Polymerase I and Transcript Release Factor (PTRF) (C-Term) Peptide
PTRF
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all PTRF products
- PTRF (Polymerase I and Transcript Release Factor (PTRF))
- Protein Region
- C-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- EESRAERIKR SGLRRVDDFK KAFSKEKMEK TKVRTRENLE KTRLKTKENL
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-PTRF Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- PTRF (Polymerase I and Transcript Release Factor (PTRF))
- Background
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This gene encodes a protein that enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts. This protein regulates rRNA transcription by promoting the dissociation of transcription complexes and the reinitiation of polymerase I on nascent rRNA transcripts. This protein also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins. This protein translocates from caveolae to the cytoplasm after insulin stimulation. Caveolae contain truncated forms of this protein and may be the site of phosphorylation-dependent proteolysis. This protein is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrophy.
Alias Symbols: PTRF, FKSG13,
Protein Size: 390 - Gene ID
- 284119
- NCBI Accession
- NP_036364
- UniProt
- Q6NZI2
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