Small Nuclear Ribonucleoprotein Polypeptide N (SNRPN) (Middle Region) Peptide
SNRPN
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all SNRPN products
- SNRPN (Small Nuclear Ribonucleoprotein Polypeptide N (SNRPN))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- TASIAGAPTQ YPPGRGTPPP PVGRATPPPG IMAPPPGMRP PMGPPIGLPP
- Characteristics
- This is a synthetic peptide designed for use in combination with anti- SNRPN Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- SNRPN (Small Nuclear Ribonucleoprotein Polypeptide N (SNRPN))
- Background
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This gene is located within the Prader-Willi Syndrome critical region on chromosome 15 and is imprinted and expressed from the paternal allele. It encodes a component of the small nuclear ribonucleoprotein complex, which functions in pre-mRNA processing and may contribute to tissue-specific alternative splicing. Alternative promoter use and alternative splicing result in a multitude of transcript variants encoding the same protein. Transcript variants that initiate at the CpG island-associated imprinting center may be bicistronic and also encode the SNRPN upstream reading frame protein (SNURF) from an upstream open reading frame. In addition, long spliced transcripts for small nucleolar RNA host gene 14 (SNHG14) may originate from the promoters at this locus and share exons with this gene. Alterations in this region are associated with parental imprint switch failure, which may cause Angelman syndrome or Prader-Willi syndrome.
Alias Symbols: SMN, PWCR, SM-D, sm-N, RT-LI, HCERN3, SNRNP-N, SNURF-SNRPN
Protein Size: 240 - Gene ID
- 6638
- NCBI Accession
- NM_003097, NP_003088
- UniProt
- P63162
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