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Polypyrimidine Tract Binding Protein 1 (PTBP1) (N-Term) Peptide

PTBP1 Reactivity: Human Host: Synthetic WB

Catalog No. ABIN5518181

Quick Overview for Polypyrimidine Tract Binding Protein 1 (PTBP1) (N-Term) Peptide (ABIN5518181)

Target

PTBP1 (Polypyrimidine Tract Binding Protein 1 (PTBP1))

Origin

Human

Source

Synthetic

Application

Western Blotting (WB)

Protein Region

N-Term

Sequence

KFKGDSRSAG VPSRVIHIRK LPIDVTEGEV ISLGLPFGKV TNLLMLKGKN
Polypyrimidine Tract Binding Protein 1 (PTBP1) peptide
PTBP1 Reactivity: Human, Cow, Dog, Mouse, Pig, Rat Host: Synthetic BP, Imm

Polypyrimidine Tract Binding Protein 1 (PTBP1) peptide
PTBP1 Host: Synthetic BP, WB, IHC

Polypyrimidine Tract Binding Protein 1 (PTBP1) peptide
PTBP1 Reactivity: Mammalian Host: Synthetic BP, WB, IHC

Polypyrimidine Tract Binding Protein 1 (PTBP1) (N-Term) peptide
PTBP1 Reactivity: Human Host: Synthetic BP, WB

Polypyrimidine Tract Binding Protein 1 (PTBP1) (Middle Region) peptide
PTBP1 Reactivity: Human Host: Synthetic BP, WB

Polypyrimidine Tract Binding Protein 1 (PTBP1) peptide
PTBP1 Reactivity: Human Host: Synthetic BP, WB

Restrictions

For Research Use only
Format

Lyophilized

Reconstitution

Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.

Storage

-20 °C

Storage Comment

For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
Target

PTBP1 (Polypyrimidine Tract Binding Protein 1 (PTBP1))

Background

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.

Alias Symbols: PTB, PTB2, PTB3, PTB4, pPTB, HNRPI, PTB-1, PTB-T, HNRNPI, HNRNP-I

Protein Size: 167

Gene ID

5725

NCBI Accession

NM_002819, NP_002810

UniProt

P26599

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