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Bat Polyclonal PCSK2 Primary Antibody for WB - ABIN611197
Discher, Bishopric, Wu, Peterson, Webster: Hypoxia regulates beta-enolase and pyruvate kinase-M promoters by modulating Sp1/Sp3 binding to a conserved GC element. in The Journal of biological chemistry 1998
Show all 3 Pubmed References
Human Polyclonal PCSK2 Primary Antibody for IF (p), IHC (p) - ABIN1385997
van Rijn, Pouwer, Tryfonidou, Grinwis, van der Bend, Beukers, Vastenhout, Drouin, Penning, Meij: Expression and clinical relevance of paired box protein 7 and sex determining region Y-box 2 in canine corticotroph pituitary adenomas. in Veterinary journal (London, England : 1997) 2015
PCSK2 gene polymorphisms are associated with pleiotropic effects on various traits of glucose homeostasis and incident diabetes.
FAM20C (show FAM20C Antibodies) plays a role in 7B2 (show SCG5 Antibodies)-mediated proPC2 activation by phosphorylating residue Thr111; and that 7B2 (show SCG5 Antibodies) function is regulated by alternative splicing.
in the processing of hypothalamic neuropeptides in huntington disease (show HTT Antibodies) may partially arise from decreased PC1/3 (show PCSK1 Antibodies) and PC2 (show KRT6B Antibodies) expressions.
variant of the PCSK2 gene was associated with reduced glucose-stimulated insulin (show INS Antibodies) secretion, but also with lower glucagon (show GCG Antibodies) levels, which could potentially counteract the effects of decreased insulin (show INS Antibodies) secretion on the risk of type 2 diabetes
The association of risk allele rs2021785 at PCSK2 with type 2 diabetes exists in a Han Chinese population
differential gene expression profiles revealed more abundant mRNA expression in ectopic ACTH (show POMC Antibodies) syndrome than in Cushing disease of proprotein convertase-2
PC1/3 (show PCSK1 Antibodies) governs the endocrine, and PC2 (show KRT6B Antibodies) the neuronal processing, of proCCK, whereas PC5 (show PCSK5 Antibodies)/6 contributes only to a modest endocrine synthesis of CCK-22 (show CCK Antibodies).
SEMA3F (show SEMA3F Antibodies), CLEC16A (show CLEC16A Antibodies), LAMA3 (show LAMA3 Antibodies), and PCSK2 variants have roles in myocardial infarction in Japanese individuals
The presence of PC and GOAT in the cells, as well as n-octanoic acid in the culture medium, was necessary to produce n-octanoyl ghrelin (show GHRL Antibodies).
prominently expressed in PTHrP-expressing human cancer cell lines originating from tumors of the breast, lung, prostate, as well as lymphoma
Prohormone convertase PC2 expression is up-regulated in a cell-specific manner in bovine neuroendocrine ocular ciliary epithelium.
Pcsk2 has been sequenced and characterized.
Study reveals a significant reduction of tachykinin and opioid neuropeptides level in proprotein convertase 1 (show PCSK1 Antibodies) and proprotein convertase 2 mutant mouse spinal cords.
Study reports that PC2 (show CBX4 Antibodies) null mice had increased number of mu opioid receptors in different brain areas. These mice also exhibited enhanced morphine-induced antinociception but reduced tolerance to and dependence on morphine.
PC1 (show PCSK1 Antibodies) and PC2 (show CBX4 Antibodies) are involved in the C-terminal processing of protachykinin peptides and suggest a major role in the maturation of the protachykinin-1 (show TAC1 Antibodies) protein
activation of the hypothalamic GPR40 (show FFAR1 Antibodies)/FFA1 signaling pathway may regulate beta-endorphin (show POMC Antibodies) release via PC2 (show CBX4 Antibodies), and regulate the endogenous pain control system
Verified the roles of proprotein convertase subtilisin/kexin type 2 in regulating IGF1 (show IGF1 Antibodies) and female sexual maturation, it also might be involved in the regulation of aging.
Islets of Langerhans from prohormone convertase-2 knockout mice show alpha-cell hyperplasia and tumorigenesis with elevated alpha-cell neogenesis.
Pc2 (show CBX4 Antibodies) activity can be downregulated by mutant PAX6 (show PAX6 Antibodies).
PC2 (show CBX4 Antibodies) alone is responsible for catalyzing the conversion of pFE (show PTH1R Antibodies)(22) to pFQ(7) and pSE(14), all peptides implicated in regulation of suckling-induced prolactin (show PRL Antibodies) release.
Dynamic modulation of prohormone convertase 2 (PC2)-mediated precursor processing by 7B2 (show SCG5 Antibodies) protein has a preferential effect on glucagon (show GCG Antibodies) synthesis
PCSK2 is needed for normal food intake and processing
This gene encodes a member of the subtilisin-like proprotein convertase family. These enzymes process latent precursor proteins into their biologically active products. The encoded protein plays a critical role in hormone biosynthesis by processing a variety of prohormones including proinsulin, proopiomelanocortin and proluteinizing-hormone-releasing hormone. Single nucleotide polymorphisms in this gene may increase susceptibility to myocardial infarction and type 2 diabetes. This gene may also play a role in tumor development and progression. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
KEX2-like endoprotease 2
, neuroendocrine convertase 2
, prohormone convertase 2
, NEC 2
, proprotein convertase 2
, proprotein convertase subtilisin/kexin type 2
, proprotein convertase type 2
, convertase PC2
, proprotein convertase subtilisin/kexin type 2 L homeolog
, prohormone convertase2