RFWD2 Proteins

5 Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2) Proteins from 3 manufacturers are available on www.antibodies-online.com.

Data Quality
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Type
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    Protein
Antigen
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Reactivity
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Application
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Host
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Binding Specificity
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Conjugate
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Protein Type
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Format
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5 Products
Recombinant Protein, Insect Cells (Source), Purity >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
ReactivityHuman
Application Crys, ELISA, SDS, WB
Order details Cat. No. ABIN3095004
$13,376.85
Plus shipping costs $45.00 and $22.00 dry ice
Will be delivered in 70 Business Days
Recombinant Protein, Insect Cells (Source), Purity >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
ReactivityMouse (Murine)
Application Crys, ELISA, SDS, WB
Order details Cat. No. ABIN3137447
$13,376.85
Plus shipping costs $45.00 and $22.00 dry ice
Will be delivered in 70 Business Days
ReactivityHuman
Application AP, AA, ELISA, WB
Order details Cat. No. ABIN1317872
$414.29
Plus shipping costs $45.00 and $22.00 dry ice
Delivery in 11 to 12 Business Days
Recombinant Protein, HEK-293 Cells (Source), Purity > 80 % as determined by SDS-PAGE and Coomassie blue staining
ReactivityHuman
Application AbP, Func, PI, STD
Order details Cat. No. ABIN2730791
$888.80
20 μg
Plus shipping costs $45.00 and $22.00 dry ice
Will be delivered in 11 Business Days
Recombinant Protein, HEK-293 Cells (Source), Purity > 80 % as determined by SDS-PAGE and Coomassie blue staining
ReactivityHuman
Application AbP, Func, PI, STD
Order details Cat. No. ABIN2730790
$932.80
20 μg
Plus shipping costs $45.00 and $22.00 dry ice
Will be delivered in 11 Business Days
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RFWD2 Protein Profile

Protein Summary

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1 (By similarity).

Alternative names and synonyms associated with RFWD2

  • ring finger and WD repeat domain 2 (RFWD2) antibody
  • ring finger and WD repeat domain 2 (Rfwd2) antibody
  • ring finger and WD repeat domain 2, E3 ubiquitin protein ligase (rfwd2) antibody
  • ring finger and WD repeat domain 2, E3 ubiquitin protein ligase L homeolog (rfwd2.L) antibody
  • ring finger and WD repeat domain 2 (rfwd2) antibody
  • AI316802 antibody
  • C80879 antibody
  • cop1 antibody
  • RFWD2 antibody
  • RGD1304773 antibody
  • rnf200 antibody
  • zgc:163067 antibody

Protein level used designations for RFWD2

E3 ubiquitin-protein ligase RFWD2 , RING finger and WD repeat domain protein 2 , RING finger protein 200 , constitutive photomorphogenesis protein 1 homolog , constitutive photomorphogenic protein (COP1) , hCOP1 , putative ubiquitin ligase COP1 , constitutive photomorphogenic protein 1 , mCOP1 , ring finger and WD repeat domain 2 , rp11-318c24.3

GENE ID SPECIES
64326 Homo sapiens
26374 Mus musculus
360860 Rattus norvegicus
429072 Gallus gallus
457541 Pan troglodytes
480060 Canis lupus familiaris
519896 Bos taurus
548953 Xenopus (Silurana) tropicalis
100158422 Xenopus laevis
100021432 Monodelphis domestica
100553769 Anolis carolinensis
100582328 Nomascus leucogenys
100728351 Cavia porcellus
100037391 Danio rerio
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