Retinoic Acid Receptor, alpha (RARA) (N-Term) Peptide
RARA
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN982662
Quick Overview for Retinoic Acid Receptor, alpha (RARA) (N-Term) Peptide (ABIN982662)
Target
Retinoic Acid Receptor alpha (RARA)
(Retinoic Acid Receptor, alpha (RARA))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-RARA antibody (Catalog #: ARP40314_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Retinoic Acid Receptor, alpha (RARA) peptide
RARA Reactivity: Human, Mouse, Cow, Dog, Rat Host: Synthetic BP, Imm
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Retinoic Acid Receptor alpha (RARA) (Retinoic Acid Receptor, alpha (RARA))
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Background
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Retinoid signaling is transduced by 2 families of nuclear receptors, retinoic acid receptor (RAR) and retinoid X receptor, which form RXR/RAR heterodimers. In the absence of ligand, DNA-bound RXR/RARA represses transcription by recruiting the corepressors NCOR1, SMRT, and histone deacetylase. When ligand binds to the complex, it induces a conformational change allowing the recruitment of coactivators, histone acetyltransferases, and the basic transcription machinery.
Alias Symbols: NR1B1, RAR
Protein Interaction Partner: NCOR1,NCOR2,ANP32A,BTG1,CDK7,KDM5A,MED6,NCOA1,NCOA2,NCOA3,PARP1,PRMT2,TNFRSF10B,BAG1,BTG1,CCND3,CDK7,CNOT1,COPS2,ESR1,FOXO1,GADD45G,GATA2,IRX4,ITGB1BP2,KAT2B,KDM5A,KLF5,MECR,MED1,MED6,NCOA1,NCOA3,NCOA6,NCOR1,NCOR2,NKX2-1,NPAS2,NR0B2,NR1H2,NR1H3,NR2E3,NRBF2,NRIP1,NRIP2,NSD1,PARP1,PML,PNRC2,POU2F1,PRDX6,PRKCA,RXRA,RXRB,RXRG,SNW1,SP1,SPEN,STAT5B,TADA3,TRIM24,TRIP4,UBE3A,ZBTB16,ARNTL,BAG1,CCND3,CLOCK,GADD45A,GADD45G,Gadd45b,HDAC3,HDAC4,IRX4,JUB,KAT2B,KDM5A,LIMD1,MECR,NCOA2,NCOA6,NCOR1,NCOR2,NKX2-1,NPAS2,NR0B2,NR2E3,NR4A2,NRBF2,NRIP1,Nr0b2,Nsd1,PML,POU2F1,RARA,RXRA,RXRB,RXRG,SKI,SP1,SRC,TADA3,TDG,TRIM24,TRIP4,WTIP,ZBTB16
Protein Size: 457 -
Molecular Weight
- 51 kDa
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Gene ID
- 5914
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NCBI Accession
- NM_001024809, NP_001019980
Target
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