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There was a significant increase in protein levels of ZnT5 in the prefrontal cortex in Major depression disorder, relative to control subjects.
Overexpression of ZnT5 is accompanied by activation of PI3K/Akt pathway and inhibiting HG-induced apoptosis.
Results identify a unique class of transporters Znt5 and Znt8 and the structural motif required to discriminate between Zn(2+) and Cd(2+) transport.
exons 15 to 17 include a signal that results in trafficking of ZnT5 to the Golgi apparatus and that the 3' end of exon 14 includes a signal that leads to retention in the ER.
cloning and characterization of ZnT-5 which is expressed in pancreatic beta cells
A novel zinc-regulated human zinc transporter, hZTL1, is localized to the enterocyte apical membrane
hZnT-5 is up-regulated in response to cellular zinc depletion in Raji cells.
Data show that ZNT5 is extensively present in the Abeta-positive plaques in the cortex of human AD brains.
The cytosolic C-terminal tail of ZnT5 is important for its interaction with ZnT6 as a heterodimer.
results indicate that Znt5 protein plays an important role in maturation of osteoblasts and in maintenance of the cells involved in the cardiac conduction system, partly owing to dysregulated expression of IEGs and HSPs
ZnT5(-)ZnT7(-/-) cells showed exacerbation of the unfolded protein response as did the wild-type cells cultured under a zinc-deficient condition, revealing that both complexes play a role in homeostatic maintenance of secretory pathway function
Data suggest that Znt5 is selectively required for the mast cell-mediated delayed-type allergic response, and it is a novel player in mast cell activation.
This gene encodes a member of the SLC30A/ZnT family of zinc transporter proteins. ZnT proteins mediate both cellular zinc efflux and zinc sequestration into membrane-bound organelles. The encoded protein plays a role in the early secretory pathway as a heterodimer with zinc transporter 6, and may also regulate zinc sequestration into secretory granules of pancreatic beta cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 19.
zinc transporter 5
, solute carrier family 30 member 5
, solute carrier family 30 (zinc transporter), member 5
, zinc transporter ZTL1
, zinc transporter 5-like
, znT-like transporter 1
, zinc transporter like 1