Browse our anti-FOXO1 (FOXO1) Antibodies

Human Forkhead Box O1 (FOXO1) interaction partners

1. the present study demonstrated that the expression of miR (show MLXIP Antibodies)-196a in human liver cancer cells was upregulated; downregulation of miR (show MLXIP Antibodies)-196a regulated human liver cancer cell biological functions which could benefit the clinical therapy of human liver cancer in the future

2. Inhibition of FOXO1 enhanced angiogenesis in human bio-engineered capillaries, and resulted in microvascular regeneration and improved function in mouse models of injury-repair.

3. Cells harboring the fusion gene are selectively sensitive to small-molecule inhibition of protein targets induced by, or bound to, PAX3 (show PAX3 Antibodies)-FOXO1-occupied super enhancers. Furthermore, PAX3 (show PAX3 Antibodies)-FOXO1 recruits and requires the BET bromodomain protein BRD4 (show BRD4 Antibodies) to function at super enhancers, resulting in a complete dependence on BRD4 (show BRD4 Antibodies) and a significant susceptibility to BRD inhibition

4. FOXO1 silencing also augmented the migratory behavior of SW-13 cells (p<0.0001), suggesting distinct roles for FOXO1 in promoting viability and controlled motility of adrenocortical cells.

5. the miRNA-223can maintain cell proliferation of breast cancer cell through targeting FOXO 1.

6. MEG3 (show FAM129B Antibodies) acts as a ceRNA to regulate expression of E-cadherin (show CDH1 Antibodies) and FOXO1 by competitively binding miR (show MLXIP Antibodies)-9 and may be used as a potential biomarker in predicting ESCC patients' progression and prognosis

7. These results strongly suggest that AMPK (show PRKAA1 Antibodies) can activate ORP150 (show HYOU1 Antibodies) through FOXO1 pathway and confer protection against endoplasmic reticulum stress - induced apoptosis of airway epithelial cells following exposure to cigarette smoke extract.

8. LAT1 (show LAT Antibodies)-NAD+-SIRT1 (show SIRT1 Antibodies) signaling is activated in tumor tissues of patients with non-small cell lung cancer; NAD+ synthesis regulates the SIRT1 (show SIRT1 Antibodies)-FOXO1 apoptotic pathway in response to NQO1 (show NQO1 Antibodies)

9. Knockdown of FOXO4 (show FOXO4 Antibodies) but not FOXO1 expression decreased proteasome activity. Following neural differentiation, the HD-iPSC-derived neural progenitor cells (NPCs) demonstrated lower levels of proteasome activity and FOXO (show FOXO3 Antibodies) expressions than their WT counterparts. More importantly, overexpression of FOXO4 (show FOXO4 Antibodies) but not FOXO1 in HD NPCs dramatically enhanced proteasome activity.

10. The borders of this novel topologically associating domains (TADs)correspond to the original 5'- and 3'- borders of the PAX3 (show PAX3 Antibodies) and FOXO1 TADs, respectively, suggesting that TAD (show CRTAM Antibodies) organisation precedes the formation of regulatory long-range interactions. Our results demonstrate that, upon translocation, novel regulatory landscapes are formed allowing new intra-TAD (show CRTAM Antibodies) interactions between the original loci involved

Zebrafish Forkhead Box O1 (FOXO1) interaction partners

1. These results indicate that miR (show MYLIP Antibodies)-182 functions as a FoxO1 inhibitor to antagonize osteoblast proliferation and differentiation, with a subsequent negative effect on osteogenesis.

2. gas6 (show GAS6 Antibodies) protects endothelial cells from apoptosis by a mechanism that involves PI3K-Akt (show AKT1 Antibodies)-dependent inactivation of FOXO1a.

Mouse (Murine) Forkhead Box O1 (FOXO1) interaction partners

1. Inhibition of FOXO1 enhanced angiogenesis in human bio-engineered capillaries, and resulted in microvascular regeneration and improved function in mouse models of injury-repair.

2. Authors found that the repress effect of alphaMSH (show POMC Antibodies) in adipocytes apoptosis is acting through Foxo1/mTORC2 (show CRTC2 Antibodies) pathway. These findings indicate that, alphaMSH (show POMC Antibodies) has a strong inhibitory effect on ROS (show ROS1 Antibodies)-induced adipocyte apoptosis and underlying mechanism is interacting with key factors in mTOR (show FRAP1 Antibodies) signal pathway.

3. Sirt3 (show SIRT3 Antibodies) activation is essential to improve autophagy flux by reducing the acetylation modification on FoxO1, which in turn alleviates myocardial hypertrophy.

4. The data reveal a novel mechanism in which the elevated miR (show MLXIP Antibodies)-425 in IBD mediates pathogenic Th17 cell generation through down-regulation of Foxo1.

5. we found that in db/db (show LEPR Antibodies) VSMC, the occupancy in promoter regions of inflammatory genes by FOXO1 was reduced.miR-135a increased the inflammatory responses of VSMC involved in complications of vascular diseases by downregulating the expression of FOXO1.

6. Trehalose may rescue against insulin (show INS Antibodies) resistance-induced myocardial contractile defect and apoptosis, via autophagy associated with dephosphorylation of p38 MAPK (show MAPK14 Antibodies) and Foxo1 without affecting phosphorylation of Akt (show AKT1 Antibodies).

7. FoxO1 is a key mediator involved in glucose homeostasis and indicate that 1,25(OH)2D3 improves glucose metabolism and bone development

8. Data show that the mitochondrial enriched GCN5 (show KAT2A Antibodies)-like 1 protein (GCN5L1 (show BLOC1S1 Antibodies)) controls hepatic glucose production by regulating FoxO1 protein levels.

9. Setdb1 (show SETDB1 Antibodies) regulates PTEN/AKT (show AKT1 Antibodies)/FOXO1 pathway to inhibit Spermatogonial stem cells apoptosis.

10. These findings indicate that IGF-II reduces PGC-1alpha expression in skeletal muscle cells through a mechanism involving PI3K-Akt (show AKT1 Antibodies)-FoxO1 but not p38 MAPK (show MAPK14 Antibodies) or Erk1/2 MAPK (show MAPK1 Antibodies) pathways.

Pig (Porcine) Forkhead Box O1 (FOXO1) interaction partners

1. These results indicate glycine enhances muscle protein mass under an inflammatory condition. The beneficial roles of glycine on the muscle are closely associated with maintaining Akt (show AKT1 Antibodies)-mTOR (show FRAP1 Antibodies)-FOXO1 signaling and suppressing the activation of TLR4 (show TLR4 Antibodies) and/or NOD2 (show NOD2 Antibodies) signaling pathways.

2. let-7g induces porcine granulosa cells apoptosis by inhibiting the MAP3K1 (show MAP3K1 Antibodies) gene, which promotes FoxO1 expression and dephosphorylation with nuclear accumulation.

3. inhibition of FoxO1 expression level caused by miR (show MYLIP Antibodies)-15a/b over-expression had a positive effect on adipogenesis. Thus, we conclude that miR (show MYLIP Antibodies)-15a/b promote adipogenesis in porcine pre-adipocyte via repressing FoxO1

4. Results show that FoxO1 likely regulates MyHC I (show MYH7 Antibodies) negatively and MyHC IIx and MyHC IIb (show MYH4 Antibodies) positively and may play a pivotal role in the determination of muscle fiber type.

5. Data suggest forkhead box protein O1 (FoxO1) involvement in the regulation of TNF-related apoptosis-inducing ligand TRAIL (show TNFSF10 Antibodies) and Fas ligand FasL (show FASL Antibodies) expression during follicular atresia.

6. Data show that IL-4 (show IL4 Antibodies) induces upregulation of the junction protein claudin-5 (show CLDN5 Antibodies) in endothelial cells (ECs) through activation of Jak (show JAK3 Antibodies)/STAT6 (show STAT6 Antibodies) and phosphorylation and translocation of FoxO1 from the nucleus to the cytoplasm.

7. FoxO1 and C/EBPb (show CEBPB Antibodies) regulate preadipocyte adipogenesis possibly through C/EBPb (show CEBPB Antibodies)-> FoxO1-> C/EBPb (show CEBPB Antibodies) feedback regulatory loop and FoxO1-C/EBPb (show CEBPB Antibodies) protein complex.

8. FoxO1 delays and negatively regulates the porcine myoblast differentiation. It may also play a critical role in muscle fiber-type specification through the inhibition of myogenic regulation factors.

9. concluded that PI 3 (show PI3 Antibodies)-kinase and Akt (show AKT1 Antibodies) are activated after renal ischemia/reperfusion and that Akt (show AKT1 Antibodies) phosphorylation leads to phosphorylation of FKHR and FKHRL1 (show FOXO3 Antibodies), which may affect epithelial cell fate in acute renal failure.

10. FoxO1a can regulate p27kip nuclear localization

Cow (Bovine) Forkhead Box O1 (FOXO1) interaction partners

1. MicroRNA-183-96-182 cluster regulates bovine granulosa cell function by targeting FOXO1 gene.

2. downregulation of SIRT1 (show SIRT1 Antibodies) and FoxO1 were observed in the backfat tissue of Lilu cattle with increasing age

3. FOXO (show FOXO3 Antibodies) is a key regulator of ROS (show ROS1 Antibodies)-induced apoptosis in mammalian cells.

4. Protein kinase A-alpha directly phosphorylates FoxO1 in vascular endothelial cells to regulate expression of vascular cellular adhesion molecule (show NCAM1 Antibodies)-1 mRNA.

5. The results demonstrate pathways through which two different mediators, TNF-alpha (show TNF Antibodies) and an advanced glycation endproduct, can induce pericyte apoptosis through activation of the transcription factor FOXO1.

Xenopus laevis Forkhead Box O1 (FOXO1) interaction partners

1. FoxO1 translocation to the nucleus, and the increase in FoxO1 DNA binding activity in X. laevis liver strongly correlate with the up-regulation of manganese-dependent superoxide dismutase (show SOD1 Antibodies) and catalase (show CAT Antibodies) mRNA and protein levels in this organ.