IL-36beta (human) Matched Pair Detection Set

Details for Product No. ABIN6253509
Antigen
  • 2310043N20Rik
  • Il36b
  • FIL1
  • FIL1-(ETA)
  • FIL1H
  • FILI-(ETA)
  • IL-1F8
  • IL-1H2
  • IL1-ETA
  • IL1F8
  • IL1H2
  • Il1f8
  • interleukin 1 family, member 8
  • interleukin 36 beta
  • interleukin 36, beta
  • Il1f8
  • IL36B
  • Il36b
Reactivity
Human
Detection Method
Colorimetric
Host
Mouse, Rabbit
Method Type
Sandwich ELISA
Detection Range
15.6 pg/mL - 1000 pg/mL
Minimum Detection Limit
15.6 pg/mL
Application
ELISA
Options
Purpose IL-36beta (human) Matched Pair Detection Set
Detection Method Colorimetric
Sensitivity 10 pg/mL
Characteristics Matched Pair Detection Set. Detects human IL-36beta in cell culture supernatant. Colorimetric assay. Sample Type: Cell Culture Supernatant. Range: 15.6 to 1000 pg/mL. Sensitivity: 10 pg/mL. IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination.
Components 1 vial standard protein (100ng) (lyophilized) [STD] 1 vial coating antibody (270μl) [COAT] 1 vial detection antibody (60μl) [DET] 1 vial streptavidin-HRP (10μg) (lyophilized) [STREP]
Antigen
Alternative Name IL-36beta
Background

Alternate Names/Synonyms: Interleukin-36beta Interleukin-1 Family Member 8, IL-1F8

Product Description: IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination.

Restrictions For Research Use only
Handling Advice Avoid freeze/thaw cycles.
Storage -20 °C
Storage Comment

Short Term Storage: -20°C

Long Term Storage: -20°C

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.