BCL2-Related Protein A1 (BCL2A1) Peptide
BCL2A1
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN973781
Quick Overview for BCL2-Related Protein A1 (BCL2A1) Peptide (ABIN973781)
Target
BCL2A1
(BCL2-Related Protein A1 (BCL2A1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-BCL2A1 antibody (Catalog #: AVARP09047_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- BCL2A1 (BCL2-Related Protein A1 (BCL2A1))
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Background
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BCL2A1s a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and has been shown to be up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival.
Alias Symbols: GRS, BFL1, ACC-1, ACC-2, HBPA1, BCL2L5
Protein Interaction Partner: BAD,BBC3,BID,BIK,HRK,PMAIP1,BAD,BAK1,BAX,BBC3,BCL2L11,BID,BIK,BOK,GRB2,HRK,PMAIP1,BAD,BAX,BCL2L11,BID,BIK,BMF,BOK,Bcl2l11,HRK,PMAIP1
Protein Size: 175 -
Molecular Weight
- 20 kDa
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Gene ID
- 597
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NCBI Accession
- NM_004049, NP_004040
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UniProt
- Q16548
Target
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