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Data indicate that high transcription factor ARNTL2 is a top predictor of lung adenocarcinoma patient outcome.
BMAL2 rs7958822 genotype is associated with type 2 diabetes in obese men and women; an interaction between BMAL2 rs7958822 genotype and obesity was observed in men
The prevalence of C carriers in BMAL2 gene rs2306074 T/C in Alzheimer disease patients was significantly higher than that of control subjects
there is significant association between diurnal preference and a polymorphism in PER3 and a novel nominally significant association between diurnal preference and a polymorphism in ARNTL2
ARNTL2 expression is increased in colorectal cancer and in a highly proliferative colon cancer cell line and is related to tumor invasiveness and aggressiveness.
results show a difference in the expression pattern of Bmal2, but not Clock and Dec1 in PD.
Alternative splicing yields novel BMAL2 variants: tissue distribution and functional characterization.
Several new polymorphisms in ARNTL2 are reported.
PER2 is inhibited by BMAL2-CLOCK, which reemphasizes its negative role and a positive role of BMAL2 in circadian transcription
Our results identify Arntl2 as a gene controlling thymocyte apoptosis and proliferation along with Th17 development through the IL-21 pathway.
Our results describe a novel and rather unexpected role for Arntl2 in the immune system that lies outside of its predicted function in circadian rhythm regulation
Results provide additional support for the protective role of the Arntl2 gene located in locus Idd6 in diabetes progression in NOD.C3H congenic mice.
Expression of Bmal2 can rescue the clock and metabolic phenotypes of Bmal1-knockout mice, including rhythmic locomotor activity, rhythmic metabolism, low body weight, and enhanced fat deposition.
These findings demonstrate that (57)Arg in the basic region of DEC2 is essential for its activity in suppressing CLOCK/BMAL2-mediated transactivation.
Arntl2 exhibited a six-fold upregulation in spleens of the NOD.C3H 6.VIII congenic strain compared with the NOD control strain, strain-specific splice variants and a large number of polymorphisms in both coding and non-coding regions.
This gene encodes a basic helix-loop-helix transcription factor belonging to the PAS (PER, ARNT, SIM) superfamily. The PAS proteins play important roles in adaptation to low atmospheric and cellular oxygen levels, exposure to certain environmental pollutants, and diurnal oscillations in light and temperature. This protein forms a transcriptionally active heterodimer with the circadian CLOCK protein, the structurally related MOP4, and hypoxia-inducible factors, such as HIF1alpha. Consistent with its role as a biologically relevant partner of circadian and hypoxia factors, this protein is coexpressed in regions of the brain such as the thalamus, hypothalamus, and amygdala. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
, PAS domain-containing protein 9
, aryl hydrocarbon receptor nuclear translocator-like protein 2
, basic-helix-loop-helix-PAS protein MOP9
, brain and muscle ARNT-like 2
, class E basic helix-loop-helix protein 6
, member of PAS protein 9
, transcription factor BMAL2
, brain-muscle-ARNT-like protein 2
, brain and muscle Arnt-like protein 2 variant d
, aryl hydrocarbon receptor nuclear translocator-like 2
, aryl hydrocarbon receptor nuclear translocator-like protein 2-like