IL-36beta (human) Matched Pair Detection Set
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- Target See all FIL1h products
- FIL1h (Interleukin 1 eta (FIL1h))
- Reactivity
- Human
- Detection Method
- Colorimetric
- Host
- Mouse, Rabbit
- Method Type
- Sandwich ELISA
- Detection Range
- 15.6 pg/mL - 1000 pg/mL
- Minimum Detection Limit
- 15.6 pg/mL
- Application
- ELISA
- Purpose
- IL-36beta (human) Matched Pair Detection Set
- Sensitivity
- 10 pg/mL
- Characteristics
- Matched Pair Detection Set. Detects human IL-36beta in cell culture supernatant. Colorimetric assay. Sample Type: Cell Culture Supernatant. Range: 15.6 to 1000 pg/mL. Sensitivity: 10 pg/mL. IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination.
- Components
- 1 vial standard protein (100ng) (lyophilized) [STD] 1 vial coating antibody (270μl) [COAT] 1 vial detection antibody (60μl) [DET] 1 vial streptavidin-HRP (10μg) (lyophilized) [STREP]
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- Restrictions
- For Research Use only
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- Concentration
- Lot specific
- Handling Advice
- Avoid freeze/thaw cycles.
- Storage
- -20 °C
- Storage Comment
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Short Term Storage: -20°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.
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- Target
- FIL1h (Interleukin 1 eta (FIL1h))
- Alternative Name
- IL-36beta (FIL1h Products)
- Synonyms
- 2310043N20Rik Matched Antibody Pair, Il36b Matched Antibody Pair, FIL1 Matched Antibody Pair, FIL1-(ETA) Matched Antibody Pair, FIL1H Matched Antibody Pair, FILI-(ETA) Matched Antibody Pair, IL-1F8 Matched Antibody Pair, IL-1H2 Matched Antibody Pair, IL1-ETA Matched Antibody Pair, IL1F8 Matched Antibody Pair, IL1H2 Matched Antibody Pair, Il1f8 Matched Antibody Pair, interleukin 1 family, member 8 Matched Antibody Pair, interleukin 36 beta Matched Antibody Pair, interleukin 36, beta Matched Antibody Pair, Il1f8 Matched Antibody Pair, IL36B Matched Antibody Pair, Il36b Matched Antibody Pair
- Background
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Alternate Names/Synonyms: Interleukin-36beta Interleukin-1 Family Member 8, IL-1F8
Product Description: IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination.
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