photoreceptor cell precursors promote the UV cone fate by repressing the rod differentiation pathway
TBX-2 functions as an UNC-37 dependent transcriptional repressor
Reduction of SUMOylation enhances the effect of a tbx-2 hypomorphic mutant on embryonic viability and pharyngeal muscle development, and that repression of a downstream target of TBX-2 depends on SUMOylation.
These results identify NF-Y as an important regulator of tbx-2 function in vivo.
Ce-TBX-2, the TBX2/TBX3 transcriptional factor homologue of the nematode Caenorhabditis elegans, is involved in olfactory adaptation
TBX-2 and SUMO-conjugating enzymes are necessary for ABa-derived pharyngeal muscle, and we hypothesize that TBX-2 function requires sumoylation.
The analysis suggests that a positive feedback loop between tbx-2 and pha-4 is required for blastomere-derived precursors to commit to pharyngeal muscle fate.
In screens for mutants with abnormal HSN motor neuron development, we identified the T-box protein TBX-2 as being important for both HSN and PHB sensory neuron differentiation.
The minor C allele of rs4455026 in TBX2 promoter region was related with lower congenital heart disease susceptibility in the Han Chinese population via repressing its transcriptional activity.
transcription factor TBX2 is able to restrain ADAM10 gene expression and that this mechanism might play a role in regulating cellular processes in health, development and disease.
We report four individuals with an overlapping spectrum of craniofacial dysmorphisms, cardiac anomalies, skeletal malformations, immune deficiency, endocrine abnormalities and developmental impairments, reminiscent of DiGeorge syndrome, who are heterozygotes for TBX2 variants.
Our results indicate that the R608W and R616Q variants of TBX2 as well as the A192T and A562V variants of TBX3 contribute to Conotruncal heart defects (CTDs)etiology; this was the first association of variants of TBX2 and TBX3 to CTDs based on a large population.
TBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets.
The results indicated that the expression rates of TBX2 were significantly increased in the prostate cancerous tissues, compared with the healthy tumor adjacent tissue, and TBX2 increased staining was associated with the clinical stage and pathological grade.
TBX2 is a central component of the PTEN/PI3K/AKT signaling pathway deregulation in RMS cells and that targeting TBX2 in RMS tumors may offer a novel therapeutic approach for RMS
this new molecular-grade based on the combination of TBX2 and TBX3 methylation is an excellent marker for predicting progression to muscle-invasive bladder cancer in patients with primary pTaG1/2 bladder cancer.
Our results suggest a conserved role of Tbx2-related proteins in cell invasion and metastasis-related processes
Data show that the down-regulation of T-box transcription factor TBX2 by transforming growth factor beta I (TGF-beta1) is mediated by T-box transcription factor TBX3.
The data suggested that the DNA sequence variants within the TBX2 gene promoter was implicated in the indirect inguinal hernia development as a rare cause.
High TBX2 expression is associated with breast cancer.
High TBX2 expression is associated with non-small cell lung cancer.
TBX2 was a significantly prognostic factor for decreased survival.
deregulated TBX2 serves as an oncogene in rhabdomyosarcoma
Knocking down TBX2 sensitises the cells to cisplatin by disrupting the ATM-CHK2-p53 signalling pathway.
DNA sequence variants within TBX2 gene promoter may contribute to ventricular septal defects ethiology
The identification of TBX2 as a target for PAX3 provides a key insight into how PAX3 may contribute to melanoma evolution.
Coimmunoprecipitations and immunofluorescence analyses confirmed the L2-TBX2 interaction and revealed that human papillomavirus 16 L2 also interacts with human TBX3, another member of the T-box family.
an unanticipated link between TBX2 deregulation in cancer and the acquisition of EMT and invasive features of epithelial tumor cells
TBX2 and TBX3 transcription factors have novel and required roles in regulating patterning and differentiation in the murine ureter.
TBX2 is expressed in RPE cells both in vivo and in vitro. Specific knockdown of TBX2 in the human RPE cell line ARPE-19 leads to an accumulation of cells at G1.
Tbx18 does not function redundantly with Tbx2 or Tbx20 in epicardial development.
Tbx2 and Tbx3 function downstream of Shh to maintain pro-proliferative mesenchymal Wnt signaling.
Standard chromatin immunoprecipitation and reporter assays suggest that TBX2 represses Oca2 at least in part directly. Hence, the results suggest that TBX2 may act as a nexus linking cell proliferation and melanogenesis
Msx1 and Tbx2 antagonistically regulate Bmp4 expression during the bud-to-cap stage transition in tooth development.
formation of the neurohypophysis requires Tbx3 and Tbx2 to sequester the SRY box-containing transcription factor Sox2 away from a Shh forebrain enhancer (SBE2)
We show that Tbx2 directly represses Grem1 in distal regions of the posterior limb mesenchyme allowing Bone morphogenetic protein (Bmp) signaling to abrogate Fgf4/9/17 expression in the overlying epithelium.
Tbx2-mediated regulation of Cdkn1a and Cdkn1b represents a crucial node in the network integrating patterning information and cell cycle regulation that underlies growth, differentiation, and branching morphogenesis of this organ.
an unanticipated link between TBX2 deregulation in cancer and the acquisition of EMT and invasive features of epithelial tumor cells.
This study lays the foundation for investigation of functional requirements for Tbx2 subfamily genes in development of the mammalian reproductive system.
Tbx2 and Tbx3 trigger development of the endocardial cushions through a regulatory feed-forward loop with Bmp2, thus providing a mechanism for the co-localization and coordination of these important processes in heart development.
Tbx2 and Tbx3 are both expressed in the pancreatic mesenchyme throughout development
The Tbx2-Tgfbeta2 cascade is one of the key pathways involved in inducing the transposition of the great arteries phenotype.
Data show that myocardium-specific inactivation of T-box 2 (Tbx2) leads to the formation of fast-conducting accessory pathways, malformation of the annulus fibrosus, and ventricular preexcitation in mice.
Study identify that the homeobox gene Nkx2-5 is required for early ventral restriction of Slit3 and that the T-box transcription factor Tbx2 mediates repression of Slit3 in nonchamber myocardium.
This review presents a state of the art overview of the role and regulation of Tbx2 in early embryonic development and in cancer[review]
Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal thus suppressing myocardial chamber formation
T-box transcription factor Tbx2 represses differentiation and formation of the cardiac chambers.
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product is the human homolog of mouse Tbx2, and shares strong sequence similarity with Drosophila omb protein. Expression studies indicate that this gene may have a potential role in tumorigenesis as an immortalizing agent. Transcript heterogeneity due to alternative polyadenylation has been noted for this gene.
T-Box protein 2
, T-box transcription factor TBX2-A
, T-box protein 2-A
, T-box transcription factor Tbx2
, T-box gene C
, T-box protein 2b
, T-box transcription factor TBX2b
, T-box 2
, T-box transcription factor 2
, T-box transcription factor TBX2-like
, T-box transcription factor TBX2
, T-box 2 protein
, T-box protein 2
, T-box 2 transcription factor