Browse our WNK2 Proteins (WNK2)

Full name:: WNK Lysine Deficient Protein Kinase 2 Proteins (WNK2)

On www.antibodies-online.com are 4 WNK Lysine Deficient Protein Kinase 2 (WNK2) Proteins from 3 different suppliers available. Additionally we are shipping WNK2 Antibodies (40) and and many more products for this protein. A total of 48 WNK2 products are currently listed.

Synonyms:: 1810073P09Rik, ARABIDOPSIS THALIANA WITH NO K 2, ATWNK2, AW122246, ESTM15, mKIAA1760, NY-CO-43, P/OKcl.13, PRKWNK2, PROTEIN KINASE, RGD1307284, SDCCAG43, with no lysine (K) kinase 2, WNK2, X83337, ZIK3

list all proteins	Gene Name	GeneID	UniProt
	WNK2	65268	Q9Y3S1
Mouse WNK2	WNK2	75607	Q3UH66
Rat WNK2	WNK2	306811
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Human WNK Lysine Deficient Protein Kinase 2 (WNK2) interaction partners

WNK2 promoter methylation and silencing in gliomas is associated with increased JNK activation and MMP2 expression and activity, thus explaining in part tumor cell invasion potential.
Downregulation of WNK2 by promoter hypermethylation occurs early in Pancreatic ductal adenocarcinoma pathogenesis and may support tumor cell growth via the ERK-MAPK pathway.
Wnk kinases are positive regulators of canonical Wnt/beta-catenin signaling.
results validate the WNK2 gene as a recurrent target for epigenetic silencing in glia-derived brain tumours and provide first mechanistic evidence for a tumour-suppressing role of WNK2 that is related to Rac1 signalling and tumour cell invasion and growth
a role for WNK2 in the regulation of CCCs in the mammalian brain, with implications for both cell volume regulation and/or GABAergic signaling.
epigenetic silencing, occasional deletion and point mutation, and functional assessment suggest that aberrations of WNK2 may contribute to unregulated tumor cell growth
WNK2 is involved in the modulation of growth factor-induced cancer cell proliferation through the MEK1/ERK1/2 pathway.
WNK2 controls a RhoA-mediated cross-talk mechanism that regulates the efficiency with which MEK1 can activate ERK1/2 upon growth factor stimulation.
Epigenetic silencing of the kinase tumor suppressor WNK2 is tumor-type and tumor-grade specific.

WNK2 Protein Profile

Protein Summary

The protein encoded by this gene is a cytoplasmic serine-threonine kinase that contains cysteine in place of the lysine found at the conserved ATP-binding location in subdomain II of protein kinases. Since this protein does have kinase activity, it is possible that another lysine in the kinase subdomain I can substitute for the missing conserved lysine.

Alternative names and synonyms associated with WNK2

WNK lysine deficient protein kinase 2 (WNK2)
with no lysine (K) kinase 2 (WNK2)
WNK lysine deficient protein kinase 2 (Wnk2)

1810073P09Rik protein
ARABIDOPSIS THALIANA WITH NO K 2 protein
ATWNK2 protein
AW122246 protein
ESTM15 protein
mKIAA1760 protein
NY-CO-43 protein
P/OKcl.13 protein
PRKWNK2 protein
PROTEIN KINASE protein
RGD1307284 protein
SDCCAG43 protein
with no lysine (K) kinase 2 protein
WNK2 protein
X83337 protein
ZIK3 protein

Protein level used designations for WNK2

WNK lysine deficient protein kinase 2 , antigen NY-CO-43 , mitogen-activated protein kinase kinase kinase , protein kinase lysine-deficient 2 , protein kinase with no lysine 2 , protein kinase, lysine deficient 2 , serine/threonine-protein kinase WNK2 , serologically defined colon cancer antigen 43 , kinase deficient protein

GENE ID	SPECIES
415984	Gallus gallus
506520	Bos taurus
717275	Macaca mulatta
100544669	Meleagris gallopavo
821810	Arabidopsis thaliana
65268	Homo sapiens
75607	Mus musculus
306811	Rattus norvegicus

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