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Human CDK2 Protein expressed in Wheat germ - ABIN1348934
Bockstaele, Kooken, Libert, Paternot, Dumont, de Launoit, Roger, Coulonval: Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors". in Molecular and cellular biology 2006
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Analysis of genomic data from TCGA demonstrated coamplification of CCNE1 (show CCNE1 Proteins) and AKT2 (show AKT2 Proteins) Overexpression of Cyclin E1 (show CCNE1 Proteins) and AKT (show AKT1 Proteins) isoforms, in addition to mutant TP53 (show TP53 Proteins), imparted malignant characteristics in untransformed fallopian tube secretory cells, the dominant site of origin of high-grade serous ovarian cancer
WHSC1L1 (show WHSC1L1 Proteins) and H3K36me2 are enriched in the gene bodies of the cell cycle-related genes CDC6 (show CDC6 Proteins) and CDK2, implying that WHSC1L1 (show WHSC1L1 Proteins) directly regulates the transcription of these gene
Findings suggest that ERK1/2-mediated Cdk2/cyclin A (show CCNA2 Proteins) signaling pathway is involved in 7-hydroxy-5,4'-dimethoxy-2-arylbenzofuran (Ary) - induced G1/S-phase arrest.
CDK2 phosphorylates polyQ-AR specifically at Ser (show SIGLEC1 Proteins)(96). Phosphorylation of polyQ-AR by CDK2 increased protein stabilization and toxicity and is negatively regulated by the adenylyl cyclase/protein kinase A signaling pathway in spinobulbar muscular atrophy.
Data show that Noxa (show PMAIP1 Proteins)-mediated MCL-1 (show MCL1 Proteins) phosphorylation and degradation is regulated by CDK2.
Residual Cdk1 (show CDK1 Proteins)/Cdk2 activity after DNA damage promotes cell senescence.
evidence that CDK1 (show CDK1 Proteins)/2 participate in the regulation of constitutive pre-mRNA splicing by EGF (show EGF Proteins) stimulation in MDA-MB-468 cells.
The upregulation of miR (show MLXIP Proteins)-302b reduced the expression of CDK2, and inhibited ERK (show EPHB2 Proteins) signaling pathway, thereby inhibiting cell proliferation and G1/S phase conversion rate.
High CDK2 expression is associated with breast cancer.
Here, we introduce a transcriptional signature to specifically track CDK2 activity. It responds to genetic and chemical perturbations in the CDK (show CDK4 Proteins)-RB-E2F (show E2F1 Proteins) axis, correlates with mitotic rate in vitro and in vivo and reacts rapidly to changes in CDK2 activity during cell cycle progression
evidence that cyclin A1 (show CCNA1 Proteins)-associated activity is a mediator of apoptosis and that cyclin A1 (show CCNA1 Proteins)/Cdk2 is sufficient to induce apoptosis
Ad-p21 inhibits RNV in OIR. A potential underlying mechanism for this may be that overexpression of p21 arrests the cell cycle at the G1- to S-phase transition via inhibition of CDK2 activity.
CDK2 serves as an important nexus linking primary beta-cell dysfunction to progressive beta-cell mass deterioration in diabetes
data indicate that the essential meiotic functions of Cdk2 depend on its kinase activity, without which the generation of haploid cells is disrupted, resulting in sterility of otherwise healthy animals
Testosterone is the positive regulator of hepatocyte cell cycle via cyclin E (show CCNE1 Proteins)/cdk2 promoting hepatocarcinogenesis.
This approach allowed us to determine the identity of cyclin E (show CCNE1 Proteins) protein partners, as well as phosphorylation substrates of cyclins E (cyclin (show PCNA Proteins) E1and cyclin E2 (show CCNE2 Proteins))and its associated kinase, Cdk2, in different mouse organs.
RingoA (show SPDYA Proteins) is an important activator of Cdk2 at meiotic telomeres.
Foxo3 (show FOXO3 Proteins) circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2.
Results identify phosphorylation of CDK2 at tyrosine 160 as a gate-keeping mechanism for hepatocyte proliferation.
Sox2 (show SOX2 Proteins) phosphorylation by Cdk2 promotes the establishment but not the maintenance of the pluripotent state.
intestinal clock controls the expression of key cell cycle regulators, such as cdc2 (show CDK1 Proteins), wee1 (show WEE1 Proteins), p21 (show CDKN1A Proteins), PCNA (show PCNA Proteins) and cdk2, but only weakly influences cyclin B1 (show CCNB1 Proteins), cyclin B2 (show CCNB2 Proteins) and cyclin E1 (show CCNE1 Proteins) expression.
PI3-kinase (show PIK3CA Proteins) and Akt (show AKT1 Proteins) participate in insulin (show INS Proteins) stimulation of p34cdc2 (show CDK1 Proteins) activation in zebrafish oocyte with phosphodiesterase 3 as a potential downstream target.
an essential role for UHRF1 (show UHRF1 Proteins) phosphorylation by cyclin-dependent kinase 2/cyclin A2 (show CCNA2 Proteins) during early vertebrate development
cyclin D1 (show CCND1 Proteins), CDK2 and CDK4 (show CDK4 Proteins) are expressed in both caruncular and intercaruncular cells derived from both nonpregnant, and artificially inseminated cows on days 30 and 60 of gestation
our results indicate that an ATM (show ATM Proteins)-P53 (show TP53 Proteins)-P21 (show CDKN1A Proteins) DNA damage checkpoint is intact in the absence of CDK2; however, CDK2 is important for proper repair of the damaged DNA by either directly or indirectly influencing DNA repair-related gene expression.
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported.
cdc2-related protein kinase
, cell devision kinase 2
, cell division protein kinase 2
, p33 protein kinase
, Cyclin-dependent kinase 2-interacting protein
, cyclin-dependent kinase 2 interacting protein
, cyclin-dependent kinase 2-interacting protein
, MGC84068 protein
, cyclin dependent kinase 2-alpha
, cyclin-dependent kinase 2
, CDC2 homolog Eg1 protein kinase
, Cell division protein kinase 2