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anti-Human GATA4 Antibodies:
anti-Mouse (Murine) GATA4 Antibodies:
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Human Polyclonal GATA4 Primary Antibody for IF, IHC - ABIN6712236
Shu, Chen, Zhang, Guo, Zhou, Zong, Bian, Dong, Dai, Zhang, Tang: Gastrodin protects against cardiac hypertrophy and fibrosis. in Molecular and cellular biochemistry 2012
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Human Polyclonal GATA4 Primary Antibody for ELISA, WB - ABIN543442
Philips, Kwok, Chong: Analysis of the signals and mechanisms mediating nuclear trafficking of GATA-4. Loss of DNA binding is associated with localization in intranuclear speckles. in The Journal of biological chemistry 2007
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Human Monoclonal GATA4 Primary Antibody for ELISA, WB - ABIN969169
Rajagopal, Ma, Obler, Shen, Manichaikul, Tomita-Mitchell, Boardman, Briggs, Garg, Srivastava, Goldmuntz, Broman, Benson, Smoot, Pu: Spectrum of heart disease associated with murine and human GATA4 mutation. in Journal of molecular and cellular cardiology 2007
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Human Monoclonal GATA4 Primary Antibody for ELISA, WB - ABIN4313655
Sato, Okumura, Ariga, Hatakeyama: TRIM6 interacts with Myc and maintains the pluripotency of mouse embryonic stem cells. in Journal of cell science 2012
Human Monoclonal GATA4 Primary Antibody for IF, IHC - ABIN2721730
Yang, Chen, Kaushal, Reece, Yang: High glucose suppresses embryonic stem cell differentiation into cardiomyocytes : High glucose inhibits ES cell cardiogenesis. in Stem cell research & therapy 2017
Human Monoclonal GATA4 Primary Antibody for WB - ABIN2721731
Huang, Chen, Hwang, Yu, Su, Mai, Wang, Cheng, Schuyler, Ma, Lu, Lu: miR-200c and GATA binding protein 4 regulate human embryonic stem cell renewal and differentiation. in Stem cell research 2014
Data show that GATA4 or 6 regulate both cardiogenic potential and subsequent cardiomyocyte differentiation but that GATA5 is involved in regulating cardiomyocyte differentiation.
Results describe the expression of GATA4 and 6 during gastrulation and their function in migratory behaviour.
The data demonstrate that KLF13 is an important component of the transcription network required for heart development and suggest that KLF13 is a GATA-4 modifier
Data show that GATA4 knockdown only affects cardiac marker expression in the absence of either GATA5 or GATA6, suggesting redundancy in this family during myocardial development.
These results indicate a higher capacity of adipose-derived than bone marrow-derived mesenchymal stem cells to express GATA4.
the DNA variants may alter GATA4 gene promoter activity and affect GATA4 levels, thus contributing to AMI development.
Two GATA4 SNPs rs368418329, rs56166237 are associated with congenital heart disease in Egyptian children.
The aim of this study was to screen a Moroccan cohort with tetralogy of Fallot for GATA4 mutations, and to assess environmental risk factors that could be involved in the occurrence of this disorder.
Study demonstrates that GATA4 functions as a tumor suppressor in lung cancer. Mechanistically, GATA4 upregulates multiple miRNAs targeting TGFB2 mRNA and causes ensuing WNT7B downregulation and eventually triggers cell senescence. Targeting the TGF-beta signaling provides a potential way for the treatment of GATA4-deficient lung cancer.
Comprehensive computational analysis, using well-established web based tools, is suggestive of their potential downstream molecular effects on the structure, stability and expression of GATA4 protein
abnormal lamin. proteins trigger paracrine senescence through GATA4-dependent pathway in human mesenchymal stem cells.
The findings support the fact that rare functional variants especially in GATA4 could be associated with BAV, adding novel genetic factors to the list of variants associated with the phenotypic expression of this genetically complex pathology.
we found two known SNPs (rs56166237, rs3729856) in GATA4. Our study shows no evidence of NKX2-5 and GATA4 somatic mutations playing a role in the pathogenesis of sporadic Congenital Heart Disease.
data indicate that GATA4 gene might play a role in cell proliferation and differentiation during the progression of pancreatic cancer.
findings demonstrate that RACK1 is involved in p300/GATA4-dependent hypertrophic responses in cardiomyocytes and is a promising therapeutic target for heart failure
Studied prevalence of GATA binding protein 4 (GATA4) exon 1 mutation in Egyptian patients with isolated congenital heart defects.
The single nucleotide polymorphisms (SNPs) of NKX2.5, GATA4, and TBX5 are highly associated with congenital heart diseases in the Chinese population, but not significant in the SNPs of FOG2.
direct binding of GATA4 to the GNAI3 promoter, both in vitro and in vivo, is reported.
Report a genome-wide association scan of 466 bicuspid aortic valve cases and 4,660 age, sex and ethnicity-matched controls with replication in up to 1,326 cases and 8,103 controls. We identify association with a noncoding variant 151 kb from the gene encoding the cardiac-specific transcription factor, GATA4, and near-significance for p.Ser377Gly in GATA4.
GATA4 variants were not associated with Alcohol Use Disorder (AUD) in either the European ancestry or African ancestry groups after correcting for multiple comparisons. Rs10112596 demonstrated a significant relationship with an anxiety measure among the African ancestry group with AUD.
High GATA4 expression is associated with mesenchymal and migratory phenotype of hepatoblastoma cells.
GATA4 may inhibit diabetesinduced endothelial dysfunction by acting as a transcription factor for NOX4 expression.
GATA4 acetylation activated CCND2 transcription, and mutation of GATA4 on K-313 reduced cell viability and increased a mitochondria-dependent apoptosis.
we found two nucleotide deletions which one of them was novel and one new indel mutation resulting in frame shift mutation, and 4 synonymous variations or polymorphism in 6 of patients and 3 of normal individuals
the mutation significantly diminished the synergistic activation between MEF2C and GATA4, another cardiac core transcription factor that has been causally linked to Congenital heart disease (CHD).
investigation of genes regulated by GATA4, GATA6, and both in combination: studies in granulosa cells primed for luteinization
GATA-4 and C/EBPbeta are both required for FSH +/- IGF-I stimulation of the porcine steroidogenic acute regulatory protein gene promoter in homologous granulosa cell cultures.
The altered ratio of GATA4 to GATA6 after ovulation may allow GATA6 to enhance STAR mRNA accumulation.
Data indicate a function of GATA binding protein 4 (GATA4) as a cardiac repressor of the transcription factor 7-like 2 protein (TCF7L2)/beta-catenin complex.
GATA4 directly represses RANKL expression via seven cis-regulatory regions and plays an important role in maintaining proper bone development and osteoclast formation.
Meox1 accelerated myocardial hypertrophic decompensation via the downstream target Gata4, at least in part directly.
inhibitory action of GATA4 on testicular peritubular myoid cell contraction mediated at least partly by regulating genes belonging to smooth muscle contraction pathway
miR-429 expression levels were upregulated in cultured neurons with OGD/R treatment. The downregulation of miR-429 significantly alleviated oxygen-glucose deprivation and reoxygenation-induced neuronal injury, whereas upregulation of miR-429 aggravated it. miR-429 could directly target the 3'-untranslated region of GATA4. miR-429 negatively regulated GATA4 expression.
Rere and Gata4 interact genetically in the development of congenital heart defects.
Downregulation of Gata4 could restore the phenotype exhibited by Wnt3 downregulation in dorsal root ganglion neurons.
Enrichment of induced cardiomyocytes derived from mouse fibroblasts can be achieved by reprogramming with cardiac transcription factors, Gata4, MEF2c, Tbx5, and Hand2.
GATA4/6 are key regulators of steroidogenesis and testicular somatic cell survival.
Observations identify Gata4 as a novel crucial regulator of the intestinal epithelial barrier and as a critical epithelial transcription factor implicated in the maintenance of proximal intestinal mucosal integrity after injury.
Gata4 mutants also demonstrated Hedgehog (Hh) signaling defects.
disruption of GATA4-mediated transactivation in hepatocellular carcinoma suppresses hepatocyte epithelial differentiation to sustain replicative precursor phenotype
Mechanistically, decreased GATA4 levels caused the downregulation of several pro-regenerative genes (among them interleukin-13, Il13) in the myocardium.
GATA4 acts as master regulator of hepatic microvascular specification and acquisition of organ-specific vascular competence, which are indispensable for liver development.
study provides novel insights into the role of WT1 and GATA4 during the sex differentiation phase and represents an approach that can be applied to assess other proteins with as yet unknown functions during gonadal development
we have identified a distinct lineage of adult HSCs characterized by its derivation of progenitors where Gata4 expression is activated by a specific enhancer. Most adult HSCs belonging to this lineage probably originate in the placenta.
Histone acetylation/methylation and DNA methylation were both involved in regulating GATA4 expression, but Nkx2.5 expression was not regulated by DNA methylation. These three modifications had high correlation with each other during regulation of GATA4 and produced a regulation loop at the GATA4 promoter.
GATA4 acts as a negative regulator of Bsp expression in osteoblasts.
Detailed analysis of specific lineage markers expression showed selective downregulation of endoderm markers in REST-null cells, thus contributing to a loss of cardiogenic signals. REST regulates cardiac differentiation of ESCs by negatively regulating the Wnt/beta-catenin signaling pathway and positively regulating the cardiogenic TF Gata4
The activity of Gata4 cardiac enhancer in transgenic embryos and in cultured aortic endothelial cells is dependent on four ETS sites.
Study finds that emergent juvenile cortical cardiomyocytes induce expression of gata4 in a manner similar to during regeneration.
ATOH8, GATA4, and FOG2 associate in a single complex
gata4 gene regulates sdf1a levels during early embryogenesis
mga restricts the normal levels of Gata4 required for heart tube looping.
Through the use of a transgenic reporter strain, we found that cardiomyocytes throughout the subepicardial ventricular layer trigger expression of the embryonic cardiogenesis gene gata4 within a week of trauma
Gata4 and Gata6 have distinct non-redundant functions in cardiac morphogenesis, but are redundant for an early step of liver development; and Gata4 and Gata6 are essential and non-redundant for liver growth following initial budding
Results suggest that GATA4 and -6 play a key role in the regulation of ventricular myosin heavy chain gene expression in the ventricle.
This gene encodes a member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function. Mutations in this gene have been associated with cardiac septal defects.
GATA binding protein 4
, glutamyl-tRNA(Gln) amidotransferase subunit A
, GATA-4 zinc-finger transcription factor
, gata4 transcription factor
, GATA-4 transcription factor
, GATA-binding factor 4
, transcription factor GATA-4
, GATA-binding protein 4
, DNA-binding protein GATA-GT2
, transcription factor GATA4
, transcription factor xGATA-4