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results suggest that SPC18 is involved in tumor progression, and is an independent prognostic classifier in patients with colorectal cancer
SPC18 contributes to malignant progression through promotion of TGF-alpha (show TGFA Proteins) secretion in gastric cancer.
This gene encodes a member of the peptidase S26B family. The encoded protein is an 18kDa subunit of the signal peptidase complex and has been linked to cell migration and invasion, gastric cancer and lymph node metastasis. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8.
SEC11-like protein 1
, SPase 18 kDa subunit
, endopeptidase SP18
, microsomal signal peptidase 18 kDa subunit
, signal peptidase complex (18kD)
, signal peptidase complex catalytic subunit SEC11A
, Sec11-like 1
, sid 2895
, signal peptidase complex 18kD
, signal peptidase 18 subunit
, SEC11-like 1
, microsomal signal peptidase complex