Browse our anti-AKT (AKT1) Antibodies

Human V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) interaction partners

1. TMCO1 (show TMCO1 Antibodies) recruited the PH domain and leucine-rich repeat protein phosphatase 2 (PHLPP2 (show PHLPP2 Antibodies)) to dephosphorylate pAKT1(serine 473) (S473). Mutagenesis at S60 of the TMCO1 (show TMCO1 Antibodies) protein released TMCO1 (show TMCO1 Antibodies)-induced cell-cycle arrest and restored the AKT pathway in BFTC905 cells. Stable TMCO1 (show TMCO1 Antibodies) (wild-type) overexpression suppressed, whereas T33A and S60A mutants recovered, tumor size in xenograft mice.

2. AKT inhibition led to decreased FMRP (show FMR1 Antibodies) levels, as expected due to the known FMR1/FMRP (show FMR1 Antibodies) negative feedback loop. But rFSH and the mTOR (show FRAP1 Antibodies) inhibition increased them, indicating a decoupling of this FMR1/FMRP (show FMR1 Antibodies) negative feedback loop in our model system

3. Combined targeting of AKT and SRC (show SRC Antibodies) resulted in a synergistic efficacy against human pancreatic cancer growth and metastasis

4. IGF-1R (show IGF1R Antibodies) and AKT inhibitors further increased apoptosis by Nutlin-3a in parental MHM cells and the cisplatin-resistant clones, confirming IGF-1R (show IGF1R Antibodies)/AKT signaling promotes apoptosis resistance.

5. The results of the present study revealed a correlation between BAFF (show TNFSF13B Antibodies) and the PI3K (show PIK3CA Antibodies)/Akt/mTOR (show FRAP1 Antibodies) signaling pathway, and it is hypothesized that they are involved in the pathogenesis of lupus nephritis

6. results reveal how alterations in FBXO31 (show FBXO5 Antibodies) phosphorylation, mediated by AKT and ATM (show ATM Antibodies), underlie physiological regulation of FBXO31 (show FBXO5 Antibodies) levels in unstressed and genotoxically stressed cells

7. By monitoring single-cell dynamics in each of these contexts, the authors identified PI3K (show PIK3CA Antibodies)/Akt regulation of glycolysis as a multifaceted modulator of single-cell metabolic dynamics that is required to maintain metabolic stability in proliferating cells.

8. Mycobacterial trehalose 6,6'-dimycolate modulates transendothelial migration of neutrophils upon mycobacterial infection through prolonged AKT phosphorylation.

9. High AKT1 expression is associated with non-small cell lung cancer metastasis.

10. Knockdown of MTDH (show MTDH Antibodies) expression also upregulated PTEN and suppressed pAKT protein expression in Caki2 cells. In conclusion, the present study is the first, to the best of our knowledge, to provide evidence suggesting that miRNA30a5p suppresses tumor human renal cancer cell proliferation via the MTDH (show MTDH Antibodies)/PTEN/AKT pathway

Mouse (Murine) V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) interaction partners

1. CYP2E1 (show CYP2E1 Antibodies)-induced oxidative stress may be responsible for ethanol-induced suppression of Akt phosphorylation and pharmacological modulation of Akt in liver may be an effective strategy for the treatment of ethanol-induced fatty liver.

2. The authors find in Mus (show TRPV6 Antibodies) musculus, each AKT isoform has a unique expression pattern in the hippocampus. AKT1, but not AKT2 (show AKT2 Antibodies) or AKT3 (show AKT3 Antibodies), is required for late long term potetiation (LTD) through regulating activity-induced protein synthesis. Interestingly, AKT activity inhibits mGluR (show GRM8 Antibodies)-LTD, with overlapping functions for AKT1 and AKT3 (show AKT3 Antibodies).

3. At 3days after the first tamoxifen injection, Akt1(-/-)/iAkt2 KO hearts showed decreased expression of connexin43 (Cx43 (show GJA1 Antibodies)) and connexin-interacting protein zonula occludens-1 (ZO-1 (show TJP1 Antibodies)). Furthermore, Akt1/2 silencing significantly decreased both Cx43 (show GJA1 Antibodies) and ZO-1 (show TJP1 Antibodies) expression

4. AKT1 plays an important role in the underlying pathomechanism.

5. Findings suggest that Akt1 deficiency modulates GABAergic interneurons and GABA A receptor expression, contributing to hippocampus-dependent cognitive functional impairment.

6. Saliva (show RAG1AP1 Antibodies)-induced enhancement of Akt pathway activation was observed in tick-borne encephalitis virus-infected dendritic cells.

7. FSTL1 (show FSTL1 Antibodies) may exert its actions through the modulation of Akt signaling.

8. Building upon previous work suggesting that FAK (show PTK2 Antibodies)-Akt1 binding is mediated by the FAK (show PTK2 Antibodies) F1 lobe, we demonstrated that independently expressing the F1 domain in human Caco-2 or murine CT-26 (show DDX53 Antibodies) colon cancer cells by transient or stable inducible plasmid expression respectively prevents the stimulation of cancer cell adhesion by increased extracellular pressure.

9. Findings suggest an important role for effector-like memory CD8 (show CD8A Antibodies)(+) T cells in tumor immune surveillance and indicate proto-oncogene (show RAB1A Antibodies) proteins c-akt (Akt) as a key signaling node in the development of protective memory CD8 (show CD8A Antibodies)(+) T-cell responses.

10. data showed that Klotho (show KL Antibodies) protects Tac (show IL2RA Antibodies)-induced oxidative stress by negatively regulating the PI3K/AKT pathway and subsequently enhancing FoxO3a (show FOXO3 Antibodies)-mediated MnSOD (show SOD2 Antibodies) expression.

Fruit Fly (Drosophila melanogaster) V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) interaction partners

1. The metabolic defects of cycG (show CCNG1 Antibodies) mutant animals are abrogated by a concomitant loss of Wdb, CycG (show CCNG1 Antibodies) presumably influences Akt1 activity at the PP2A (show PPP2R2B Antibodies) nexus; Well rounded (Wrd), another B' subunit of PP2A (show PPP2R2B Antibodies) in Drosophila, binds CycG (show CCNG1 Antibodies) similar to Wdb, and that its loss ameliorates some, but not all, of the metabolic defects of cycG (show CCNG1 Antibodies) mutants.

2. Our findings demonstrated that lovastatin restored LRRK2-G2019S neurite degeneration by augmenting Akt/NRF2 pathway and inhibiting downstream GSK3b activity, which decreased phospho-tau levels. We suggested that lovastatin is a potential disease-modifying agent for LRRK2-G2019S parkinsonism.

3. subtle manipulation of foxo (show FOXO Antibodies) through Akt1 can enhance survival during adverse nutrient conditions in Drosophila.

4. The developmental delay of these novel Akt1 hypomorphs results in a latent phenotype uncovered by generation of somatic clones

5. these data show that Drosophila Trbl has a conserved role to bind Akt and block Akt-mediated insulin signaling, and implicate Trib proteins as novel sites of signaling pathway integration that link nutrient availability with cell growth and proliferation

6. AKT1 and caspase-dependent regulation of Acn stability adjusts basal autophagy levels.

7. Akt1 governs two critical elements of synapse development, neurotransmitter receptor (show GRIN1 Antibodies) localization, and postsynaptic membrane elaboration

8. Tsc2 (show TSC2 Antibodies) mutants showed a dramatic decrease in the levels of phosphorylated Akt, and interestingly, Akt mutants phenocopied Tsc2 (show TSC2 Antibodies) mutants, leading to the hypothesis that Tsc2 (show TSC2 Antibodies) and Akt might work via the same genetic pathway to regulate synapse growth.

9. Hippo signaling not only blocks cell division and promotes apoptosis, but also regulates cellular growth by inhibiting the Akt pathway activity.

10. Regeneration of Drosophila sensory neuron axons and dendrites is regulated by the Akt pathway involving Pten and microRNA bantam.

Cow (Bovine) V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) interaction partners

1. Thus, activation of STAT3 (show STAT3 Antibodies) and inactivation of AKT signaling are involved in structural regression of the corpus luteum.

2. the measurement of levels of PI3K-Akt pathway components in FCs from ovarian follicles carrying oocytes with distinct developmental competences is a useful tool to identify putative molecular pathways involved in the acquisition of oocyte competence.

3. These results demonstrate that activation of AKT is required for gonadotropin regulation of CTNNB1 (show CTNNB1 Antibodies) accumulation and subsequent ovarian E2 production.

4. Caveolin-1 (show CAV1 Antibodies) scaffolding domain residue phenylalanine 92 modulates Akt signaling

5. TG2 (show TGM2 Antibodies) contributes to 5-hydroxytryptamine-induced distal pulmonary artery smooth muscle cell proliferation via promotion of AKT signaling, likely via its serotonylation.

6. results suggest that PI3K-Akt activity is important for the internalization of S. aureus and phosphorylation of GSK-3alpha, GSK-3beta, and NF-kappaB (show NFKB1 Antibodies).

7. The current study was designed to determine mechanisms underlying 20-hydroxyeicosatetraenoic acid -stimulated nitric oxide (NO) release, and particularly the role of NADPH oxidase (show NOX1 Antibodies), reactive oxygen species, and PI3-kinase (show PIK3CA Antibodies) in stimulated NO release.

8. PI3K/Akt and p53 (show TP53 Antibodies) are redox-regulated in bovine aortic endothelial cells exposed to hydrogen peroxide

9. Thus our data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR, p70S6K, and ERK1/2.

10. Gab1 tyrosine phosphorylation is stimulated by flow shear stress to mediate protein kinase B and endothelial nitric-oxide synthase (show NOS3 Antibodies) activation in endothelial cells

Xenopus laevis V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) interaction partners

1. These findings highlight novel and essential roles of PFKFB4 (show PFKFB4 Antibodies) activity in later stages of neural crest (NC) development that are wired into the NC gene regulatory network.

Pig (Porcine) V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) interaction partners

1. SCF (show KITLG Antibodies) is a critical regulatory factor for conceptus development and implantation during pregnancy in pigs.

2. These results indicate glycine enhances muscle protein mass under an inflammatory condition. The beneficial roles of glycine on the muscle are closely associated with maintaining Akt-mTOR (show FRAP1 Antibodies)-FOXO1 (show FOXO1 Antibodies) signaling and suppressing the activation of TLR4 (show TLR4 Antibodies) and/or NOD2 (show NOD2 Antibodies) signaling pathways.

3. Data show that homocysteine (Hcy) can ameliorate the endothelium-independent hypoxic coronary vasoconstriction, in which the inhibition of PI3K/Akt signaling pathway may be involved.

4. In pigs, lactose synthesis was significantly elevated with the increase of milk production and AKT1 could positively regulate lactose synthesis.

5. In conclusion, our observations reveal that PRRSV triggers the activation of FAK-PI3K-AKT-Rac1 signaling pathway to facilitate its entry into cells.

6. Host PI3K and Akt1 play a role in viral gene expression, leading to an increase in porcine reproductive and respiratory syndrome virus replication.

7. Activity of AKT is not essential for induction of germinal vesicle breakdown in porcine oocytes but plays a substantial role during progression of meiosis to MI/MII-stage.

8. IL-4 induced activation of Akt/SREBP-1/lipid biosynthesis in EC, resulting in protection against membrane attack complex and melittin, in association with mitochondrial protection.

9. findings show that megalin (show LRP2 Antibodies) is the sensor that determines whether cells will be protected or injured by albumin (show ALB Antibodies); it binds protein kinase B (PKB) in a D-3-phosphorylated phospholipid-insensitive manner, anchoring PKB in the luminal plasma membrane [

10. protein kinase B (PKB/Akt)was localized in the granulosa cells of primordial follicles and in the basal layers of the granulosa cells of preantral and antral follicles, but were not localized in atretic follicles and corpora lutea

Arabidopsis thaliana V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) interaction partners

1. CIPK23 and AtKC1 exhibit distinct effects; however, they act synergistically and balance K(+) uptake/leakage to modulate AKT1-mediated low potassium responses in Arabidopsis.

2. results suggest that NO decreases K(+) absorption by promoting the synthesis of vitamin B6 PLP (show FNTA Antibodies), which further represses the activity of K(+) channel (show KCNC4 Antibodies) AKT1 in Arabidopsis.

3. Examination of the athak5 atakt1 double mutant, revealing novel aspects of an uptake system as yet unidentified by genetic means.

4. AKT1 is regulated by CIPK23 in guard cells and is involved in water stress responses.

5. These findings provide further insights into the signaling network consisting of CBL (show CBL Antibodies)-CIPK-PP2C interactions in the activation of the AKT1 channel.

6. Electrophysiological results showed that AtKC1 inhibited the AKT1-mediated inward K(+) currents and negatively shifted the voltage dependence of AKT1 channels.

7. AtHAK5 and AKT1 are vital for plant growth and development at low K+ concentrations.

8. In the range between 0.01 and 0.05 mM K+ AtHAK5 and AtAKT1 are the only contributors to K+ acquisition. At higher K+ concentrations, unknown systems come into operation and participate together with AtAKT1 in low-affinity K+ uptake.

9. CIPK23 directly phosphorylates the K+ transporter AKT1

10. Data show that interacting calcium sensors (CBL1 and CBL9) together with CIPK23, but not either alone, activated the AKT1 channel in a Ca(2 (show CA2 Antibodies)+)-dependent manner, connecting the Ca(2 (show CA2 Antibodies)+) signal to K(+) uptake through activation of a K(+) channel (show KCNC4 Antibodies).

Caenorhabditis elegans (C. elegans) V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) interaction partners

1. the LIN-28/let-7/AKT/DAF-16 axis is a program that plays an important role in balancing reproduction and somatic maintenance.

2. this study shows that akt-1 and akt-2 negatively regulate DNA-damage-induced apoptosis in the C. elegans germline and the antiapoptotic activity of akt-1 is independent of its target gene daf-16 but dependent on cep-1/p53 (show TP53 Antibodies).

3. Modulation of pptr-1 affects insulin (show INS Antibodies)/IGF-1 (show IGF1 Antibodies) signaling pathway-associated phenotypes including life span, dauer, stress resistance, and fat storage; study shows that PPTR-1 functions by regulating worm AKT-1 phosphorylation at Thr (show TRH Antibodies) 350.

Goat V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) interaction partners

1. Exogenous AKT was transcribed, and AKT was overexpressed, inducing the phosphorylation of p70S6K (show RPS6KB1 Antibodies) (Thr389) and 4E-BP1 (show EIF4EBP1 Antibodies) (Thr37/46) in goat fetal fibroblasts.

Guinea Pig V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) interaction partners

1. findings suggested that the expressions of the cardiac CACNA1C (show CACNA1C Antibodies) were under the CLOCK-BMAL1 (show ARNTL Antibodies) regulation, probably through the PI3K-Akt signal pathway

Zebrafish V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) interaction partners

1. This study has identified Akt as a novel intracellular pathway required for neural crest differentiation.

2. Overexpression of human Akt1 enhances adipogenesis and leads to lipoma formation in zebrafish.