Browse our anti-AKT (AKT1) Antibodies

Human V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) interaction partners

1. Circ-CFH (show CFH Antibodies) promotes glioma progression by sponging miR (show MLXIP Antibodies)-149 and regulating the AKT1 signaling pathway.

2. High AKT1 expression is associated with metastasis via epithelialmesenchymal transition carcinoma in colorectal cancer.

3. High AKT1 expression is associated with tumor-node-metastasis in nonsmall cell lung cancer.

4. High expression of AKT1 is associated with drug resistance and proliferation of breast cancer.

5. Germline variants in AKT1 gene are associated with prostate cancer.

6. High AKT1 expression is associated with cisplatinresistant oral cancer.

7. that Akt1 was a novel target for miR (show MLXIP Antibodies)-637, and its knockdown also induced cell growth inhibition and apoptosis in pancreatic ductal adenocarcinoma cells

8. High AKT1 expression is associated with periodontitis.

9. High AKT1 expression is associated with angiogenesis of esophageal squamous cell carcinoma.

10. High AKT1 expression is associated with Pancreatic Ductal Adenocarcinoma Metastasis.

Mouse (Murine) V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) interaction partners

1. M-CSF (show CSF1R Antibodies)-evoked ERK1/2 activation was decreased, whereas AKT activation was enhanced in SHP2 (show PTPN11 Antibodies)-deficient BMMs. ERK1/2, via its downstream target RSK2 (show RPS6KA3 Antibodies), mediates this negative feedback by negatively regulating phosphorylation of M-CSF (show CSF1R Antibodies) receptor at Tyr721 and, consequently, its binding to p85 (show ECM1 Antibodies) subunit of PI3K and PI3K activation.

2. Site-directed mutagenesis of Akt at Cys224 revealed that S-nitrosylation at this site was pivotal for the reduced phosphorylation at Akt Ser473, which led to impaired Akt signaling. Furthermore, on HHcy challenge, as compared with GSNOR (show ADH5 Antibodies)(+/+)ApoE (show APOE Antibodies)(-/-) littermate controls, GSNOR (show ADH5 Antibodies)(-/-)ApoE (show APOE Antibodies)(-/-) double knockout mice showed reduced T-cell activation with concurrent reduction of atherosclerosis.

3. the present study suggested that Pulsed electromagnetic fields (PEMFs) reduced osteoclast formation from RAW264.7 macrophages via inhibition of the Akt/mTOR (show FRAP1 Antibodies) signaling pathway. These findings provided novel insight into the mechanisms through which PEMFs suppress osteoclast differentiation.

4. findings uncover a new function of p53 (show TP53 Antibodies) in the regulation of Akt signaling and reveal how p53 (show TP53 Antibodies), ASS1 (show ASS1 Antibodies), and Akt are interrelated to each other.

5. Here, we describe a role for PI3K/AKT in the regulation of TRF1 (show TERF1 Antibodies), an essential component of the shelterin complex. PI3K and AKT chemical inhibitors reduce TRF1 (show TERF1 Antibodies) telomeric foci and lead to increased telomeric DNA damage and fragility. TRF1 (show TERF1 Antibodies) is phosphorylated by AKT regulating TRF1 (show TERF1 Antibodies) protein stability and TRF1 (show TERF1 Antibodies) binding to telomeric DNA in vitro and are important for in vivo TRF1 (show TERF1 Antibodies) telomere location and cell viability.

6. High AKT1 expression is associated with cardiac hypertrophy.

7. CTRP1 protected against Dox-induced cardiotoxicity via activation of AKT

8. Noise exposure led to enhanced JNK (show MAPK8 Antibodies) phosphorylation and IRS1 (show IRS1 Antibodies) serine phosphorylation as well as reduced Akt phosphorylation in skeletal muscles in response to exogenous insulin (show INS Antibodies) stimulation.

9. WT PDCD5 (show PDCD5 Antibodies) competitively inhibited interaction between histone deacetylase 3 (HDAC3 (show HDAC3 Antibodies)) and AKT, but PDCD5 (show PDCD5 Antibodies)(L6R), an HDAC3 (show HDAC3 Antibodies)-binding-deficient mutant, did not. Knockdown of PDCD5 (show PDCD5 Antibodies) accelerated HDAC3 (show HDAC3 Antibodies)-AKT interaction, AKT and eNOS (show NOS3 Antibodies) phosphorylation, and nitric oxide (NO) production

10. both NAD and NADH significantly increased the intracellular ATP levels of BV2 (show DNAH9 Antibodies) microglia, which were attenuated by SIRT2 (show SIRT2 Antibodies) siRNA, the SIRT2 (show SIRT2 Antibodies) inhibitor AGK2 (show GUK1 Antibodies), and the phosphatidylinositol 3-kinase/Akt inhibitor LY294002. Results suggested that SIRT2 (show SIRT2 Antibodies) mediates the NAD-induced and NADH-induced increase in Akt phosphorylation in BV2 (show DNAH9 Antibodies) microglia.

Fruit Fly (Drosophila melanogaster) V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) interaction partners

1. The metabolic defects of cycG (show CCNG1 Antibodies) mutant animals are abrogated by a concomitant loss of Wdb, CycG (show CCNG1 Antibodies) presumably influences Akt1 activity at the PP2A (show PPP2R2B Antibodies) nexus; Well rounded (Wrd), another B' subunit of PP2A (show PPP2R2B Antibodies) in Drosophila, binds CycG (show CCNG1 Antibodies) similar to Wdb, and that its loss ameliorates some, but not all, of the metabolic defects of cycG (show CCNG1 Antibodies) mutants.

2. Our findings demonstrated that lovastatin restored LRRK2-G2019S neurite degeneration by augmenting Akt/NRF2 pathway and inhibiting downstream GSK3b activity, which decreased phospho-tau levels. We suggested that lovastatin is a potential disease-modifying agent for LRRK2-G2019S parkinsonism.

3. subtle manipulation of foxo (show FOXO Antibodies) through Akt1 can enhance survival during adverse nutrient conditions in Drosophila.

4. The developmental delay of these novel Akt1 hypomorphs results in a latent phenotype uncovered by generation of somatic clones

5. these data show that Drosophila Trbl has a conserved role to bind Akt and block Akt-mediated insulin signaling, and implicate Trib proteins as novel sites of signaling pathway integration that link nutrient availability with cell growth and proliferation

6. AKT1 and caspase-dependent regulation of Acn stability adjusts basal autophagy levels.

7. Akt1 governs two critical elements of synapse development, neurotransmitter receptor (show GRIN1 Antibodies) localization, and postsynaptic membrane elaboration

8. Tsc2 (show TSC2 Antibodies) mutants showed a dramatic decrease in the levels of phosphorylated Akt, and interestingly, Akt mutants phenocopied Tsc2 (show TSC2 Antibodies) mutants, leading to the hypothesis that Tsc2 (show TSC2 Antibodies) and Akt might work via the same genetic pathway to regulate synapse growth.

9. Hippo signaling not only blocks cell division and promotes apoptosis, but also regulates cellular growth by inhibiting the Akt pathway activity.

10. Regeneration of Drosophila sensory neuron axons and dendrites is regulated by the Akt pathway involving Pten and microRNA bantam.

Cow (Bovine) V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) interaction partners

1. Thus, activation of STAT3 (show STAT3 Antibodies) and inactivation of AKT signaling are involved in structural regression of the corpus luteum.

2. the measurement of levels of PI3K-Akt pathway components in FCs from ovarian follicles carrying oocytes with distinct developmental competences is a useful tool to identify putative molecular pathways involved in the acquisition of oocyte competence.

3. These results demonstrate that activation of AKT is required for gonadotropin regulation of CTNNB1 (show CTNNB1 Antibodies) accumulation and subsequent ovarian E2 production.

4. Caveolin-1 (show CAV1 Antibodies) scaffolding domain residue phenylalanine 92 modulates Akt signaling

5. TG2 (show TGM2 Antibodies) contributes to 5-hydroxytryptamine-induced distal pulmonary artery smooth muscle cell proliferation via promotion of AKT signaling, likely via its serotonylation.

6. results suggest that PI3K-Akt activity is important for the internalization of S. aureus and phosphorylation of GSK-3alpha, GSK-3beta, and NF-kappaB (show NFKB1 Antibodies).

7. The current study was designed to determine mechanisms underlying 20-hydroxyeicosatetraenoic acid -stimulated nitric oxide (NO) release, and particularly the role of NADPH oxidase (show NOX1 Antibodies), reactive oxygen species, and PI3-kinase (show PIK3CA Antibodies) in stimulated NO release.

8. PI3K/Akt and p53 (show TP53 Antibodies) are redox-regulated in bovine aortic endothelial cells exposed to hydrogen peroxide

9. Thus our data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR, p70S6K, and ERK1/2.

10. Gab1 tyrosine phosphorylation is stimulated by flow shear stress to mediate protein kinase B and endothelial nitric-oxide synthase (show NOS3 Antibodies) activation in endothelial cells

Xenopus laevis V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) interaction partners

1. These findings highlight novel and essential roles of PFKFB4 (show PFKFB4 Antibodies) activity in later stages of neural crest (NC) development that are wired into the NC gene regulatory network.

Pig (Porcine) V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) interaction partners

1. Studied the effects of microRNA-27a on myogenin (show MYOG Antibodies) expression and the Akt/FoxO1 (show FOXO1 Antibodies) signal pathway during porcine myoblast differentiation. Overexpression of miR (show MYLIP Antibodies)-27a suppressed myogenin (show MYOG Antibodies) expression during porcine myoblast differentiation, whereas inhibition of miR (show MYLIP Antibodies)-27a promoted the mRNA and protein expression levels of myogenin (show MYOG Antibodies); overexpression of miR (show MYLIP Antibodies)-27a decreased the level of P-Akt/Akt and increased the protein level of FoxO1 (show FOXO1 Antibodies).

2. SCF (show KITLG Antibodies) is a critical regulatory factor for conceptus development and implantation during pregnancy in pigs.

3. These results indicate glycine enhances muscle protein mass under an inflammatory condition. The beneficial roles of glycine on the muscle are closely associated with maintaining Akt-mTOR (show FRAP1 Antibodies)-FOXO1 (show FOXO1 Antibodies) signaling and suppressing the activation of TLR4 (show TLR4 Antibodies) and/or NOD2 (show NOD2 Antibodies) signaling pathways.

4. Data show that homocysteine (Hcy) can ameliorate the endothelium-independent hypoxic coronary vasoconstriction, in which the inhibition of PI3K/Akt signaling pathway may be involved.

5. In pigs, lactose synthesis was significantly elevated with the increase of milk production and AKT1 could positively regulate lactose synthesis.

6. In conclusion, our observations reveal that PRRSV triggers the activation of FAK (show PTK2 Antibodies)-PI3K-AKT-Rac1 (show RAC1 Antibodies) signaling pathway to facilitate its entry into cells.

7. Host PI3K and Akt1 play a role in viral gene expression, leading to an increase in porcine reproductive and respiratory syndrome virus replication.

8. Activity of AKT is not essential for induction of germinal vesicle breakdown in porcine oocytes but plays a substantial role during progression of meiosis to MI/MII-stage.

9. IL-4 induced activation of Akt/SREBP-1/lipid biosynthesis in EC, resulting in protection against membrane attack complex and melittin, in association with mitochondrial protection.

10. findings show that megalin (show LRP2 Antibodies) is the sensor that determines whether cells will be protected or injured by albumin (show ALB Antibodies); it binds protein kinase B (PKB) in a D-3-phosphorylated phospholipid-insensitive manner, anchoring PKB in the luminal plasma membrane [

Arabidopsis thaliana V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) interaction partners

1. CIPK23 and AtKC1 exhibit distinct effects; however, they act synergistically and balance K(+) uptake/leakage to modulate AKT1-mediated low potassium responses in Arabidopsis.

2. results suggest that NO decreases K(+) absorption by promoting the synthesis of vitamin B6 PLP (show FNTA Antibodies), which further represses the activity of K(+) channel (show KCNC4 Antibodies) AKT1 in Arabidopsis.

3. Examination of the athak5 atakt1 double mutant, revealing novel aspects of an uptake system as yet unidentified by genetic means.

4. AKT1 is regulated by CIPK23 in guard cells and is involved in water stress responses.

5. These findings provide further insights into the signaling network consisting of CBL (show CBL Antibodies)-CIPK-PP2C interactions in the activation of the AKT1 channel.

6. Electrophysiological results showed that AtKC1 inhibited the AKT1-mediated inward K(+) currents and negatively shifted the voltage dependence of AKT1 channels.

7. AtHAK5 and AKT1 are vital for plant growth and development at low K+ concentrations.

8. In the range between 0.01 and 0.05 mM K+ AtHAK5 and AtAKT1 are the only contributors to K+ acquisition. At higher K+ concentrations, unknown systems come into operation and participate together with AtAKT1 in low-affinity K+ uptake.

9. CIPK23 directly phosphorylates the K+ transporter AKT1

10. Data show that interacting calcium sensors (CBL1 and CBL9) together with CIPK23, but not either alone, activated the AKT1 channel in a Ca(2 (show CA2 Antibodies)+)-dependent manner, connecting the Ca(2 (show CA2 Antibodies)+) signal to K(+) uptake through activation of a K(+) channel (show KCNC4 Antibodies).

Caenorhabditis elegans (C. elegans) V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) interaction partners

1. the LIN-28/let-7/AKT/DAF-16 axis is a program that plays an important role in balancing reproduction and somatic maintenance.

2. this study shows that akt-1 and akt-2 negatively regulate DNA-damage-induced apoptosis in the C. elegans germline and the antiapoptotic activity of akt-1 is independent of its target gene daf-16 but dependent on cep-1/p53 (show TP53 Antibodies).

3. Modulation of pptr-1 affects insulin (show INS Antibodies)/IGF-1 (show IGF1 Antibodies) signaling pathway-associated phenotypes including life span, dauer, stress resistance, and fat storage; study shows that PPTR-1 functions by regulating worm AKT-1 phosphorylation at Thr (show TRH Antibodies) 350.

Goat V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) interaction partners

1. Exogenous AKT was transcribed, and AKT was overexpressed, inducing the phosphorylation of p70S6K (show RPS6KB1 Antibodies) (Thr389) and 4E-BP1 (show EIF4EBP1 Antibodies) (Thr37/46) in goat fetal fibroblasts.

Guinea Pig V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) interaction partners

1. findings suggested that the expressions of the cardiac CACNA1C (show CACNA1C Antibodies) were under the CLOCK-BMAL1 (show ARNTL Antibodies) regulation, probably through the PI3K-Akt signal pathway

Zebrafish V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) interaction partners

1. This study has identified Akt as a novel intracellular pathway required for neural crest differentiation.

2. Overexpression of human Akt1 enhances adipogenesis and leads to lipoma formation in zebrafish.