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Roundabout, Axon Guidance Receptor, Homolog 1 (ROBO1) Peptide

ROBO1 Reactivity: Human Host: Rabbit BP
Catalog No. ABIN2764127
  • Target See all ROBO1 products
    ROBO1 (Roundabout, Axon Guidance Receptor, Homolog 1 (ROBO1))
    Origin
    Human
    Source
    • 6
    Rabbit
    Application
    Blocking Peptide (BP)
  • Restrictions
    For Research Use only
  • Storage
    -20 °C
  • Target
    ROBO1 (Roundabout, Axon Guidance Receptor, Homolog 1 (ROBO1))
    Background
    Receptor for SLIT1 and SLIT2 which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex. May be required for lung development. Defects in ROBO1 may be a cause of breast and lung cancer. ROBO1 maps within a region of overlapping homozygous deletions characterized in both small cell lung cancer cell lines (SCLC) and in a breast cancer cell line.
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