Nucleoporin 98kDa (NUP98) (N-Term) Peptide
NUP98
Reactivity: Human
Host: Synthetic
BP, WB, ICC
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- Target See all NUP98 products
- NUP98 (Nucleoporin 98kDa (NUP98))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB), Immunocytochemistry (ICC)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-NUP98 antibody (Catalog #: ARP39251_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- NUP98 (Nucleoporin 98kDa (NUP98))
- Background
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The nuclear pore complex (NPC) is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kD nucleoporin is localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kD nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromsome translocatons in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kD nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kD precursor protein. This cleavage results in the 98 kD nucleoporin as well as a 96 kD nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kD nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromsome translocatons in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants, however, not all variants have been fully described.
Alias Symbols: ADIR2, NUP196, NUP96
Protein Interaction Partner: CREBBP,EP300,IPO5,KPNB1,NUP133,NUP62,NUP88,NUP98,NXF1,RAE1,RCC1,SEC13,TNPO1,TPR,CREBBP,CRM1,EP300,KAP104,KPNB1,MOBKL1B,NFX1,NPM1,NUP133,NUP88,NXF1,PARP11,QRICH2,RAE1,Rae1,TNPO1,TNPO2,TPR,USP7
Protein Size: 1800 - Molecular Weight
- 196 kDa
- Gene ID
- 4928
- NCBI Accession
- NM_016320, NP_057404
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