Browse our anti-GATA4 (GATA4) Antibodies

Xenopus laevis GATA Binding Protein 4 (GATA4) interaction partners

1. Data show that GATA4 or 6 regulate both cardiogenic potential and subsequent cardiomyocyte differentiation but that GATA5 is involved in regulating cardiomyocyte differentiation.

2. Results describe the expression of GATA4 and 6 during gastrulation and their function in migratory behaviour.

3. The data demonstrate that KLF13 (show KLF13 Antibodies) is an important component of the transcription network required for heart development and suggest that KLF13 (show KLF13 Antibodies) is a GATA-4 modifier

4. Data show that GATA4 knockdown only affects cardiac marker expression in the absence of either GATA5 or GATA6, suggesting redundancy in this family during myocardial development.

Rabbit GATA Binding Protein 4 (GATA4) interaction partners

1. These results indicate a higher capacity of adipose-derived than bone marrow-derived mesenchymal stem cells to express GATA4.

Human GATA Binding Protein 4 (GATA4) interaction partners

1. This report demonstrates that GATA4 promotes oncogenesis by inhibiting miR125b-dependent suppression of DKK3 expression. This GATA4/miR125b/DKK3 axis may be a major regulator of growth, migration, invasion, and survival in hepatoma cells.

2. although relatively infrequent in patients with hypertrophic cardiomyopathy, GATA2 (show GATA2 Antibodies), 4 and 6 transcription factors may represent a novel insight into the molecular mechanisms related to the pathogenesis of hypertrophic cardiomyopathy

3. study found that the formation of pancreatic progenitors cells is highly sensitive to the GATA6 (show GATA6 Antibodies) and GATA4 gene dosage

4. when ZFPM2R698Q was co-transfected with GATA4, BNP (show BNC2 Antibodies) promoter activity increased significantly, whereas co-transfection with ZFPM2R736L and GATA4 did not significantly increase BNP (show BNC2 Antibodies) promoter activity. This suggests that the R698Q mutation may affect the ability of ZFPM2 (show ZFPM2 Antibodies) to bind GATA4.

5. GATA4 is a regulator of osteoblastic differentiation via the p38 (show CRK Antibodies) signaling pathways.

6. miR (show MLXIP Antibodies)-126 inhibits the migration and invasion of glioma cells, which may be linked to GATA4 as a target gene.

7. Study identified effects of GATA4 variant [(SNP) rs13273672] on regional gray matter (GM) volume in alcohol dependence: higher GM volume in the hypothalamus and caudate in the AA genotype group compared to the AG/GG group. GM volume specific to GATA4 variant predicted heavy relapse risk within 60 d following discharge for both caudate and amygdala and within 90 d for the amygdala only.

8. The role of GATA4 was elucidated in alcohol dependence susceptibility by identifying rare genetic variants.

9. disruption of GATA4-mediated transactivation in hepatocellular carcinoma suppresses hepatocyte epithelial differentiation to sustain replicative precursor phenotype

10. This study attempts to correlate the pattern of intronic variants of GATA4 gene which might provide new insights to unravel the possible molecular etiology of congenital heart disease.

Pig (Porcine) GATA Binding Protein 4 (GATA4) interaction partners

1. investigation of genes regulated by GATA4, GATA6 (show GATA6 Antibodies), and both in combination: studies in granulosa cells primed for luteinization

2. GATA-4 and C/EBPbeta (show CEBPB Antibodies) are both required for FSH (show BRD2 Antibodies) +/- IGF-I (show IGF1 Antibodies) stimulation of the porcine steroidogenic acute regulatory protein (show STAR Antibodies) gene promoter in homologous granulosa cell cultures.

3. The altered ratio of GATA4 to GATA6 (show GATA6 Antibodies) after ovulation may allow GATA6 (show GATA6 Antibodies) to enhance STAR mRNA accumulation.

Mouse (Murine) GATA Binding Protein 4 (GATA4) interaction partners

1. Gata4 mutants also demonstrated Hedgehog (show SHH Antibodies) (Hh) signaling defects.

2. disruption of GATA4-mediated transactivation in hepatocellular carcinoma suppresses hepatocyte epithelial differentiation to sustain replicative precursor phenotype

3. Mechanistically, decreased GATA4 levels caused the downregulation of several pro-regenerative genes (among them interleukin-13 (show IL13 Antibodies), Il13 (show IL13 Antibodies)) in the myocardium.

4. GATA4 acts as master regulator of hepatic microvascular specification and acquisition of organ-specific vascular competence, which are indispensable for liver development.

5. study provides novel insights into the role of WT1 (show WT1 Antibodies) and GATA4 during the sex differentiation phase and represents an approach that can be applied to assess other proteins with as yet unknown functions during gonadal development

6. we have identified a distinct lineage of adult HSCs characterized by its derivation of progenitors where Gata4 expression is activated by a specific enhancer. Most adult HSCs belonging to this lineage probably originate in the placenta.

7. Histone acetylation/methylation and DNA methylation (show HELLS Antibodies) were both involved in regulating GATA4 expression, but Nkx2.5 (show NKX2-5 Antibodies) expression was not regulated by DNA methylation (show HELLS Antibodies). These three modifications had high correlation with each other during regulation of GATA4 and produced a regulation loop at the GATA4 promoter.

8. GATA4 acts as a negative regulator of Bsp (show KLK6 Antibodies) expression in osteoblasts.

9. Detailed analysis of specific lineage markers expression showed selective downregulation of endoderm markers in REST-null cells, thus contributing to a loss of cardiogenic signals. REST regulates cardiac differentiation of ESCs (show NR2E3 Antibodies) by negatively regulating the Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling pathway and positively regulating the cardiogenic TF Gata4

10. GATA4 and GATA6 (show GATA6 Antibodies) are essential for female fertility, whereas targeting either factor alone causes subfertility. GATA4 and GATA6 (show GATA6 Antibodies) are also required for the expression of the receptors for prolactin (show PRL Antibodies) and luteinizing hormone.

Cow (Bovine) GATA Binding Protein 4 (GATA4) interaction partners

1. The activity of Gata4 cardiac enhancer in transgenic embryos and in cultured aortic endothelial cells is dependent on four ETS (show ETS1 Antibodies) sites.

Zebrafish GATA Binding Protein 4 (GATA4) interaction partners

1. Study finds that emergent juvenile cortical cardiomyocytes induce expression of gata4 in a manner similar to during regeneration.

2. ATOH8 (show ATOH8 Antibodies), GATA4, and FOG2 (show ZFPM2 Antibodies) associate in a single complex

3. gata4 gene regulates sdf1a (show CXCL12 Antibodies) levels during early embryogenesis

4. mga (show MGA Antibodies) restricts the normal levels of Gata4 required for heart tube looping.

5. Through the use of a transgenic reporter strain, we found that cardiomyocytes throughout the subepicardial ventricular layer trigger expression of the embryonic cardiogenesis gene gata4 within a week of trauma

6. Gata4 and Gata6 (show GATA6 Antibodies) have distinct non-redundant functions in cardiac morphogenesis (show XIRP1 Antibodies), but are redundant for an early step of liver development; and Gata4 and Gata6 (show GATA6 Antibodies) are essential and non-redundant for liver growth following initial budding

7. Data show that GATA4 knockdown only affects cardiac marker expression in the absence of either GATA5 (show GATA6 Antibodies) or GATA6 (show GATA6 Antibodies), suggesting redundancy in this family during myocardial development.

8. Results suggest that GATA4 and -6 play a key role in the regulation of ventricular myosin heavy chain gene expression in the ventricle.