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Human Monoclonal TWIST1 Primary Antibody for ICC, IF - ABIN2668516
Ezponda, Popovic, Shah, Martinez-Garcia, Zheng, Min, Will, Neri, Kelleher, Yu, Licht: The histone methyltransferase MMSET/WHSC1 activates TWIST1 to promote an epithelial-mesenchymal transition and invasive properties of prostate cancer. in Oncogene 2013
Show all 5 Pubmed References
Human Monoclonal TWIST1 Primary Antibody for IP, RNAi - ABIN563296
Saito, Murata-Kamiya, Hirayama, Ohba, Hatakeyama: Conversion of Helicobacter pylori CagA from senescence inducer to oncogenic driver through polarity-dependent regulation of p21. in The Journal of experimental medicine 2010
Show all 3 Pubmed References
Human Monoclonal TWIST1 Primary Antibody for ELISA, WB - ABIN1098133
Yu, Li, Lu, Tian, Ma, Wang, Xu: Down-regulation of TWIST decreases migration and invasion of laryngeal carcinoma Hep-2 cells by regulating the E-cadherin, N-cadherin expression. in Journal of cancer research and clinical oncology 2011
Show all 2 Pubmed References
Human Polyclonal TWIST1 Primary Antibody for IHC (p), IHC - ABIN189738
Jin, Ren, Macarak, Rosenbloom et al.: Pathobiological mechanisms of peritoneal adhesions: The mesenchymal transition of rat peritoneal mesothelial cells induced by TGF-β1 and IL-6 requires activation of Erk1/2 and Smad2 linker region ... in Matrix biology : journal of the International Society for Matrix Biology 2016
Human Monoclonal TWIST1 Primary Antibody for IP, ELISA - ABIN521172
Cosset, Hamdan, Jeanpierre, Voeltzel, Sagorny, Hayette, Mahon, Dumontet, Puisieux, Nicolini, Maguer-Satta: Deregulation of TWIST-1 in the CD34+ compartment represents a novel prognostic factor in chronic myeloid leukemia. in Blood 2011
Cow (Bovine) Polyclonal TWIST1 Primary Antibody for IHC, WB - ABIN2780347
Reinhold, Kapadia, Liao, Naski: The Wnt-inducible transcription factor Twist1 inhibits chondrogenesis. in The Journal of biological chemistry 2006
Show all 2 Pubmed References
Human Monoclonal TWIST1 Primary Antibody for ICC, FACS - ABIN1724845
Weiss, Abel, Mayberry, Basile, Berger, Aplin: TWIST1 is an ERK1/2 effector that promotes invasion and regulates MMP-1 expression in human melanoma cells. in Cancer research 2012
Human Polyclonal TWIST1 Primary Antibody for CyTOF, FACS - ABIN4898987
Satelli, Mitra, Brownlee, Xia, Bellister, Overman, Kopetz, Ellis, Meng, Li: Epithelial-mesenchymal transitioned circulating tumor cells capture for detecting tumor progression. in Clinical cancer research : an official journal of the American Association for Cancer Research 2015
Frame-shift mutation in TWIST1 is associated with type 2 scurs syndrome.
Interaction with Snail1/2, and Twist function more generally, is regulated by GSK-3-beta-mediated phosphorylation of conserved sites in the WR domain.
Data indicate a mechanism in breast cancer cells that tripartite motif-containing 28 (show TRIM28 Antibodies) protein (TRIM28 (show TRIM28 Antibodies)) enhances metastasis by stabilizing TWIST1, suggesting that targeting TRIM28 (show TRIM28 Antibodies) could be an efficacious strategy in breast cancer treatment.
Twist1 and Snail1 (show SNAI1 Antibodies) expression levels were associated with lymphovascular space invasion, lymph node metastasis and histological grade in cervical squamous cell carcinoma.
gene TWIST1 showed no significant difference in expression between groups
the inhibition of Twist1 transfected with siRNA could enhance the irinotecan sensitivity in LoVo/CPT (show CHPT1 Antibodies)-11R cells and downregulate the expression of vimentin (show VIM Antibodies) and CD44 (show CD44 Antibodies). Our data provide evidence that EMT (show ITK Antibodies) and CSC-like phenotype induced by Twist1 contribute to acquire resistance to irinotecan and enhanced migration and invasion in colon cancer
TWIST1, in part via GAS6 (show GAS6 Antibodies) and L1CAM (show L1CAM Antibodies), led to higher expression and activation of Akt (show AKT1 Antibodies) upon cisplatin treatment, and inhibition of Akt (show AKT1 Antibodies) activation sensitized cells to cisplatin.
High Twist-1 expression, aberrant E-cadherin (show CDH1 Antibodies) and high EZH2 (show EZH2 Antibodies) expression in primary prostate cancer are considered as adverse prognostic markers of an aggressive tumor with high metastatic potential.
ADAM12 (show ADAM12 Antibodies) is induced by Twist1 and plays a crucial role in tumor invasion and metastasis by regulating both invadopodia and focal adhesions
Taken together, these findings demonstrated that Twist was upregulated in high invasion and metastasis cell lines as well as invasive ductal carcinoma (IDC (show LMNA Antibodies)) tissues companioned with downregulated expression of E-cadherin (show CDH1 Antibodies) and ER, which provides important clues for the deeper study of breast cancer
The mechanism study revealed that ASLNC02525, as an RNA sponge, broke the negative regulation of twist1 by hsa (show CD24 Antibodies)-miRNA-489-3p, and once ASLNC02525 was silenced, the highly expressed hsa (show CD24 Antibodies)-miRNA489-3p regained its regulation on twist1 and inhibited the proliferation and invasion.
the results from the present study indicate that BaP (show PHB2 Antibodies) enhances the epithelial-mesenchymal transition-associated migration of lung adenocarcinoma A549 cells by upregulating Twist1.
This study evaluated the role of Twist1 in the expression of other epithelial-mesenchymal transition transcription factors in tumor cells, including tumor progression, intravasation, and metastasis.
The authors demonstrate that Twist1 serine (Ser (show SIGLEC1 Antibodies)) 42 phosphorylation is required for endothelial-to-mesenchymal transition through TGF-beta (show TGFB1 Antibodies)-Smad (show SMAD1 Antibodies) signaling in vitro and in the mouse lung gel implantation system.
Overall, hypoxia-induced activation of Twist/miR (show MLXIP Antibodies)-214/E-cadherin (show CDH1 Antibodies) axis is involved in the EMT (show ITK Antibodies) of TECs, and anti-miR (show MLXIP Antibodies)-214 may be an attractive strategy to ameliorate the progression of renal fibrosis.
molecular and cellular processes that regulate dural Cerebral vein development in mammals and describe venous malformations in humans with craniosynostosis and TWIST1 mutations that are recapitulated in mouse models, are reported.
Methyltransferase G9A (show EHMT2 Antibodies) Regulates Osteogenesis via Twist Gene Repression in mice.
this study shows that loss of Twist1 in collagen-producing cells leads to increased bleomycin-induced pulmonary fibrosis, which is mediated by increased expression of CXCL12 (show CXCL12 Antibodies)
RNF8 (show RNF8 Antibodies)-promoted Twist ubiquitination is required for Twist localization to the nucleus for subsequent epithelial-mesenchymal transition and cancer stem cells functions, thereby conferring chemoresistance.
These results indicate that Twist1 Ser42 phosphorylation contributes to the pathogenesis of bleomycin-induced pulmonary fibrosis through angiopoietin-Tie2 (show TEK Antibodies) signaling.
the mesenchymal properties of the cranial mesoderm are likely to be regulated by a network of TWIST1 targets that influences the extracellular matrix and cell-matrix interactions, and collectively they are required for the morphogenesis of the craniofacial structures.
TWIST1 expression promotes developmental angiogenesis by inducing endothelial cell proliferation and migration.
the ventral migration of Cranial neural crest cells (CNCCs) away from a source of Bmps in the dorsal ectoderm promotes ectomesenchyme development by relieving Id2a-dependent repression of Twist1 function.
twist1a and twist1b control skeletal development and dorsoventral patterning by regulating runx2b in zebrafish
These observations are consistent with a role for twist1 in craniofacial, vertebral, and early renal development.
Basic helix-loop-helix (bHLH) transcription factors have been implicated in cell lineage determination and differentiation. The protein encoded by this gene is a bHLH transcription factor and shares similarity with another bHLH transcription factor, Dermo1. The strongest expression of this mRNA is in placental tissue\; in adults, mesodermally derived tissues express this mRNA preferentially. Mutations in this gene have been found in patients with Saethre-Chotzen syndrome.
twist homolog 1
, twist transcription factor
, twist homolog 1 (acrocephalosyndactyly 3; Saethre-Chotzen syndrome)
, hypothetical protein
, twist-like protein
, twist-related protein 1
, twist-related protein
, B-HLH DNA binding protein
, TWIST homolog of drosophila
, class A basic helix-loop-helix protein 38
, charlie chaplin
, polydactyly EMS
, twist gene homolog 1
, twist 1
, twist homolog 1 (Drosophila)