Browse our anti-FOXO1 (FOXO1) Antibodies

Human Forkhead Box O1 (FOXO1) interaction partners

1. miR-215 promotes cell migration and invasion of gastric cancer by targeting FOXO1.

2. these results provide a mechanism for how interdependent FoxO1:FoxA1/2 binding is negatively impacted by insulin and provide a developmental context for cooperative gene activation by these factors.

3. FOXO1 is involved in establishing endothelial tip cell polarity during sprouting angiogenesis. MST1 (Stk4) regulates FOXO1 localization at tip endothelial cells.

4. PAX3-FOXO1 regulates key microRNAs that may represent novel therapeutic vulnerabilities in fusion positive Rabdomyosarcomas.

5. miR-486-5p can inhibit inflammatory response, ECM degradation and apoptosis in NP cells by directly targeting FOXO1, which may contribute to the biological therapy of intervertebral disc degeneration.

6. Low FOXO1 expression is associated with cancer.

7. The reciprocal expression of PGR and FOXO1 was conserved in endometrial samples during the proliferative and secretory phase. Expression of FOXO1 and the loss of PGR during the window of receptivity are interrelated and critical for embryo implantation.

8. The presence of FOXO1 (and SESN3 and TSC2) were identified in Lewy bodies from brainstem.

9. There is strong indication of involving FOXO1 (Forkhead Box O1) gene-a strong transcription factor present on chr13, interacting with many septal defects link genes.

10. Low FOXO1 expression is associated with insulin-resistant state of type 2 diabetes.

11. expression significantly deceased in degenerated discs

12. the key role of the HDAC9-FoxO1 signalling axis in regulating gluconeogenic genes, transcriptional factors, gluconeogenesis metabolism, and HCV-induced gluconeogenesis in hepatocytes.

13. Glucosamine affects signaling pathway activation of NK-92 immune cells, changing the phosphorylation of FOXO1, paxillin, and the ERK map kinase pathway

14. results indicate that FOXO1 is downregulated by miR300 in hepatocellular carcinoma (HCC) cells and that FOXO1 mediates miR300induced cell viability.

15. Loss of FOXO1 protein is identified as an early event during pancreatic ductal adenocarcinoma development and may be independent of the top 4 mutated cancer genes

16. The cardiac regeneration may be promoted by proper control of FOXO1/3 activity. FOXO1 mainly plays a detrimental role in heart while FOXO3's actions are influenced by cell type. [review]

17. Data show that long non-coding RNA MALAT1 (MALAT1) repressed sirtuin 1 (SIRT1) expression through targeting forkhead box protein O1 (Foxo1).

18. Authors showed that up-regulation of FOXO1 in cardiomyocytes is central in the pathogenesis of CIH-induced cardiac hypertrophy.

19. Elatoside C (EsC) attenuated ox-LDL-induced HUVECs injury by inducing autophagy via increasing FoxO1 expression level. EsC is thus considered as a potential drug for the treatment of atherosclerosis.

20. MiR-145 could suppress human adipose-derived mesenchymal stem cells osteoinductive differentiation by suppressing FoxO1 directly.

Zebrafish Forkhead Box O1 (FOXO1) interaction partners

1. The findings reveal a novel mechanism by which Ca2+ overload disrupts myofibril integrity by activating a Calcineurin-FoxO-MuRF1-proteosome signaling pathway.

2. These results indicate that miR-182 functions as a FoxO1 inhibitor to antagonize osteoblast proliferation and differentiation, with a subsequent negative effect on osteogenesis.

3. gas6 protects endothelial cells from apoptosis by a mechanism that involves PI3K-Akt-dependent inactivation of FOXO1a.

Mouse (Murine) Forkhead Box O1 (FOXO1) interaction partners

1. These results indicate that liver FoxO1 promotes serpinB1 expression in hepatic insulin resistance and that non-cell-autonomous factors contribute to FoxO1-dependent effects on serpinB1 expression in the liver.

2. FOXO1 is continuously required for all the phenotypic characteristics of memory-effector T cells such that with acute inactivation of the gene encoding FOXO1, T cells revert to a short-lived effector phenotype, exhibit reduced viability, and manifest characteristics of anergy.

3. FOXO1 s involved in establishing endothelial tip cell polarity during sprouting angiogenesis.MST1 regulates FOXO1 localization at tip endothelial cells.

4. the CAR-Akt-Foxo1 signalling pathway has an essential role in controlling hepatocyte proliferation by repressing the cell cycle regulator Cdkn1a (p21)

5. these findings reveal the pivotal role of FoxO1 in controlling endothelial metabolic and angiogenic adaptations in response to high-fat diet.

6. Cep55 overexpression causes male-specific sterility in mice by suppressing Foxo1 nuclear retention

7. Low FOXO1 expression is associated with cancer.

8. Results demonstrate that the timing of FOXO1 activation affects its role in pituitary gland organogenesis and somatotrope differentiation.

9. High Foxo1 expression is associated with cardiac dysfunction.

10. Demonstrate that the transcription factor Forkhead Box O1 (FOXO1) is a critical regulator of endometrial receptivity in vivo. Uterine ablation of Foxo1 using the progesterone receptor Cre (PgrCre) model resulted in infertility due to altered epithelial cell polarity and apoptosis, preventing the embryo from penetrating the luminal epithelium.

11. The results together illustrated that as a major regulator in redox homeostasis and osteoblast physiology, FoxO1 provides a favorable intracellular environment for osteoblast functions by defensing against the adverse effects of oxidative stress.

12. CD226 regulation of NK cell cytotoxicity is facilitated through inactivation of FOXO1. Gene-expression analysis of NK cells isolated from syngeneic tumors grown in wild-type or CD226-deficient mice revealed dysregulated expression of FOXO1-regulated genes in the absence of CD226.

13. The results indicate that chondrocytes play a prominent role in diabetes-impaired fracture healing and that high levels of glucose, AGEs, and tumor necrosis factor-alpha, which are elevated by diabetes, alter RANKL expression in chondrocytes via FOXO1.

14. expression in lumbar intervertebral discs decreased with aging

15. Exosomes derived from pancreatic cancer cells induce insulin resistance in C2C12 myotube cells through the Pik3cd/Akt/FoxO1 pathway.

16. FOXO transcription factors play a salutary role in the protection against the diet-induced fatty liver disease.

17. Furthermore, chromatin immunoprecipitation (ChIP) followed by luciferase assays revealed direct binding of Foxo1 to both the Il9 and Irf4 promoters and induces their transactivation.

18. Japanese encephalitis virus (JEV) induced cell apoptosis by inhibiting STAT3-Foxo-Bcl-6/p21 pathway, which provides a novel insight into JEV-caused encephalitis.

19. data reveal the pervasive role of forkhead box O1(FoxO1) in mediating the effects of insulin on not only glucose metabolism but also other hormonal signaling pathways and even some aspects of lipid metabolism

20. FOXO1 deletion in epithelium led to impaired healing that included decreased formation of new connective tissue.

Pig (Porcine) Forkhead Box O1 (FOXO1) interaction partners

1. FOXO1-suppressed miR-424 regulates both the proliferation and osteogenic differentiation of mesenchymal stem cells via targeting FGF2.

2. Studied the effects of microRNA-27a on myogenin expression and the Akt/FoxO1 signal pathway during porcine myoblast differentiation. Overexpression of miR-27a suppressed myogenin expression during porcine myoblast differentiation, whereas inhibition of miR-27a promoted the mRNA and protein expression levels of myogenin; overexpression of miR-27a decreased the level of P-Akt/Akt and increased the protein level of FoxO1.

3. he knockdown of FoxO1 repressed lipogenesis by downregulating PDGFRalpha, and miR-34a inhibited adipogenesis through targeting PDGFRalpha.

4. These results indicate glycine enhances muscle protein mass under an inflammatory condition. The beneficial roles of glycine on the muscle are closely associated with maintaining Akt-mTOR-FOXO1 signaling and suppressing the activation of TLR4 and/or NOD2 signaling pathways.

5. let-7g induces porcine granulosa cells apoptosis by inhibiting the MAP3K1 gene, which promotes FoxO1 expression and dephosphorylation with nuclear accumulation.

6. inhibition of FoxO1 expression level caused by miR-15a/b over-expression had a positive effect on adipogenesis. Thus, we conclude that miR-15a/b promote adipogenesis in porcine pre-adipocyte via repressing FoxO1

7. Results show that FoxO1 likely regulates MyHC I negatively and MyHC IIx and MyHC IIb positively and may play a pivotal role in the determination of muscle fiber type.

8. Data suggest forkhead box protein O1 (FoxO1) involvement in the regulation of TNF-related apoptosis-inducing ligand TRAIL and Fas ligand FasL expression during follicular atresia.

9. Data show that IL-4 induces upregulation of the junction protein claudin-5 in endothelial cells (ECs) through activation of Jak/STAT6 and phosphorylation and translocation of FoxO1 from the nucleus to the cytoplasm.

10. FoxO1 and C/EBPb regulate preadipocyte adipogenesis possibly through C/EBPb-> FoxO1-> C/EBPb feedback regulatory loop and FoxO1-C/EBPb protein complex.

11. FoxO1 delays and negatively regulates the porcine myoblast differentiation. It may also play a critical role in muscle fiber-type specification through the inhibition of myogenic regulation factors.

12. concluded that PI 3-kinase and Akt are activated after renal ischemia/reperfusion and that Akt phosphorylation leads to phosphorylation of FKHR and FKHRL1, which may affect epithelial cell fate in acute renal failure.

13. FoxO1a can regulate p27kip nuclear localization

14. FoxO1 expression level has a negative correlation with the development of muscle fiber

15. results suggested that porcine FoxO1 gene took part in the regulation of adipose and was a negative transcription regulation factor in preadipocyte differentiation

Cow (Bovine) Forkhead Box O1 (FOXO1) interaction partners

1. This is the first study demonstrating a role for AMPK-SIRT1-FOXO1 signalling pathway in regulating apoptosis in bovine intramuscular adipocytes.

2. MicroRNA-183-96-182 cluster regulates bovine granulosa cell function by targeting FOXO1 gene.

3. downregulation of SIRT1 and FoxO1 were observed in the backfat tissue of Lilu cattle with increasing age

4. Animals with genotype AA at SNP A176183G in FOX01 had significantly greater body length, chest breadth and chest depth than those with genotypes AG and GG.

5. FOXO is a key regulator of ROS-induced apoptosis in mammalian cells.

6. Protein kinase A-alpha directly phosphorylates FoxO1 in vascular endothelial cells to regulate expression of vascular cellular adhesion molecule-1 mRNA.

7. The results demonstrate pathways through which two different mediators, TNF-alpha and an advanced glycation endproduct, can induce pericyte apoptosis through activation of the transcription factor FOXO1.

Rhesus Monkey Forkhead Box O1 (FOXO1) interaction partners

1. FOXO1, 3, and 4 as well as their upstream regulator, AKT/p-AKT, was examined in rhesus macaque ovaries of three developmental stages: fetal, prepubertal, and adult

Xenopus laevis Forkhead Box O1 (FOXO1) interaction partners

1. FoxO1 translocation to the nucleus, and the increase in FoxO1 DNA binding activity in X. laevis liver strongly correlate with the up-regulation of manganese-dependent superoxide dismutase and catalase mRNA and protein levels in this organ.