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High TRIM29 expression is associated with invasion in hepatocellular carcinoma.
Results show that the depletion of tripartite motif-containing 29 protein (TRIM29) promoted liver cancer cell proliferation, clone formation, migration and invasion in vitro probably through the Wnt/beta-catenin signaling pathway.
decreased expression of miR-122 and increased expression of TRIM29 was significantly associated with poor prognosis in patients with NPC.
Ectopic expression of TRIM29 potentially contributes to metastasis and poor prognosis in patients with osteosarcoma.
Knockdown of tripartite motif-containing 29 protein (TRIM29) enhanced the production of type I interferon in human and mouse dendritic cells by up to fourfold in response to intracellular herpes simplex virus.
the current study demonstrated that TRIM29 upregulates cyclin and Bcl family proteins level to facilitate malignant cell growth and inhibit drug-induced apoptosis in bladder cancer, possibly through PKC-NF-kappaB signaling pathways.
High TRIM29 expression is associated with metastasis of nasopharyngeal carcinoma.
Data show that TRIM29 promotes tumor progression by activating Wnt/beta-Catenin signaling.
This study establishes TRIM29 as a hypoxia-induced tumor suppressor gene and provides a novel molecular mechanism for ATM-dependent breast cancer suppression.
Upregulation of TRIM29 is associated with thyroid cancer.
miR-761 acts as an oncogene in triple-negative breast cancer. This mode of action can, at least partially, be ascribed to the down-regulation of its target TRIM29.
Silencing of TRIM29 significantly inhibited the migration and invasion ability of CRC cells.
Findings established a role for ATDC/TRIM29 as a robust pathogenic driver of bladder cancer development, identified downstream effector pathways, and implicated ATDC as a candidate biomarker and therapeutic target.
define a novel function for ATDC in the RNF8-mediated DNA damage response and implicate RNF8 binding as a key determinant of the radioprotective function of ATDC
Results suggest that TRIM29 functions as an oncogene in gastric cancer and is regulated by miR-185.
TRIM29 functions as a scaffold protein to assemble DNA repair proteins into chromatin followed by efficient activation of DNA damage response.
These findings suggest that TRIM29 regulates the p63-mediated pathway and the behavior of cervical cancer cells.
Down-regulation of ATDC inhibits the growth and proliferation of esophageal carcinoma cells.
TRIM29 may be useful marker for distinguishing prostate cancers from benign tissues
TWIST1 inhibited TRIM29 promoter activity.
TRIM29 regulates negatively the host innate immune response to RNA virus, which could be employed by RNA viruses for viral pathogenesis.
this study shows that deletion of TRIM29 enhanced macrophage production of type I interferons and protected mice from infection with influenza virus, while challenge of Trim29-/- mice with Haemophilus influenzae resulted in lethal lung inflammation due to massive production of proinflammatory cytokines by macrophages
ATDC up-regulates CD44 in mouse and human PanIN lesions via activation of beta-catenin signaling, leading to the induction of an epithelial-to-mesenchymal transition (EMT) phenotype characterized by expression of Zeb1 and Snail1.
Histone deacetylase 9 (HDAC9) regulates the functions of the ATDC (TRIM29) protein
ATDC increases cell proliferation via inhibition of p53 nuclear activities.
The protein encoded by this gene belongs to the TRIM protein family. It has multiple zinc finger motifs and a leucine zipper motif. It has been proposed to form homo- or heterodimers which are involved in nucleic acid binding. Thus, it may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation. It may also function in the suppression of radiosensitivity since it is associated with ataxia telangiectasia phenotype.
ataxia telangiectasia group D-associated protein
, ataxia-telangiectasia group D-associated protein
, tripartite motif protein TRIM29
, tripartite motif-containing 29
, tripartite motif-containing protein 29
, tripartite motif protein 29
, tripartite motif-containing protein 29-like