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Human Polyclonal MBOAT4 Primary Antibody for IF (p), IHC (p) - ABIN1714457
Yu, Chu, Chen, Hsieh, Kuo: Mediation of oxidative stress in hypothalamic ghrelin-associated appetite control in rats treated with phenylpropanolamine. in Genes, brain, and behavior 2016
Show all 2 Pubmed References
Human Polyclonal MBOAT4 Primary Antibody for ELISA, WB - ABIN4274728
Takahashi, Ida, Sato, Nakashima, Nakamura, Tsuji, Kojima: Production of n-octanoyl-modified ghrelin in cultured cells requires prohormone processing protease and ghrelin O-acyltransferase, as well as n-octanoic acid. in Journal of biochemistry 2009
Plasma GOAT levels exhibit high specificity/sensitivity to predict prostate carcinoma-presence compared with other PCa (show FLVCR1 Antibodies)-biomarkers, especially in non-diabetic individuals.
The role of ghrelin O-acyltransferase cysteine residue in the ghrelin (show GHRL Antibodies) acylation
GOAT prefers n-hexanoyl-CoA over n-octanoyl-CoA as the acyl donor, although in the stomach the n-octanoyl form is the predominant form of acyl-modified ghrelin (show GHRL Antibodies).
The GOAT active site was characterized by defining substrate-enzyme interactions used to bind and recognize ghrelin (show GHRL Antibodies).
Studies suggest that dysregulation in the components of the ghrelin (show GHRL Antibodies) system including ghrelin (show GHRL Antibodies), ghrelin receptor (show GHSR Antibodies) (GHSR1a) and ghrelin (show GHRL Antibodies)-O-acyl-transferase can lead to or influence the development and/or progression of highly concerning pathologies.
Architectural organization of the metabolic regulatory enzyme ghrelin O-acyltransferase.
Data indicate that ghrelin O-acyltransferase (GOAT) mRNA and protein are expressed in the normal prostate and prostate cancer tissue samples.
Genetic variation of the ghrelin (show GHRL Antibodies) activator gene ghrelin O-acyltransferase (GOAT) is associated with anorexia nervosa. (Review)
Identification of GOAT expression in various tissues support the concept that in addition to the important endocrine effect of acylated ghrelin (show GHRL Antibodies), the paracrine effects of locally synthetised and acylated ghrelin (show GHRL Antibodies) may be important.
Modulation of GOAT or ghrelin (show GHRL Antibodies) signaling may be a clinically relevant strategy to treat metabolic diseases such as type II diabetes.
Gene browse revealed QTL for body weight/size, genes involved in immune system, and two main protein-coding genes involved in the Glucose homeostasis, Mboat4 and Leprotl1 (show LEPROTL1 Antibodies). Heritability and coefficient of genetic variance (CVg) were 0.49 and 0.31 for females, while for males, these values 0.34 and 0.22, respectively.
GOAT immunoreactivity is aggregated at the base of the dentate granule cell layer in wild-type mice. This was not affected by the pharmacological inhibition of GHSR1a or the metabolic state-dependent fluctuation of systemic ghrelin (show GHRL Antibodies) levels. But it was absent in the GHSR1a knockout mouse hippocampus, implying that the expression of GHSR1a may be a prerequisite for the production of GOAT.
Both ghrelin (show GHRL Antibodies) and GOAT are localized primarily in the red pulp of the spleen. Importantly, in the thymus, ghrelin (show GHRL Antibodies) was predominantly localized to the medulla, whereas GOAT was found in the cortex, implying differing roles in T cell development. Both regulates obesity-induced inflammation.
anxiogenic actions of GOAT deletion not related to high plasma des (show DES Antibodies)-acyl ghrelin (show GHRL Antibodies)
circadian rhythmicity of ghrelin (show GHRL Antibodies) signaling requires Bmal1 (show ARNTL Antibodies) and is driven by a food-responsive clock in the gastric ghrelin (show GHRL Antibodies)-secreting cell that not only regulates ghrelin (show GHRL Antibodies), but also GOAT activity.
observations demonstrate that germline loss of ghrelin-O-acyltransferase alters Growth Hormone release and patterning
Altered lipid and salt taste responsivity in ghrelin (show GHRL Antibodies) and GOAT null mice.
The absence of GOAT does not alter glucose intolerance suggesting that desacyl/acyl ghrelin (show GHRL Antibodies) is not a major denominator for glucose homeostasis.
GOAT induced ghrelin (show GHRL Antibodies) acylation regulates hedonic feeding.
The endogenous GOAT-ghrelin-growth hormone secretagogue receptor (show GHSR Antibodies) system is not essential for the maintenance of euglycemia during prolonged calorie restriction.
Mediates the octanoylation of ghrelin at 'Ser-3'. Can use a variety of fatty acids as substrates including octanoic acid, decanoic acid and tetradecanoic acid.
O-acyltransferase (membrane bound) domain containing 4
, O-acyltransferase domain-containing protein 4
, ghrelin O-acyltransferase
, membrane-bound O-acyltransferase domain-containing protein 4