Caveolin 1, Caveolae Protein, 22kDa (CAV1) Peptide
CAV1
Reactivity: Human
Host: Synthetic
BP, WB, IHC
Catalog No. ABIN974487
Quick Overview for Caveolin 1, Caveolae Protein, 22kDa (CAV1) Peptide (ABIN974487)
Target
Caveolin-1 (CAV1)
(Caveolin 1, Caveolae Protein, 22kDa (CAV1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-CAV1 antibody (Catalog #: AVARP09019_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Caveolin 1, Caveolae Protein, 22kDa (CAV1) peptide
CAV1 Reactivity: Human, Mouse, Rat, Dog, Pig Host: Synthetic BP, Imm
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Caveolin-1 (CAV1) (Caveolin 1, Caveolae Protein, 22kDa (CAV1))
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Background
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The scaffolding protein is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression.The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by a single transcript from this gene.
Alias Symbols: CAV, MSTP085, VIP21, CGL3, BSCL3
Protein Interaction Partner: ILK,AR,CAV1,CDH1,PPP1CA,PTEN,PTPN1,PTPN11,PTPN6,PTPRF,ABCB1,ADRBK1,AKAP1,APP,AR,BMX,BSG,BST1,BTK,CAV1,CAV2,CD40,CSK,CSNK2A1,CSNK2A2,DNM1,EDNRB,EGFR,ERBB2,ESR1,FLNA,FLOT2,FYN,GJA1,GJA3,GJB2,GNAI2,GRB7,GRK1,GRK5,HRAS,HTR1F,IGFBP3,ILK,INSR,IRS1,KDR,LRP1,MALL,MAPK1,MAPK3,MMP14,NEU3,NGFR,NOS2,NOS3,NTRK1,PDGFRA,PLD1,PLD2,PRNP,PTEN,PTGS2,PTPN1,PTPN11,PTPN6,PTPRF,RAC1,RCVRN,RHOA,S1PR1,SCP2,SOS1,SRC,STOML3,STRN,STRN4,TGFBR1,TNFRSF1B,TRAF2,TRAF6,TRPC1,ADRBK1,APP,AQP3,AR,BMX,BTK,CAV2,CSK,Clic4,DAG1,EDNRB,EGFR,ESR1,FLOT1,FLOT2,GJA1,GJB1,GJB2,GRK1,GRK5,INSR,NEU3,NGFR,NOS2,NOS3,NTRK1,PDGFRA,PDGFRB,PLD2,PRKACA,PTEN,PTGS2,PTPN1,PTPN11,PTPN6,PTPRF,RCVRN,S1PR1,SCP2,SMAD2,SRC,TGFBR1,TNFRSF1B,TRADD,TRAF2,TRPC1,TSC2
Protein Size: 178 -
Molecular Weight
- 20 kDa
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Gene ID
- 857
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NCBI Accession
- NM_001753, NP_001744
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UniProt
- Q03135
Target
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