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Knockdown of tripartite motif-containing 29 protein (TRIM29) enhanced the production of type I interferon (show IFNA Proteins) in human and mouse dendritic cells by up to fourfold in response to intracellular herpes simplex virus.
the current study demonstrated that TRIM29 upregulates cyclin (show PCNA Proteins) and Bcl family proteins level to facilitate malignant cell growth and inhibit drug-induced apoptosis in bladder cancer, possibly through PKC (show PRRT2 Proteins)-NF-kappaB (show NFKB1 Proteins) signaling pathways.
High TRIM29 expression is associated with metastasis of nasopharyngeal carcinoma.
Data show that TRIM29 promotes tumor progression by activating Wnt (show WNT2 Proteins)/beta-Catenin (show CTNNB1 Proteins) signaling.
This study establishes TRIM29 as a hypoxia-induced tumor suppressor gene and provides a novel molecular mechanism for ATM (show ATM Proteins)-dependent breast cancer suppression.
Upregulation of TRIM29 is associated with thyroid cancer.
miR (show MLXIP Proteins)-761 acts as an oncogene (show RAB1A Proteins) in triple-negative breast cancer. This mode of action can, at least partially, be ascribed to the down-regulation of its target TRIM29.
Silencing of TRIM29 significantly inhibited the migration and invasion ability of CRC (show CALR Proteins) cells.
Findings established a role for ATDC/TRIM29 as a robust pathogenic driver of bladder cancer development, identified downstream effector pathways, and implicated ATDC as a candidate biomarker and therapeutic target.
define a novel function for ATDC in the RNF8 (show RNF8 Proteins)-mediated DNA damage response and implicate RNF8 (show RNF8 Proteins) binding as a key determinant of the radioprotective function of ATDC
this study shows that deletion of TRIM29 enhanced macrophage production of type I interferons and protected mice from infection with influenza virus, while challenge of Trim29-/- mice with Haemophilus influenzae resulted in lethal lung inflammation due to massive production of proinflammatory cytokines by macrophages
ATDC up-regulates CD44 (show CD44 Proteins) in mouse and human PanIN lesions via activation of beta-catenin (show CTNNB1 Proteins) signaling, leading to the induction of an epithelial-to-mesenchymal transition (EMT (show ITK Proteins)) phenotype characterized by expression of Zeb1 and Snail1 (show SNAI1 Proteins).
Histone deacetylase 9 (HDAC9 (show HDAC9 Proteins)) regulates the functions of the ATDC (TRIM29) protein
ATDC increases cell proliferation via inhibition of p53 (show TP53 Proteins) nuclear activities.
The protein encoded by this gene belongs to the TRIM protein family. It has multiple zinc finger motifs and a leucine zipper motif. It has been proposed to form homo- or heterodimers which are involved in nucleic acid binding. Thus, it may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation. It may also function in the suppression of radiosensitivity since it is associated with ataxia telangiectasia phenotype.
ataxia telangiectasia group D-associated protein
, ataxia-telangiectasia group D-associated protein
, tripartite motif protein TRIM29
, tripartite motif-containing 29
, tripartite motif-containing protein 29
, tripartite motif protein 29
, tripartite motif-containing protein 29-like