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Some Autism spectrum disorder patients had haploidy of STX1A gene and lower STX1A gene expression.
Analysing protein mobility, cluster size and accessibility to myc (show MYC Antibodies)-epitopes the authors show that forces acting on the transmembrane segment produce loose clusters, while cytoplasmic protein (show BLZF1 Antibodies) interactions mediate a tightly packed state.
Our results suggest that, as in the CNS, CADM1 interactions drive exocytic site assembly and promote actin network formation. These results support the broader hypothesis that the effects of cell-cell contact on beta-cell maturation and function are mediated by the same extracellular protein interactions that drive the formation of the presynaptic exocytic machinery. These interactions may be therapeutic targets for re...
A significant interactive two-locus model of STX1A_rs4363087|VAMP2_rs2278637 (presynaptic genes) was observed among SVC (show COL4A1 Antibodies) variants in all epilepsy cases.
Mislocalization of syntaxin-1 was found in pluripotent stem cells from epileptic encephalopathy patient.
Blockade of the SNARE (show NAPA Antibodies) protein syntaxin 1 inhibits glioblastoma tumor growth.
SNARE (show NAPA Antibodies) complex genes and their interactions may play a significant role in susceptibility and working memory of ADHD.
We described clinical, genetic, and functional data from 17 families with a diagnosis of benign familial neonatal epilepsy caused by KCNQ2 (show KCNQ2 Antibodies) or KCNQ3 (show KCNQ3 Antibodies) mutations and we showed that some mutations lead to a reduction of Q2 channel regulation by syntaxin-1A.
no associaton with idiopathic generalized epilepsy was found regarding Intron 7 rs1569061 of Syntaxin 1A gene, MnlI rs3746544 and DdeI rs1051312 polymorphisms of SNAP-25 (show SNAP25 Antibodies) gene compared with healthy subjects
The clinical relevance of STX1A variants in CF
Syntaxin 1A drives fusion of large dense-core neurosecretory granules into a planar lipid bilayer
microdomains carrying syntaxin1/SNAP-25 (show SNAP25 Antibodies) and different types of calcium channels act as the sites for physiological granule fusion in "in situ" chromaffin cells
The role of syntaxin 1A in GLP1 (show GCG Antibodies) release from intestinal cells as a response to external stimuli is reported.
proteins, such as syntaxin-1, Munc18-1, or SNAP-25, modulate alpha-synuclein neuropathy and/or are dysregulated in Alzheimer's disease, understanding this type of neurodegeneration may provide new links between synaptic defects and neurodegeneration in humans
Therefore, our work provides insights into differential functions of Stx1 in neuronal maintenance and neurotransmission, with the latter explored further into its functions in vesicle docking and fusion.
Syn (show SYP Antibodies)-1A actions on newcomer SGs (show SKI Antibodies) were partly mediated by Syn (show SYP Antibodies)-1A interactions with newcomer SG VAMP8 (show VAMP8 Antibodies)
The results of this study suggested that STX1A plays an important role in social behavior through regulation of the OXTergic neural system.
Data suggest that porosome-associated proteins SNAP25 (show SNAP25 Antibodies), TREK-1 (show KCNK2 Antibodies), syntaxin-1A, and Gai3 exhibit stability and functionality such that isolated proteins can be reconstituted as insulin (show INS Antibodies)-secreting porosomes in cell membrane of live cells.
syntaxin 1 and vesicle-associated membrane protein 1 (show VAMP1 Antibodies) are more suitable targets to abolish functional soluble N-ethylmaleimide-sensitive factor attachment protein receptor (show VTI1B Antibodies) complexes
Data show a significant increase of vesicle-associated membrane protein 2 (VAMP-2 (show VAMP2 Antibodies)) mRNA expression, however, the expressions of synaptosome-associated protein of 25 kDa (SNAP-25 (show SNAP25 Antibodies)) and syntaxin 1A did not exhibit the changes in hippocampus.
Although STX1A and STX1B (show STX1B Antibodies) share a basic function as neuronal t-SNAREs, STX1B (show STX1B Antibodies) but not STX1A is necessary for the regulation of spontaneous and evoked synaptic vesicle exocytosis in fast transmission.
we found that STX1A and STX1B (show STX1B Antibodies) play distinct roles in neuronal survival using
The data demonstrate that polyphosphoinositide favors syntaxin1A trapping, and show that SNARE (show NAPA Antibodies) complex disassembly leads to syntaxin1A dissociation from presynaptic nanoclusters.
The authors found two syntaxin1A mutations that confer opposite general anesthesia phenotypes
Data suggest that Ca(2 (show CA2 Antibodies)+)-CaM regulation of V100 may control SNARE (show NAPA Antibodies) complex assembly for a subset of synaptic vesicles that sustain spontaneous release.
these results indicate that SNAP-25 (show SNAP25 Antibodies)-R206 and syntaxin (show STX4 Antibodies)-D253 play a major role in neuroexocytosis and support a radial assembly of several SNARE (show NAPA Antibodies) complexes interacting via the ionic couple formed by these two residues.
Syntaxin1A domain formation is induced by phosphoinositide-3,4,5-triphosphate; this clustering is dependent on positively charged residues in the juxtamembrane domain.
The Syx1A dependent trafficking of Grk (show GRK4 Antibodies) protein is required for efficient EGFR (show EGFR Antibodies) signaling during dorsal-ventral patterning.
analysis of epistatic interactions related to mutation of Syx1A
Syntaxin 1A molecules share a conserved threonine in C-terminal +7 layer near transmembrane domain. Mutation of threonine to isoleucine results in a structural change that resembles those found in syntaxins ascribed to the constitutive secretory pathway
This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE
neuron-specific antigen HPC-1
, synaptotagmin-associated 35 kDa protein
, syntaxin 1A (brain)-like
, syntaxin 1A (brain)
, syntaxin 1 a
, syntaxin 1
, syntaxin 1A
, syntx 1