Cholinergic Receptor, Nicotinic, beta 3 (Neuronal) (CHRNB3) Peptide
CHRNB3
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN974961
Quick Overview for Cholinergic Receptor, Nicotinic, beta 3 (Neuronal) (CHRNB3) Peptide (ABIN974961)
Target
CHRNB3
(Cholinergic Receptor, Nicotinic, beta 3 (Neuronal) (CHRNB3))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-CHRNB3 antibody (Catalog #: AVARP13021_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Cholinergic Receptor, Nicotinic, beta 3 (Neuronal) (CHRNB3) peptide
CHRNB3 Reactivity: Human, Mouse, Rat Host: Synthetic BP, Imm
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- CHRNB3 (Cholinergic Receptor, Nicotinic, beta 3 (Neuronal) (CHRNB3))
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Background
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Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels nAChRs are pentameric structures that are made up of combinations of individual subunits. CHRNB3 is one of the subunits of nAChR. Twelve neuronal nAChR subunits have been described, alpha2-alpha10 and beta2-beta4. CHRNB3 decreased the channel mean open time and burst length. There was also an increase in single channel slope conductance. On the other hand, the calcium permeability and the pharmacological properties of beta3-containing receptors differed little from those of without beta3. Dysfunction of nAChR has been linked to a number of human diseases such as schizophrenia, Alzheimer's and Parkinson's diseases. nAChRs also play a significant role in nicotine addiction.
Protein Size: 458 -
Molecular Weight
- 53 kDa
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Gene ID
- 1142
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NCBI Accession
- NM_000749, NP_000740
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UniProt
- Q05901
Target
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