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anti-Human FOXO1 Antibodies:
anti-Rat (Rattus) FOXO1 Antibodies:
anti-Mouse (Murine) FOXO1 Antibodies:
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Human Polyclonal FOXO1 Primary Antibody for ICC, IF - ABIN250693
Hoekstra, Sefton, Berry, Lu, Hardt, Marsh, Yin, Clardy, Chakravarti, Bulun, Kim: Progestins activate the AKT pathway in leiomyoma cells and promote survival. in The Journal of clinical endocrinology and metabolism 2009
Show all 8 Pubmed References
Human Polyclonal FOXO1 Primary Antibody for IHC - ABIN966149
Zhao, Gan, Pan, Kan, Majeski, Adam, Unterman: Multiple elements regulate nuclear/cytoplasmic shuttling of FOXO1: characterization of phosphorylation- and 14-3-3-dependent and -independent mechanisms. in The Biochemical journal 2004
Show all 4 Pubmed References
Human Polyclonal FOXO1 Primary Antibody for IF, IHC - ABIN362088
Zhan, Wang, Li, Xu, Sun, Xu: Activation of Akt/FoxO signaling pathway contributes to induction of neuroprotection against transient global cerebral ischemia by hypoxic pre-conditioning in adult rats. in Journal of neurochemistry 2010
Show all 3 Pubmed References
Human Polyclonal FOXO1 Primary Antibody for IHC (fro), IF - ABIN4948288
Sajan, Ivey, Lee, Mastorides, Jurczak, Samuels, Shulman, Braun, Leitges, Farese: PKC? haploinsufficiency prevents diabetes by a mechanism involving alterations in hepatic enzymes. in Molecular endocrinology (Baltimore, Md.) 2014
Show all 3 Pubmed References
Human Polyclonal FOXO1 Primary Antibody for ICC, IF - ABIN4312363
Sahu, Laakso, Ovaska, Mirtti, Lundin, Rannikko, Sankila, Turunen, Lundin, Konsti, Vesterinen, Nordling, Kallioniemi, Hautaniemi, Jänne: Dual role of FoxA1 in androgen receptor binding to chromatin, androgen signalling and prostate cancer. in The EMBO journal 2011
Show all 2 Pubmed References
Human Monoclonal FOXO1 Primary Antibody for ICC, IHC - ABIN969521
Lau, Koty, Nalbantoglu: Differential response of glioma cells to FOXO1-directed therapy. in Cancer research 2009
Show all 2 Pubmed References
Human Polyclonal FOXO1 Primary Antibody for IHC - ABIN966148
Gan, Zheng, Chabot, Unterman, Quirion: Nuclear/cytoplasmic shuttling of the transcription factor FoxO1 is regulated by neurotrophic factors. in Journal of neurochemistry 2005
Show all 2 Pubmed References
Human Polyclonal FOXO1 Primary Antibody for ELISA, WB - ABIN252951
Paik, Kollipara, Chu, Ji, Xiao, Ding, Miao, Tothova, Horner, Carrasco, Jiang, Gilliland, Chin, Wong, Castrillon, DePinho: FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. in Cell 2007
Human Polyclonal FOXO1 Primary Antibody for IF, IHC - ABIN362738
Smith, Norton, Gorospe, Jiang, Nemoto, Holbrook, Finkel, Kusiak: Phosphorylation of p66Shc and forkhead proteins mediates Abeta toxicity. in The Journal of cell biology 2005
Show all 6 Pubmed References
Cow (Bovine) Polyclonal FOXO1 Primary Antibody for WB - ABIN2780391
Okamoto, Hribal, Lin, Bennett, Ward, Accili: Role of the forkhead protein FoxO1 in beta cell compensation to insulin resistance. in The Journal of clinical investigation 2006
Show all 2 Pubmed References
MicroRNA-183-96-182 cluster regulates bovine granulosa cell function by targeting FOXO1 gene.
downregulation of SIRT1 (show SIRT1 Antibodies) and FoxO1 were observed in the backfat tissue of Lilu cattle with increasing age
FOXO (show FOXO3 Antibodies) is a key regulator of ROS (show ROS1 Antibodies)-induced apoptosis in mammalian cells.
Protein kinase A-alpha directly phosphorylates FoxO1 in vascular endothelial cells to regulate expression of vascular cellular adhesion molecule (show NCAM1 Antibodies)-1 mRNA.
The results demonstrate pathways through which two different mediators, TNF-alpha (show TNF Antibodies) and an advanced glycation endproduct, can induce pericyte apoptosis through activation of the transcription factor FOXO1.
These data suggest that high doses of insulin (show INS Antibodies) downregulate apoA-I (show APOA1 Antibodies) gene expression in HepG2 cells through redistribution of FOXO1/LXRbeta (show NR1H2 Antibodies) complex, FOXA2 (show FOXA2 Antibodies), and LXRalpha (show NR1H3 Antibodies) on hepatic enhancer of apoA-I (show APOA1 Antibodies) gene.
FOXO1 inhibits the self-renewal capacity of gastric cancer cells through interaction with LGR5 (show LGR5 Antibodies).
elevated expression of microRNA-873 facilitates Th17 differentiation by targeting forkhead box O1 (Foxo1) in the pathogenesis of systemic lupus erythematosus
Results provide a mechanistic understanding for the observation that loss of IGF-1R (show IGF1R Antibodies) expression decreases tamoxifen sensitivity resulting from reduced FoxO1 expression in breast cancer cells.
Low FOXO1 expression is associated with invasive oral cancer.
TLR4 (show TLR4 Antibodies) and C5aR (show C5AR1 Antibodies) crosstalk in dendritic cells induces a core regulatory network of RSK2 (show RPS6KA3 Antibodies), PI3Kbeta, SGK1 (show SGK1 Antibodies), and FOXO (show FOXO3 Antibodies) transcription factors.
The data suggest that pre-B cells are endowed with a protective mechanism that reduces the risk for aberrant recombinations and chromosomal translocations when exposed to DNA damage, involving the ATM (show ATM Antibodies)-dependent regulation of FOXO1 binding to the Erag enhancer region.
expression of Bim (show BCL2L11 Antibodies) is mediated by FoxO1 and indirectly downregulated by thyroid hormone/thyroid hormone (show PTH Antibodies) receptor (show THRA Antibodies), leading to chemotherapy resistance and doxorubicin-promoted metastasis of hepatoma cells.
this study shows that FoxO1 plays an important role in regulating asbestos-induced apoptosis in T cells
increased FOXO1 represents a critical mechanism driving aberrant self-renewal in preleukemic cells expressing the t(8;21)-associated oncogene AML1 (show RUNX1 Antibodies)-ETO (show RUNX1T1 Antibodies).
These results indicate glycine enhances muscle protein mass under an inflammatory condition. The beneficial roles of glycine on the muscle are closely associated with maintaining Akt (show AKT1 Antibodies)-mTOR (show FRAP1 Antibodies)-FOXO1 signaling and suppressing the activation of TLR4 (show TLR4 Antibodies) and/or NOD2 (show NOD2 Antibodies) signaling pathways.
let-7g induces porcine granulosa cells apoptosis by inhibiting the MAP3K1 (show MAP3K1 Antibodies) gene, which promotes FoxO1 expression and dephosphorylation with nuclear accumulation.
inhibition of FoxO1 expression level caused by miR (show MYLIP Antibodies)-15a/b over-expression had a positive effect on adipogenesis. Thus, we conclude that miR (show MYLIP Antibodies)-15a/b promote adipogenesis in porcine pre-adipocyte via repressing FoxO1
Results show that FoxO1 likely regulates MyHC I (show MYH7 Antibodies) negatively and MyHC IIx and MyHC IIb (show MYH4 Antibodies) positively and may play a pivotal role in the determination of muscle fiber type.
Data suggest forkhead box protein O1 (FoxO1) involvement in the regulation of TNF-related apoptosis-inducing ligand TRAIL (show TNFSF10 Antibodies) and Fas ligand FasL (show FASL Antibodies) expression during follicular atresia.
Data show that IL-4 (show IL4 Antibodies) induces upregulation of the junction protein claudin-5 (show CLDN5 Antibodies) in endothelial cells (ECs) through activation of Jak (show JAK3 Antibodies)/STAT6 (show STAT6 Antibodies) and phosphorylation and translocation of FoxO1 from the nucleus to the cytoplasm.
FoxO1 and C/EBPb (show CEBPB Antibodies) regulate preadipocyte adipogenesis possibly through C/EBPb (show CEBPB Antibodies)-> FoxO1-> C/EBPb (show CEBPB Antibodies) feedback regulatory loop and FoxO1-C/EBPb (show CEBPB Antibodies) protein complex.
FoxO1 delays and negatively regulates the porcine myoblast differentiation. It may also play a critical role in muscle fiber-type specification through the inhibition of myogenic regulation factors.
concluded that PI 3 (show PI3 Antibodies)-kinase and Akt (show AKT1 Antibodies) are activated after renal ischemia/reperfusion and that Akt (show AKT1 Antibodies) phosphorylation leads to phosphorylation of FKHR and FKHRL1 (show FOXO3 Antibodies), which may affect epithelial cell fate in acute renal failure.
FoxO1a can regulate p27kip nuclear localization
data reveal apelin (show APLN Antibodies) as a novel regulator of FoxO1 in cardiac cells and provide evidence for the potential of apelin (show APLN Antibodies)-13 in prevention of apoptosis and mitochondrial damage in conditions combining I/R injury and obesity.
Besides, both in vivo and in votro studies suggested that K145 stimulated insulin (show INS Antibodies) dependent Akt (show AKT1 Antibodies) phosphorylation and subsequently activates FoxO1 phosphorylation therefore inhibited gluconeogenetic genes expression including PEPCK (show PEPCK Antibodies) and G6pase (show G6PC Antibodies). Our study figures out a potential extent increase the value of developing K145 as therapeutic candidate for diabetes.
Ikaros (show IKZF1 Antibodies) is a transcriptional regulator required for maintaining levels of Foxo1 gene expression in naive T-cells.
this study shows that Foxo1 is a positive regulatory factor for the proliferation and activity of Treg cells
Data show that Fos-Related Antigen-2 (Fra-2 (show FOSL2 Antibodies)) is a key upstream regulator of forkhead box O1 (Foxo1) and interferon regulatory factor 4 (Irf4 (show IRF4 Antibodies)) expression and influences proliferation and differentiation of B cells at multiple stages.
ANG2 (show ANGPT2 Antibodies) activation of Tie2 (show TEK Antibodies) supports stable enlargement of normal nonleaky vessels, but reduction of Tie1 (show TIE1 Antibodies) in inflammation leads to ANG2 (show ANGPT2 Antibodies) antagonism of Tie2 (show TEK Antibodies) and initiates a positive feedback loop wherein FOXO1-driven ANG2 (show ANGPT2 Antibodies) expression promotes vascular remodeling and leakage
Link between the antioxidative activity of FoxO1 with PINK1 (show PINK1 Antibodies)/Parkin (show PARK2 Antibodies)-induced mitophagy, indicating a novel role of FoxO1 in diabetic nephropathy.
Pyruvate dehydrogenase kinase 4 (show PDK4 Antibodies) is a direct transcriptional target of FoxO1 in the heart. FoxO1 directly regulates Pdk4 (show PDK4 Antibodies) transcription in the heart, thereby controlling PDH (show PDP Antibodies) activity and subsequent glucose oxidation rates.
the overlap of IR and IGF1R (show IGF1R Antibodies) signaling is critical to the regulation of muscle protein turnover, and this regulation depends on suppression of FoxO (show FOXO3 Antibodies)-regulated, autophagy-mediated protein degradation
These results suggest that the LKB1 (show STK11 Antibodies)-AMPK (show PRKAA1 Antibodies)-FoxO1 signaling pathway is a critical mediator of the antioxidant properties of H2, further supporting the idea that H2 acts as a signaling molecule to serve various physiological functions.
FoxO1 translocation to the nucleus, and the increase in FoxO1 DNA binding activity in X. laevis liver strongly correlate with the up-regulation of manganese-dependent superoxide dismutase (show SOD1 Antibodies) and catalase (show CAT Antibodies) mRNA and protein levels in this organ.
These results indicate that miR (show MYLIP Antibodies)-182 functions as a FoxO1 inhibitor to antagonize osteoblast proliferation and differentiation, with a subsequent negative effect on osteogenesis.
gas6 (show GAS6 Antibodies) protects endothelial cells from apoptosis by a mechanism that involves PI3K-Akt (show AKT1 Antibodies)-dependent inactivation of FOXO1a.
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined\; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma.
forkhead box protein O1
, forkhead box protein O1A
, forkhead, Drosophila, homolog of, in rhabdomyosarcoma
, forkhead box O1A
, forkhead box protein O1-A
, fox family transcription factor FoxO1a.1
, foxhead box protein O1-A
, Forkhead box protein O1A
, Forkhead in rhabdomyosarcoma
, forkhead box O1A (rhabdomyosarcoma)
, forkhead box O1a
, forkhead in rhabdomyosarcoma
, forkhead protein 1
, forkhead/winged helix transcription factor FOXO1a
, forkhead box O1
, forkhead box protein O1-like