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Thus, the adipogenic action of exogenous unacylated ghrelin in tibial marrow is dependent upon acylation by GOAT and activation of GHS-R1a.
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the effect of GOAT on gastric acid secretion and expression of ghrelin in vitro, were investigated.
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Gene browse revealed QTL for body weight/size, genes involved in immune system, and two main protein-coding genes involved in the Glucose homeostasis, Mboat4 and Leprotl1. Heritability and coefficient of genetic variance (CVg) were 0.49 and 0.31 for females, while for males, these values 0.34 and 0.22, respectively.
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GOAT immunoreactivity is aggregated at the base of the dentate granule cell layer in wild-type mice. This was not affected by the pharmacological inhibition of GHSR1a or the metabolic state-dependent fluctuation of systemic ghrelin levels. But it was absent in the GHSR1a knockout mouse hippocampus, implying that the expression of GHSR1a may be a prerequisite for the production of GOAT.
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Both ghrelin and GOAT are localized primarily in the red pulp of the spleen. Importantly, in the thymus, ghrelin was predominantly localized to the medulla, whereas GOAT was found in the cortex, implying differing roles in T cell development. Both regulates obesity-induced inflammation.
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anxiogenic actions of GOAT deletion not related to high plasma des-acyl ghrelin
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GOAT knock-out pregnant mice on calorie-restricted diet are more prone to hypoglycemia than wild type.
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circadian rhythmicity of ghrelin signaling requires Bmal1 and is driven by a food-responsive clock in the gastric ghrelin-secreting cell that not only regulates ghrelin, but also GOAT activity.
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observations demonstrate that germline loss of ghrelin-O-acyltransferase alters Growth Hormone release and patterning
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Altered lipid and salt taste responsivity in ghrelin and GOAT null mice.
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The absence of GOAT does not alter glucose intolerance suggesting that desacyl/acyl ghrelin is not a major denominator for glucose homeostasis.
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The absence of the enzyme GOAT does not play a significant role in maintenance of body core temperature or metabolic adaptation during exposure to low external temperatures.
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GOAT induced ghrelin acylation regulates hedonic feeding.
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The endogenous GOAT-ghrelin-growth hormone secretagogue receptor system is not essential for the maintenance of euglycemia during prolonged calorie restriction.
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While there is considerable overlap in expression pattern between ghrelin and ghrelin O-acyltransferase (GOAT), the latter exhibits some unique tissue expression that could suggest that additional peptides may be acylated and await discovery.(Review)
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This is the first report that the GOAT/ghrelin system regulates bile acid metabolism, and these findings suggest a novel function of GOAT in the regulation of intestinal bile acid reabsorption..
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Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice
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The present study demonstrates that stomach GOAT mRNA levels correlate with circulating acylated-ghrelin levels in fasted and diet-induced obese mice.
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These data suggest species differences between rats and mice in gastric GOAT expression perhaps resulting in a different role of the MBOAT4 enzyme in the rat stomach.
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The presence of PC and GOAT in the cells, as well as n-octanoic acid in the culture medium, was necessary to produce n-octanoyl ghrelin.
