Tumor Protein P63 (TP63) (N-Term) Peptide
TP63
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all p63 (TP63) products
- p63 (TP63) (Tumor Protein P63 (TP63))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-TP63 antibody (Catalog #: ARP33998_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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Tumor Protein P63 (TP63) peptide (Ovalbumin)
TP63 Reactivity: Human Host: Synthetic WB, Imm, SDS
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- p63 (TP63) (Tumor Protein P63 (TP63))
- Background
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This protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3), split-hand/foot malformation 4 (SHFM4), ankyloblepharon-ectodermal defects-cleft lip/palate, ADULT syndrome (acro-dermato-ungual-lacrimal-tooth), limb-mammary syndrome, Rap-Hodgkin syndrome (RHS), and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined.
Alias Symbols: B(p51A), B(p51B), EEC3, KET, LMS, OFC8, RHS, SHFM4, TP73L, p51, p63, p73H, p73L, AIS, NBP, p40, TP53L, p53CP, TP53CP
Protein Interaction Partner: FAS,DAXX,EP300,GRB2,HIPK2,HNRNPAB,PPP1R13B,PPP2R5A,TP53,TP63,TP73,WT1,BTRC,GNB2L1,HIPK2,HNRNPAB,SFRS15,UBC,YAP1
Protein Size: 680 - Molecular Weight
- 77 kDa
- Gene ID
- 8626
- NCBI Accession
- NM_003722, NP_003713
- UniProt
- Q9H3D4
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