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anti-Human XPC Antibodies:
anti-Mouse (Murine) XPC Antibodies:
anti-Rat (Rattus) XPC Antibodies:
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Human Monoclonal XPC Primary Antibody for ICC, IF - ABIN151924
Aboussekhra, Biggerstaff, Shivji, Vilpo, Moncollin, Podust, Protić, Hübscher, Egly, Wood: Mammalian DNA nucleotide excision repair reconstituted with purified protein components. in Cell 1995
Show all 18 Pubmed References
Human Polyclonal XPC Primary Antibody for IP, WB - ABIN188792
Rageul, Frëmin, Ezan, Baffet, Langouët: The knock-down of ERCC1 but not of XPF causes multinucleation. in DNA repair 2011
Show all 2 Pubmed References
Human Polyclonal XPC Primary Antibody for IF (p), IHC (p) - ABIN719171
Biswas, Mitchell, Johnson: E2F1 responds to ultraviolet radiation by directly stimulating DNA repair and suppressing carcinogenesis. in Cancer research 2014
Human Polyclonal XPC Primary Antibody for WB - ABIN1882000
Stern, Lin, Figueroa, Kelsey, Kiltie, Yuan, Matullo, Fletcher, Benhamou, Taylor, Placidi, Zhang, Steineck, Rothman, Kogevinas, Silverman, Malats, Chanock, Wu, Karagas: Polymorphisms in DNA repair genes, smoking, and bladder cancer risk: findings from the international consortium of bladder cancer. in Cancer research 2009
Several mutations in the two parts of the central "crest" of the arrestin (show SAG Antibodies) molecule, middle-loop and C-loop, enhanced or reduced arrestin-3 (show ARRB2 Antibodies) interactions with several GPCRs in receptor subtype and functional state-specific manner.
these studies found that carriers of the T allele of ERCC1 (show ERCC1 Antibodies) rs11615, XPC rs2228000 and rs50872, particularly in postmenopausal females, have an increased risk of breast cancer
Data suggest that a common TFIIH subunit (show GTF2H4 Antibodies) p62 (show GTF2H1 Antibodies) recruitment mechanism is shared by UV-stimulated scaffold protein A (UVSSA (show KIAA1530 Antibodies)) in transcription-coupled repair (TCR) and xeroderma pigmentosum, complementation group C protein (XPC) in global genome repair (GGR (show GCGR Antibodies)).
CHD1 (show CHD1 Antibodies) facilitates substrate handover from XPC to the downstream TFIIH (show GTF2H1 Antibodies) (transcription factor IIH).
results provide insights into an unexpected biological role of XPC in response to DNA replication stress
Allelic variants in the gene XPC are not associated with an increased risk for developing pre-senile cataract
XPC dissociation from the damage site could become a rate-limiting step in nucleotide excision repair (NER (show NR1H2 Antibodies)) of certain types of DNA adducts, leading to repression of NER (show NR1H2 Antibodies).
Histone deacetylation plays a significant role in the process of DNA damage recognition for nucleotide excision repair and the localization and functions of XPC can be regulated by acetylated states of histones.
The risk of esophageal squamous cell carcinoma associated with XPC rs-2228000 was determined. A homozygous minor allele showed strong association with ESCC risk, especially in smokers, those in adobe houses, and drinkers of salt tea. Variant genotypes of both XPA (show XPA Antibodies) and XPC in combination showed an increased risk towards ESCC.
the associations between three XPC gene polymorphisms (rs2228001 A>C, rs2228000 C>T, and rs2229090 G>C) and neuroblastoma risk with 256 neuroblastoma patients and 531 healthy controls in a Chinese Han population, were investigated.
results suggest that XPC may help repair DNA damage caused by KRAS-mediated production of ROS (show ROS1 Antibodies).
OCT4 (show POU5F1 Antibodies) and SOX2 (show SOX2 Antibodies) are the primary transcription factors recruiting SCC (show CYP11A1 Antibodies) to regulatory regions of pluripotency genes; the XPC subunit is essential for interaction with the two proteins
progerin and p16(INK4a) expression, beta-galactosidase (show GLB1 Antibodies) activity, and reactive oxygen species, which increase with age, were higher in young Xpc(-/-) mice than in young Xpc(+/+) ones
Study indicates that Xpc(-/-) mice have an increased mutational load upon induction of oxidative stress. The effect of non-functional XPC in vivo appears to have implications in mutagenesis, which can contribute to the carcinogenesis process.
The C-terminal region of Xpc is dispensable for the transcriptional activity of Oct3/4 (show POU5F1 Antibodies) in mouse embryonic stem cells.
BRAF (show BRAF Antibodies)(V600E) and ARF deletion synergize to inhibit nucleotide excision repair by epigenetically repressing XPC.
Dysmyelination not demyelination causes neurological symptoms in preweaned mice in a cs-b xp-c murine model of Cockayne syndrome
analysis of mHR23A/B double-mutant cells showed that HR23 proteins function in nucleotide excision repair by governing xeroderma pigmentosum group C protein stability via partial protection against proteasomal degradation
mutational hot spot is not at a dipyrimidine site and is apparently Xpc-specific, suggesting some form of non-dipyrimidine base damage is normally repaired in a manner distinct from conventional nucleotide excision repair, but that requires XPC protein
Deletion of Gadd45a (show GADD45A Antibodies) alone does not lead to increased lung tumors in mice, but coupled with an XPC deletion, it results in lung tumor progression
This gene encodes a component of the nucleotide excision repair (NER) pathway. There are multiple components involved in the NER pathway, including Xeroderma pigmentosum (XP) A-G and V, Cockayne syndrome (CS) A and B, and trichothiodystrophy (TTD) group A, etc. This component, XPC, plays an important role in the early steps of global genome NER, especially in damage recognition, open complex formation, and repair protein complex formation. Mutations in this gene or some other NER components result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene.
xeroderma pigmentosum, complementation group C
, DNA repair protein complementing XP-C cells
, mutant xeroderma pigmentosum group C
, DNA repair protein complementing XP-C cells homolog
, xeroderma pigmentosum group C-complementing protein homolog