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Tbx2 mediates BMP signal to down-regulate FGF signaling pathway by repressing Flrt3 (show FLRT3 Proteins) expression for anterior tissue formation.
Results suggest that the negative regulatory loops between BMP/Tbx2 and Gremlin (show GREM1 Proteins) or Hey1 (show HEY1 Proteins) are responsible for defining the territory of the pronephric nephron.
Bone morphogenetic protein signaling regulates hepatoblast-like cell differentiation into hepatocytes through tbx2b.
propose here a rather unique role of Med10 (show MED10 Proteins) in orchestrating cardiac valve formation by mediating Foxn4 (show FOXN4 Proteins) dependent tbx2b transcription, expression of Has2 (show HAS2 Proteins) and subsequently proper development of the cardiac jelly
This work establishes a novel link between tbx2b and gdf6a in determining photoreceptor fates.
CNBP (show CNBP Proteins) up-regulates tbx2b and smarca5 (show SMARCA5 Proteins), and down-regulates wnt5b (show WNT5B Proteins) gene expression.
Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling is both sufficient and required for the induction of BMP4 (show BMP4 Proteins) and Tbx2b expression in the AVC
In zebrafish, two tbx2 genes are functionally redundant for regulating chamber development, while each gene is required independently for development of the atrioventricular canal.
results uncover an evolutionarily conserved role of Tbx2/3 transcription factors during remodeling of the heart myocardium and highlight the importance of controlling cell proliferation as a driving force of morphogenesis
Flh and Tbx2b regulate separate programs of pineal and parapineal development
TBX-2 functions as an UNC-37 dependent transcriptional repressor
Reduction of SUMOylation enhances the effect of a tbx-2 hypomorphic mutant on embryonic viability and pharyngeal muscle development, and that repression of a downstream target of TBX-2 depends on SUMOylation.
These results identify NF-Y as an important regulator of tbx-2 function in vivo.
Ce-TBX-2, the TBX2/TBX3 (show TBX3 Proteins) transcriptional factor homologue of the nematode Caenorhabditis elegans, is involved in olfactory adaptation
TBX-2 and SUMO-conjugating enzymes are necessary for ABa-derived pharyngeal muscle, and we hypothesize that TBX-2 function requires sumoylation.
The analysis suggests that a positive feedback loop between tbx-2 and pha-4 is required for blastomere-derived precursors to commit to pharyngeal muscle fate.
In screens for mutants with abnormal HSN (show FSCN1 Proteins) motor neuron development, we identified the T-box protein TBX-2 as being important for both HSN (show FSCN1 Proteins) and PHB (show PHB Proteins) sensory neuron differentiation.
The results indicated that the expression rates of TBX2 were significantly increased in the prostate cancerous tissues, compared with the healthy tumor adjacent tissue, and TBX2 increased staining was associated with the clinical stage and pathological grade.
TBX2 is a central component of the PTEN/PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) signaling pathway deregulation in RMS cells and that targeting TBX2 in RMS tumors may offer a novel therapeutic approach for RMS
this new molecular-grade based on the combination of TBX2 and TBX3 (show TBX3 Proteins) methylation is an excellent marker for predicting progression to muscle-invasive bladder cancer in patients with primary pTaG1/2 bladder cancer.
Our results suggest a conserved role of Tbx2-related proteins in cell invasion and metastasis-related processes
Data show that the down-regulation of T-box transcription factor TBX2 by transforming growth factor beta I (TGF-beta1 (show TGFB1 Proteins)) is mediated by T-box transcription factor TBX3 (show TBX3 Proteins).
The data suggested that the DNA sequence variants within the TBX2 gene promoter was implicated in the indirect inguinal hernia development as a rare cause.
High TBX2 expression is associated with breast cancer.
High TBX2 expression is associated with non-small cell lung cancer.
TBX2 was a significantly prognostic factor for decreased survival.
deregulated TBX2 serves as an oncogene (show RAB1A Proteins) in rhabdomyosarcoma
TBX2 is expressed in RPE (show RPE Proteins) cells both in vivo and in vitro. Specific knockdown of TBX2 in the human RPE (show RPE Proteins) cell line ARPE-19 leads to an accumulation of cells at G1.
Tbx18 (show TBX18 Proteins) does not function redundantly with Tbx2 or Tbx20 (show TBX20 Proteins) in epicardial development.
Tbx2 and Tbx3 (show TBX3 Proteins) function downstream of Shh (show SHH Proteins) to maintain pro-proliferative mesenchymal Wnt (show WNT2 Proteins) signaling.
Standard chromatin immunoprecipitation and reporter assays suggest that TBX2 represses Oca2 at least in part directly. Hence, the results suggest that TBX2 may act as a nexus linking cell proliferation and melanogenesis
Msx1 (show MSX1 Proteins) and Tbx2 antagonistically regulate Bmp4 (show BMP4 Proteins) expression during the bud-to-cap stage transition in tooth development.
formation of the neurohypophysis requires Tbx3 (show TBX3 Proteins) and Tbx2 to sequester the SRY box-containing transcription factor Sox2 (show SOX2 Proteins) away from a Shh (show SHH Proteins) forebrain enhancer (SBE2)
We show that Tbx2 directly represses Grem1 in distal regions of the posterior limb mesenchyme allowing Bone morphogenetic protein (Bmp) signaling to abrogate Fgf4/9/17 expression in the overlying epithelium.
The identification of TBX2 as a target for PAX3 (show PAX3 Proteins) provides a key insight into how PAX3 (show PAX3 Proteins) may contribute to melanoma evolution.
Tbx2-mediated regulation of Cdkn1a (show CDKN1A Proteins) and Cdkn1b (show CDKN1B Proteins) represents a crucial node in the network integrating patterning information and cell cycle regulation that underlies growth, differentiation, and branching morphogenesis of this organ.
an unanticipated link between TBX2 deregulation in cancer and the acquisition of EMT (show ITK Proteins) and invasive features of epithelial tumor cells.
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product is the human homolog of mouse Tbx2, and shares strong sequence similarity with Drosophila omb protein. Expression studies indicate that this gene may have a potential role in tumorigenesis as an immortalizing agent. Transcript heterogeneity due to alternative polyadenylation has been noted for this gene.
T-Box protein 2
, T-box transcription factor TBX2-A
, T-box protein 2-A
, T-box transcription factor Tbx2
, T-box gene C
, T-box protein 2b
, T-box transcription factor TBX2b
, T-box 2
, T-box transcription factor 2
, T-box transcription factor TBX2-like
, T-box transcription factor TBX2
, T-box 2 protein
, T-box protein 2
, T-box 2 transcription factor