Homolog of Yeast RecQ-mediated Genome Instability 1 (RMI1) (N-Term) Peptide
RMI1
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN983016
Quick Overview for Homolog of Yeast RecQ-mediated Genome Instability 1 (RMI1) (N-Term) Peptide (ABIN983016)
Target
RMI1
(Homolog of Yeast RecQ-mediated Genome Instability 1 (RMI1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-RMI1 antibody (Catalog #: ARP46340_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- RMI1 (Homolog of Yeast RecQ-mediated Genome Instability 1 (RMI1))
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Background
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RMI1 is an essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. RMI1 promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. RMI1 is required for BLM phosphorylation during mitosis. Within the BLM complex, RMI1 is required for BLM and TOP3A stability.RMI1 is a component of protein complexes that limit DNA crossover formation via the dissolution of double Holliday junctions (Raynard et al., 2006 [PubMed 16595695]).[supplied by OMIM]. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-136 BP327553.1 1-136 137-885 DN997105.1 9-757 886-2740 AL732446.4 14777-16631 2741-3508 BC039999.2 2566-3333
Alias Symbols: BLAP75, C9orf76, FLJ12888, RP11-346I8.1
Protein Interaction Partner: FANCA,FANCM,YOL086W-A
Protein Size: 625 -
Molecular Weight
- 70 kDa
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Gene ID
- 80010
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NCBI Accession
- NM_024945, NP_079221
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UniProt
- Q9H9A7
Target
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