Browse our anti-FOXO1 (FOXO1) Antibodies

Human Forkhead Box O1 (FOXO1) interaction partners

1. miR-9 enhances invasion and migration of cervical carcinomas by directly targeting FOXO1.

2. Authors show that the molecular and functional longevity of a memory T cell population is actively maintained by the transcription factor FOXO1.

3. FOXO1 directly regulates VEGFA expression, promoting normal angiogenesis during wound healing.

4. Overexpression of nuclear FOXO1 and loss of cytoplasmic pSerine256-FOXO1 expression are associated with poor prognosis in patients with EACs.

5. findings highlight a novel FoxO1/HMGA1-mediated mechanism by which insulin may regulate gene expression and metabolism.

6. Our data indicate that H2 S is a novel regulator of FoxO1 in cardiac cells and provide evidence supporting the potential of hydrogen sulfide in inhibiting the progression of diabetic cardiomyopathy .

7. The study aimed to investigate the impact of miR-182 and FOXO1 on S. japonica-induced hepatic fibrosis. Microarray analysis was performed to screen out differential expressed miRNAs and mRNAs. Rat hepatic fibrosis model and human hepatocellular cell line LX-2 were used to study the effect of miR-182 and FOXO1

8. The FOXO1 are critical regulators of Intervertebral disk (IVD) homeostasis during aging and suggest that maintaining or restoring FOXO1 expression can be a therapeutic strategy to promote healthy IVD aging and delay the onset of IVD degeneration.

9. study demonstrates that LINC01619 functions as a competing endogenous RNA and regulates miR-27a/FOXO1-mediated ER stress and podocyte injury in diabetic nephropathy

10. results suggest that age-associated dysregulation of splicing factor expression and cellular senescence may derive in part from altered activity of ERK and AKT signaling and may act in part through the ETV6 and FOXO1 transcription factors

11. Upregulated circulating miR-139 level may be a potential biomarker for patients with metabolic disorders via suppressing the expression of forkhead box O1(FoxO1) and forkhead box P1 (FoxP1).

12. Fusion genes involving forkhead box protein O1 (FOXO1) were detected in 56 of 84 patients. Events occurred in 52 patients: 43 developed disease recurrence, 7 had disease that was refractory to treatment, and 2 patients developed second neoplasms

13. Sirtuin 1/forkhead box O1/sterol regulatory element binding protein-1 act as a pathway targeting progesterone receptor and involve in the development of progestin resistance in Ishikawa cells.

14. the inhibition of Alveolar rhabdomyosarcoma cell proliferation, survival, and migration after knockdown of PAX3-FOXO1 was significantly (>75%) reversed by knockdown of IL24.

15. MiR-490-3p inhibits osteogenic differentiation in thoracic ligamentum flavum cells by targeting FOXO1

16. The novel FOXO1/LINC01197/b-catenin axis was dysregulated during pancreatic ductal adenocarcinoma (PDAC)progression. Our study provides insight into the mechanisms of LINC01197 in PDAC and reveal a potential target for PDAC clinical therapy and prognostic prediction.

17. we reported that FOXO1 is methylated by G9a at K273 residue in vitro and in vivo. Methylation of FOXO1 by G9a increased interaction between FOXO1 and a specific E3 ligase, SKP2, and decreased FOXO1 protein stability.

18. These results demonstrate that FoxO1 promotes differentiation and apoptosis in HPKs.

19. These results suggest that TRB1 suppresses the expression of G6Pase and PEPCK by attenuating FOXO1 transcriptional activity and negatively regulates gluconeogenesis.

20. Data show that menin stabilizes forkhead box O1 protein (FOXO1) by repressing FOXO1 degradation mediated by S-phase kinase-associated protein 2 (Skp2).

Zebrafish Forkhead Box O1 (FOXO1) interaction partners

1. The findings reveal a novel mechanism by which Ca2+ overload disrupts myofibril integrity by activating a Calcineurin-FoxO-MuRF1-proteosome signaling pathway.

2. These results indicate that miR-182 functions as a FoxO1 inhibitor to antagonize osteoblast proliferation and differentiation, with a subsequent negative effect on osteogenesis.

3. gas6 protects endothelial cells from apoptosis by a mechanism that involves PI3K-Akt-dependent inactivation of FOXO1a.

Mouse (Murine) Forkhead Box O1 (FOXO1) interaction partners

1. These findings indicated roles for FoxO1 in tip-cell migration and that its transcriptional activity is regulated by hypoxia.

2. FOXO1 directly regulates VEGFA expression, promoting normal angiogenesis during wound healing.

3. Gomafu functioned as miR-139 sponge and led to the de-repression of its target gene Foxo1, which played an important role in gluconeogenesis in hepatocytes.

4. Hippo/MST downregulation has a critical role in PAX3-FOXO1-positive rhabdomyosarcoma tumorigenesis

5. findings highlight a novel FoxO1/HMGA1-mediated mechanism by which insulin may regulate gene expression and metabolism.

6. The FOXO1 are critical regulators of Intervertebral disk (IVD) homeostasis during aging and suggest that maintaining or restoring FOXO1 expression can be a therapeutic strategy to promote healthy IVD aging and delay the onset of IVD degeneration.

7. Inhibition of miR-182-5p attenuated symptoms associated with lupus nephritis and the effect was associated with the activation of Foxo1 signaling.

8. Study data indicates that insulin regulates adrenal steroidogenesis by up regulating the transcriptional activity of SF-1 both in vitro and in vivo. Overexpression of FoxO1, a downstream transcription factor regulated by insulin, inhibits the expression and transcriptional activity of SF-1 suggesting that insulin might increase the activity of SF-1 by phosphorylating and inactivating FoxO1.

9. study has revealed a new intracellular mechanism in which Akt2 regulates ICOS expression via FoxO-1 and this signaling axis regulates the differentiation and function of NKT17 cells. This study provides a new linker between cell metabolism and function of iNKT cells.

10. Recurrent FOXO1 mutations, which prevent AKT targeting and lock the transcription factor in the nucleus, are used by BL to circumvent mutual exclusivity between PI3K and FOXO1 activation

11. age-related muscle weight loss tended to be suppressed in the LC-Plasma group and expression of the muscle degeneration gene FoxO-1 was significantly suppressed. Related to these phenotypes, the senescence score in the LC-Plasma group was significantly decreased at 47weeks of age compared with that in the control group.

12. CK2 regulates the Th17/Treg axis through the inhibition of FoxO1.

13. further mechanism research indicated that sweroside could activate the SIRT1, then suppress the nuclear factor-kappa B (NF-kappaB) and promote the Forkhead transcription factor O1 (FOXO1) signaling pathways

14. this study demonstrates maintenance of CD4 T cell fitness through regulation of Foxo1

15. Insulin suppression of gluconeogenic enzyme expression is facilitated by coordinated inactivation of FoxO1 and PGC-1alpha by WD40/ProF-associated Akt; but this coordination also increases vulnerability to aPKC hyperactivity, which is abetted by SREBP-1c-induced increases in PGC-1alpha and PKC-iota.

16. SIRT6 deficiency results in decreased oxygen consumption rate and concomitantly lesser ATP production. Mechanistically, SIRT6 deficiency leads to increased FoxO1-mediated transcription of PDK4. Our findings establish a novel link between SIRT6 and cardiac metabolism, suggesting a protective role of SIRT6 in maintaining cardiac homeostasis.

17. This work establishes a novel molecular mechanism of mood behavior regulation by leptin and suggests FoxO1 suppression by leptin might be a key for leptin-induced behavioral manifestation

18. FOXO1 deletion in keratinocytes improves re-epithelialization of diabetic wound via MMP9 regulation.

19. These results indicate that liver FoxO1 promotes serpinB1 expression in hepatic insulin resistance and that non-cell-autonomous factors contribute to FoxO1-dependent effects on serpinB1 expression in the liver.

20. FOXO1 is continuously required for all the phenotypic characteristics of memory-effector T cells such that with acute inactivation of the gene encoding FOXO1, T cells revert to a short-lived effector phenotype, exhibit reduced viability, and manifest characteristics of anergy.

Pig (Porcine) Forkhead Box O1 (FOXO1) interaction partners

1. FOXO1-suppressed miR-424 regulates both the proliferation and osteogenic differentiation of mesenchymal stem cells via targeting FGF2.

2. Studied the effects of microRNA-27a on myogenin expression and the Akt/FoxO1 signal pathway during porcine myoblast differentiation. Overexpression of miR-27a suppressed myogenin expression during porcine myoblast differentiation, whereas inhibition of miR-27a promoted the mRNA and protein expression levels of myogenin; overexpression of miR-27a decreased the level of P-Akt/Akt and increased the protein level of FoxO1.

3. he knockdown of FoxO1 repressed lipogenesis by downregulating PDGFRalpha, and miR-34a inhibited adipogenesis through targeting PDGFRalpha.

4. These results indicate glycine enhances muscle protein mass under an inflammatory condition. The beneficial roles of glycine on the muscle are closely associated with maintaining Akt-mTOR-FOXO1 signaling and suppressing the activation of TLR4 and/or NOD2 signaling pathways.

5. let-7g induces porcine granulosa cells apoptosis by inhibiting the MAP3K1 gene, which promotes FoxO1 expression and dephosphorylation with nuclear accumulation.

6. inhibition of FoxO1 expression level caused by miR-15a/b over-expression had a positive effect on adipogenesis. Thus, we conclude that miR-15a/b promote adipogenesis in porcine pre-adipocyte via repressing FoxO1

7. Results show that FoxO1 likely regulates MyHC I negatively and MyHC IIx and MyHC IIb positively and may play a pivotal role in the determination of muscle fiber type.

8. Data suggest forkhead box protein O1 (FoxO1) involvement in the regulation of TNF-related apoptosis-inducing ligand TRAIL and Fas ligand FasL expression during follicular atresia.

9. Data show that IL-4 induces upregulation of the junction protein claudin-5 in endothelial cells (ECs) through activation of Jak/STAT6 and phosphorylation and translocation of FoxO1 from the nucleus to the cytoplasm.

10. FoxO1 and C/EBPb regulate preadipocyte adipogenesis possibly through C/EBPb-> FoxO1-> C/EBPb feedback regulatory loop and FoxO1-C/EBPb protein complex.

11. FoxO1 delays and negatively regulates the porcine myoblast differentiation. It may also play a critical role in muscle fiber-type specification through the inhibition of myogenic regulation factors.

12. concluded that PI 3-kinase and Akt are activated after renal ischemia/reperfusion and that Akt phosphorylation leads to phosphorylation of FKHR and FKHRL1, which may affect epithelial cell fate in acute renal failure.

13. FoxO1a can regulate p27kip nuclear localization

14. FoxO1 expression level has a negative correlation with the development of muscle fiber

15. results suggested that porcine FoxO1 gene took part in the regulation of adipose and was a negative transcription regulation factor in preadipocyte differentiation

Cow (Bovine) Forkhead Box O1 (FOXO1) interaction partners

1. This is the first study demonstrating a role for AMPK-SIRT1-FOXO1 signalling pathway in regulating apoptosis in bovine intramuscular adipocytes.

2. MicroRNA-183-96-182 cluster regulates bovine granulosa cell function by targeting FOXO1 gene.

3. downregulation of SIRT1 and FoxO1 were observed in the backfat tissue of Lilu cattle with increasing age

4. Animals with genotype AA at SNP A176183G in FOX01 had significantly greater body length, chest breadth and chest depth than those with genotypes AG and GG.

5. FOXO is a key regulator of ROS-induced apoptosis in mammalian cells.

6. Protein kinase A-alpha directly phosphorylates FoxO1 in vascular endothelial cells to regulate expression of vascular cellular adhesion molecule-1 mRNA.

7. The results demonstrate pathways through which two different mediators, TNF-alpha and an advanced glycation endproduct, can induce pericyte apoptosis through activation of the transcription factor FOXO1.

Rhesus Monkey Forkhead Box O1 (FOXO1) interaction partners

1. FOXO1, 3, and 4 as well as their upstream regulator, AKT/p-AKT, was examined in rhesus macaque ovaries of three developmental stages: fetal, prepubertal, and adult

Xenopus laevis Forkhead Box O1 (FOXO1) interaction partners

1. FoxO1 translocation to the nucleus, and the increase in FoxO1 DNA binding activity in X. laevis liver strongly correlate with the up-regulation of manganese-dependent superoxide dismutase and catalase mRNA and protein levels in this organ.