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anti-Human FOXO1 Antibodies:
anti-Rat (Rattus) FOXO1 Antibodies:
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Human Polyclonal FOXO1 Primary Antibody for ICC, IF - ABIN250693
Hoekstra, Sefton, Berry, Lu, Hardt, Marsh, Yin, Clardy, Chakravarti, Bulun, Kim: Progestins activate the AKT pathway in leiomyoma cells and promote survival. in The Journal of clinical endocrinology and metabolism 2009
Show all 8 Pubmed References
Human Polyclonal FOXO1 Primary Antibody for IHC - ABIN966149
Zhao, Gan, Pan, Kan, Majeski, Adam, Unterman: Multiple elements regulate nuclear/cytoplasmic shuttling of FOXO1: characterization of phosphorylation- and 14-3-3-dependent and -independent mechanisms. in The Biochemical journal 2004
Show all 4 Pubmed References
Human Polyclonal FOXO1 Primary Antibody for IF, IHC - ABIN362088
Zhan, Wang, Li, Xu, Sun, Xu: Activation of Akt/FoxO signaling pathway contributes to induction of neuroprotection against transient global cerebral ischemia by hypoxic pre-conditioning in adult rats. in Journal of neurochemistry 2010
Show all 3 Pubmed References
Human Polyclonal FOXO1 Primary Antibody for IHC (fro), IF - ABIN4948288
Sajan, Ivey, Lee, Mastorides, Jurczak, Samuels, Shulman, Braun, Leitges, Farese: PKC? haploinsufficiency prevents diabetes by a mechanism involving alterations in hepatic enzymes. in Molecular endocrinology (Baltimore, Md.) 2014
Show all 3 Pubmed References
Human Monoclonal FOXO1 Primary Antibody for ICC, IHC - ABIN969521
Lau, Koty, Nalbantoglu: Differential response of glioma cells to FOXO1-directed therapy. in Cancer research 2009
Show all 2 Pubmed References
Human Polyclonal FOXO1 Primary Antibody for IHC - ABIN966148
Gan, Zheng, Chabot, Unterman, Quirion: Nuclear/cytoplasmic shuttling of the transcription factor FoxO1 is regulated by neurotrophic factors. in Journal of neurochemistry 2005
Show all 2 Pubmed References
Human Polyclonal FOXO1 Primary Antibody for ICC, IF - ABIN4312363
Sahu, Laakso, Ovaska, Mirtti, Lundin, Rannikko, Sankila, Turunen, Lundin, Konsti, Vesterinen, Nordling, Kallioniemi, Hautaniemi, Jänne: Dual role of FoxA1 in androgen receptor binding to chromatin, androgen signalling and prostate cancer. in The EMBO journal 2011
Show all 2 Pubmed References
Human Polyclonal FOXO1 Primary Antibody for IF (p), IHC (p) - ABIN684748
Li, Qiu, Liu, Wang, Hu, Gan, Wang: Long-term thermal manipulation in the late incubation period can inhibit breast muscle development by activating endoplasmic reticulum stress in duck (Anasplatyrhynchos domestica). in Journal of thermal biology 2017
Human Polyclonal FOXO1 Primary Antibody for IF, IHC - ABIN362738
Smith, Norton, Gorospe, Jiang, Nemoto, Holbrook, Finkel, Kusiak: Phosphorylation of p66Shc and forkhead proteins mediates Abeta toxicity. in The Journal of cell biology 2005
Show all 6 Pubmed References
Human Polyclonal FOXO1 Primary Antibody for ELISA, WB - ABIN252951
Paik, Kollipara, Chu, Ji, Xiao, Ding, Miao, Tothova, Horner, Carrasco, Jiang, Gilliland, Chin, Wong, Castrillon, DePinho: FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. in Cell 2007
MiR (show MLXIP Antibodies)-145 could suppress human adipose-derived mesenchymal stem cells osteoinductive differentiation by suppressing FoxO1 directly.
Here the authors identified a direct interaction of both MEK1 (show MAP2K1 Antibodies) and MEK2 (show MAP2K2 Antibodies) with AKT (show AKT1 Antibodies). The interaction between MEK (show MAP2K1 Antibodies) and AKT (show AKT1 Antibodies) affects cell migration and adhesion, but not proliferation. The specific mechanism of action of the MEK (show MAP2K1 Antibodies)-AKT (show AKT1 Antibodies) complex involves phosphorylation of the migration-related transcription factor FoxO1.
our study identified that p27 (show PAK2 Antibodies) expression was transcriptionally upregulated by enhancing the binding of FOXO1 to its promoter and post-transcriptionally induced through decreasing binding of miR (show MLXIP Antibodies)-182 to its mRNA 3'-UTR (show UTS2R Antibodies) upon isorhapontigenin treatment
rescue experiments demonstrated that FOXO1 knockdown abolished the effects of miR660 knockdown on osteosarcoma (OS)cell proliferation and invasion. These results suggest that miR660 may serve oncogenic roles in OS by directly targeting FOXO1. Targeting miR660 may be an effective candidate for the treatment of patients with OS.
In particular, we discuss molecular mechanisms that might determine the switch between pro-apoptotic and pro-survival effects of FOXO1 and their interplay with specific differentiation programs.
In this review, we will discuss the current knowledge regarding potential therapeutic targets that might contribute to indirect interference with PAX3 (show PAX3 Antibodies)-FOXO1 activity in alveolar rhabdomyosarcoma at the different molecular levels and extrapolate these findings to fusion transcription factors in general.
This review aims to serve as a guide for further research and implicate FOXO1 as a potent therapeutic target in digestive malignancy.
Low FOXO1 expression is associated with ovarian cancer.
Foxo1 is involved in estradiol 17beta-mediated proliferation in INS1 (show FOXM1 Antibodies)-E cells and human islets.
apicidin induced the acetylation of Forkhead box (show FOXO Antibodies)-containing protein, O subfamily 1, which acts as a repressor at the IL7R (show IL7R Antibodies) promoter, accompanied with depleted active histone modifications based on chromatin immunoprecipitation assay. Taken together, these results demonstrated that targeting oncogenic IL7R (show IL7R Antibodies) in ESCC by HDAC (show HDAC3 Antibodies) inhibitors may be a valuable therapeutic approach.
The findings reveal a novel mechanism by which Ca2 (show CA2 Antibodies)+ overload disrupts myofibril integrity by activating a Calcineurin-FoxO (show FOXO3 Antibodies)-MuRF1 (show TRIM63 Antibodies)-proteosome signaling pathway.
These results indicate that miR (show MYLIP Antibodies)-182 functions as a FoxO1 inhibitor to antagonize osteoblast proliferation and differentiation, with a subsequent negative effect on osteogenesis.
gas6 (show GAS6 Antibodies) protects endothelial cells from apoptosis by a mechanism that involves PI3K-Akt (show AKT1 Antibodies)-dependent inactivation of FOXO1a.
Furthermore, chromatin immunoprecipitation (ChIP) followed by luciferase assays revealed direct binding of Foxo1 to both the Il9 (show IL9 Antibodies) and Irf4 (show IRF4 Antibodies) promoters and induces their transactivation.
Japanese encephalitis virus (JEV) induced cell apoptosis by inhibiting STAT3 (show STAT3 Antibodies)-Foxo (show FOXO3 Antibodies)-Bcl-6 (show BCL6 Antibodies)/p21 (show D4S234E Antibodies) pathway, which provides a novel insight into JEV-caused encephalitis.
data reveal the pervasive role of forkhead box O1(FoxO1) in mediating the effects of insulin (show INS Antibodies) on not only glucose metabolism but also other hormonal signaling pathways and even some aspects of lipid metabolism
FOXO1 deletion in epithelium led to impaired healing that included decreased formation of new connective tissue.
Distinct levels of phosphorylated FoxO1 were observed.
the results of the present study suggest that moderate overexpression of SIRT1 (~3fold of normal level) may directly or indirectly inhibit apoptosis of OBs via the FOXO1 and betacatenin signaling pathway.
insulin (show INS Antibodies)-activated SREBP1c (show SREBF1 Antibodies) downregulates gluconeogenesis through CRY1 (show CRY1 Antibodies)-mediated FOXO1 degradation.
Our study demonstrated that Arachidonic acid (AA) inhibits macrophage viability by inducing S phase cell cycle arrest. The JNK (show MAPK8 Antibodies) signaling pathway and the downstream FoxO (show FOXO3 Antibodies) transcription factors are involved in AA-induced RAW264.7 cell cycle arrest.
the transcription of Rho-associated coiled-coil containing protein kinase 1 (ROCK1 (show ROCK1 Antibodies)), which phosphorylates Drp1 (show CRMP1 Antibodies) at Ser616, was shown by luciferase assay to be directly regulated by FOXO1. These findings suggested that FOXO1 is critical to preserve mitochondrial quantity and function in ECs, and FOXO1 may serve as a therapeutic target for microvascular complications of diabetes.
Chimeric antigen receptor T cells releasing IL-18 (show IL18 Antibodies) convert to T-Bet(high) FoxO1(low) effectors that exhibit augmented activity against advanced solid tumors.
FOXO1-suppressed miR (show MYLIP Antibodies)-424 regulates both the proliferation and osteogenic differentiation of mesenchymal stem cells via targeting FGF2 (show FGF2 Antibodies).
Studied the effects of microRNA-27a on myogenin (show MYOG Antibodies) expression and the Akt (show AKT1 Antibodies)/FoxO1 signal pathway during porcine myoblast differentiation. Overexpression of miR (show MYLIP Antibodies)-27a suppressed myogenin (show MYOG Antibodies) expression during porcine myoblast differentiation, whereas inhibition of miR (show MYLIP Antibodies)-27a promoted the mRNA and protein expression levels of myogenin (show MYOG Antibodies); overexpression of miR (show MYLIP Antibodies)-27a decreased the level of P-Akt/Akt (show AKT1 Antibodies) and increased the protein level of FoxO1.
he knockdown of FoxO1 repressed lipogenesis by downregulating PDGFRalpha, and miR (show MYLIP Antibodies)-34a inhibited adipogenesis through targeting PDGFRalpha.
These results indicate glycine enhances muscle protein mass under an inflammatory condition. The beneficial roles of glycine on the muscle are closely associated with maintaining Akt (show AKT1 Antibodies)-mTOR (show FRAP1 Antibodies)-FOXO1 signaling and suppressing the activation of TLR4 (show TLR4 Antibodies) and/or NOD2 (show NOD2 Antibodies) signaling pathways.
let-7g induces porcine granulosa cells apoptosis by inhibiting the MAP3K1 (show MAP3K1 Antibodies) gene, which promotes FoxO1 expression and dephosphorylation with nuclear accumulation.
inhibition of FoxO1 expression level caused by miR (show MYLIP Antibodies)-15a/b over-expression had a positive effect on adipogenesis. Thus, we conclude that miR (show MYLIP Antibodies)-15a/b promote adipogenesis in porcine pre-adipocyte via repressing FoxO1
Results show that FoxO1 likely regulates MyHC I (show MYH7 Antibodies) negatively and MyHC IIx and MyHC IIb (show MYH4 Antibodies) positively and may play a pivotal role in the determination of muscle fiber type.
Data suggest forkhead box protein O1 (FoxO1) involvement in the regulation of TNF-related apoptosis-inducing ligand TRAIL (show TNFSF10 Antibodies) and Fas ligand FasL (show FASL Antibodies) expression during follicular atresia.
Data show that IL-4 (show IL4 Antibodies) induces upregulation of the junction protein claudin-5 (show CLDN5 Antibodies) in endothelial cells (ECs) through activation of Jak (show JAK3 Antibodies)/STAT6 (show STAT6 Antibodies) and phosphorylation and translocation of FoxO1 from the nucleus to the cytoplasm.
FoxO1 and C/EBPb (show CEBPB Antibodies) regulate preadipocyte adipogenesis possibly through C/EBPb (show CEBPB Antibodies)-> FoxO1-> C/EBPb (show CEBPB Antibodies) feedback regulatory loop and FoxO1-C/EBPb (show CEBPB Antibodies) protein complex.
This is the first study demonstrating a role for AMPK (show PRKAA1 Antibodies)-SIRT1 (show SIRT1 Antibodies)-FOXO1 signalling pathway in regulating apoptosis in bovine intramuscular adipocytes.
MicroRNA-183-96-182 cluster regulates bovine granulosa cell function by targeting FOXO1 gene.
downregulation of SIRT1 (show SIRT1 Antibodies) and FoxO1 were observed in the backfat tissue of Lilu cattle with increasing age
FOXO (show FOXO3 Antibodies) is a key regulator of ROS (show ROS1 Antibodies)-induced apoptosis in mammalian cells.
Protein kinase A-alpha directly phosphorylates FoxO1 in vascular endothelial cells to regulate expression of vascular cellular adhesion molecule (show NCAM1 Antibodies)-1 mRNA.
The results demonstrate pathways through which two different mediators, TNF-alpha (show TNF Antibodies) and an advanced glycation endproduct, can induce pericyte apoptosis through activation of the transcription factor FOXO1.
FOXO1, 3, and 4 as well as their upstream regulator, AKT/p-AKT (show AKT1 Antibodies), was examined in rhesus macaque ovaries of three developmental stages: fetal, prepubertal, and adult
FoxO1 translocation to the nucleus, and the increase in FoxO1 DNA binding activity in X. laevis liver strongly correlate with the up-regulation of manganese-dependent superoxide dismutase (show SOD1 Antibodies) and catalase (show CAT Antibodies) mRNA and protein levels in this organ.
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined\; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma.
forkhead box protein O1
, forkhead box protein O1A
, forkhead, Drosophila, homolog of, in rhabdomyosarcoma
, forkhead box O1A
, forkhead box protein O1-A
, fox family transcription factor FoxO1a.1
, foxhead box protein O1-A
, Forkhead box protein O1A
, Forkhead in rhabdomyosarcoma
, forkhead box O1A (rhabdomyosarcoma)
, forkhead box O1a
, forkhead in rhabdomyosarcoma
, forkhead protein 1
, forkhead/winged helix transcription factor FOXO1a
, forkhead box O1
, forkhead box protein O1-like