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results indicate that FOXO1 inhibits gastric cancer (GC) growth and angiogenesis under hypoxic conditions via inactivation of the HIF-1alpha (show HIF1A Proteins)-VEGF (show VEGFA Proteins) pathway, possibly in association with SIRT1 (show SIRT1 Proteins); thus, development of treatment modalities aiming at this pathway might be useful for treating GC
These results suggest that liraglutide may exert a renoprotective effect by a FoxO1-mediated upregulation of renal MnSOD (show SOD2 Proteins) expression in the early DKD.
FOXO1, acetylation of FOXO1 and the following interaction between Ac-FOXO1 and Atg7 regulated the basal and serum starvation induced autophagy as evidenced by light chain 3 (LC3) accumulation and p62 degration.
PAX3 (show PAX3 Proteins)-FOXO1 fusion protein serves as a driver mutation to initiate a cascade of mRNA and miRNA changes that ultimately reprogram proliferating myoblasts to induce the formation of alveolar rhabdomyosarcoma
Induced the nuclear accumulation of FOXO1.
The data indicate that Akt2 (show AKT2 Proteins) ablation protects against cardiac aging through restored Foxo1-related autophagy and mitochondrial integrity.
the present study demonstrated that the expression of miR (show MLXIP Proteins)-196a in human liver cancer cells was upregulated; downregulation of miR (show MLXIP Proteins)-196a regulated human liver cancer cell biological functions which could benefit the clinical therapy of human liver cancer in the future
Inhibition of FOXO1 enhanced angiogenesis in human bio-engineered capillaries, and resulted in microvascular regeneration and improved function in mouse models of injury-repair.
Cells harboring the fusion gene are selectively sensitive to small-molecule inhibition of protein targets induced by, or bound to, PAX3 (show PAX3 Proteins)-FOXO1-occupied super enhancers. Furthermore, PAX3 (show PAX3 Proteins)-FOXO1 recruits and requires the BET bromodomain protein BRD4 (show BRD4 Proteins) to function at super enhancers, resulting in a complete dependence on BRD4 (show BRD4 Proteins) and a significant susceptibility to BRD inhibition
FOXO1 silencing also augmented the migratory behavior of SW-13 cells (p<0.0001), suggesting distinct roles for FOXO1 in promoting viability and controlled motility of adrenocortical cells.
The findings reveal a novel mechanism by which Ca2 (show CA2 Proteins)+ overload disrupts myofibril integrity by activating a Calcineurin-FoxO (show FOXO3 Proteins)-MuRF1 (show TRIM63 Proteins)-proteosome signaling pathway.
These results indicate that miR (show MYLIP Proteins)-182 functions as a FoxO1 inhibitor to antagonize osteoblast proliferation and differentiation, with a subsequent negative effect on osteogenesis.
gas6 (show GAS6 Proteins) protects endothelial cells from apoptosis by a mechanism that involves PI3K-Akt (show AKT1 Proteins)-dependent inactivation of FOXO1a.
FOXO1 is dispensable for naive T cell expression of TCF7 (show TCF7 Proteins), it is essential for the expression of TCF7 (show TCF7 Proteins) in a small subset of T cells within days following primary infection.
Foxo1 expression compromised embryonic stem cell self-renewal
we identified that Sirtuin 1 (SIRT1 (show SIRT1 Proteins)), a deacetylase that suppresses FoxO1 acetylation in granulosa cell (GCs (show UGCG Proteins)), was downregulated by miR (show MLXIP Proteins)-181a and reversed the promoting effects of H2O2 and miR (show MLXIP Proteins)-181a on FoxO1 acetylation and GC apoptosis.
Study identified the roles of Foxo1 as a positive regulator and Foxp1 as a negative regulator of TH9 cell differentiation and antitumor activity.
miR (show MLXIP Proteins)-150-mediated suppression of Foxo1 regulates the balance between effector and memory cell differentiation
Authors found that the repress effect of alphaMSH (show POMC Proteins) in adipocytes apoptosis is acting through Foxo1/mTORC2 (show CRTC2 Proteins) pathway. These findings indicate that, alphaMSH (show POMC Proteins) has a strong inhibitory effect on ROS (show ROS1 Proteins)-induced adipocyte apoptosis and underlying mechanism is interacting with key factors in mTOR (show FRAP1 Proteins) signal pathway.
Sirt3 (show SIRT3 Proteins) activation is essential to improve autophagy flux by reducing the acetylation modification on FoxO1, which in turn alleviates myocardial hypertrophy.
The data reveal a novel mechanism in which the elevated miR (show MLXIP Proteins)-425 in IBD mediates pathogenic Th17 cell generation through down-regulation of Foxo1.
we found that in db/db (show LEPR Proteins) VSMC, the occupancy in promoter regions of inflammatory genes by FOXO1 was reduced.miR-135a increased the inflammatory responses of VSMC involved in complications of vascular diseases by downregulating the expression of FOXO1.
he knockdown of FoxO1 repressed lipogenesis by downregulating PDGFRalpha, and miR (show MYLIP Proteins)-34a inhibited adipogenesis through targeting PDGFRalpha.
These results indicate glycine enhances muscle protein mass under an inflammatory condition. The beneficial roles of glycine on the muscle are closely associated with maintaining Akt-mTOR-FOXO1 signaling and suppressing the activation of TLR4 and/or NOD2 signaling pathways.
let-7g induces porcine granulosa cells apoptosis by inhibiting the MAP3K1 (show MAP3K1 Proteins) gene, which promotes FoxO1 expression and dephosphorylation with nuclear accumulation.
inhibition of FoxO1 expression level caused by miR (show MYLIP Proteins)-15a/b over-expression had a positive effect on adipogenesis. Thus, we conclude that miR (show MYLIP Proteins)-15a/b promote adipogenesis in porcine pre-adipocyte via repressing FoxO1
Results show that FoxO1 likely regulates MyHC I (show MYH7 Proteins) negatively and MyHC IIx and MyHC IIb (show MYH4 Proteins) positively and may play a pivotal role in the determination of muscle fiber type.
Data suggest forkhead box protein O1 (FoxO1) involvement in the regulation of TNF-related apoptosis-inducing ligand TRAIL (show TNFSF10 Proteins) and Fas ligand FasL (show FASL Proteins) expression during follicular atresia.
Data show that IL-4 (show IL4 Proteins) induces upregulation of the junction protein claudin-5 (show CLDN5 Proteins) in endothelial cells (ECs) through activation of Jak (show JAK3 Proteins)/STAT6 (show STAT6 Proteins) and phosphorylation and translocation of FoxO1 from the nucleus to the cytoplasm.
FoxO1 and C/EBPb (show CEBPB Proteins) regulate preadipocyte adipogenesis possibly through C/EBPb (show CEBPB Proteins)-> FoxO1-> C/EBPb (show CEBPB Proteins) feedback regulatory loop and FoxO1-C/EBPb (show CEBPB Proteins) protein complex.
FoxO1 delays and negatively regulates the porcine myoblast differentiation. It may also play a critical role in muscle fiber-type specification through the inhibition of myogenic regulation factors.
concluded that PI 3 (show PI3 Proteins)-kinase and Akt (show AKT1 Proteins) are activated after renal ischemia/reperfusion and that Akt (show AKT1 Proteins) phosphorylation leads to phosphorylation of FKHR and FKHRL1 (show FOXO3 Proteins), which may affect epithelial cell fate in acute renal failure.
MicroRNA-183-96-182 cluster regulates bovine granulosa cell function by targeting FOXO1 gene.
downregulation of SIRT1 (show SIRT1 Proteins) and FoxO1 were observed in the backfat tissue of Lilu cattle with increasing age
FOXO (show FOXO3 Proteins) is a key regulator of ROS (show ROS1 Proteins)-induced apoptosis in mammalian cells.
Protein kinase A-alpha directly phosphorylates FoxO1 in vascular endothelial cells to regulate expression of vascular cellular adhesion molecule (show NCAM1 Proteins)-1 mRNA.
The results demonstrate pathways through which two different mediators, TNF-alpha (show TNF Proteins) and an advanced glycation endproduct, can induce pericyte apoptosis through activation of the transcription factor FOXO1.
FOXO1, 3, and 4 as well as their upstream regulator, AKT/p-AKT (show AKT1 Proteins), was examined in rhesus macaque ovaries of three developmental stages: fetal, prepubertal, and adult
FoxO1 translocation to the nucleus, and the increase in FoxO1 DNA binding activity in X. laevis liver strongly correlate with the up-regulation of manganese-dependent superoxide dismutase (show SOD1 Proteins) and catalase (show CAT Proteins) mRNA and protein levels in this organ.
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined\; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma.
forkhead box protein O1
, forkhead box protein O1A
, forkhead, Drosophila, homolog of, in rhabdomyosarcoma
, forkhead box O1A
, forkhead box protein O1-A
, fox family transcription factor FoxO1a.1
, foxhead box protein O1-A
, Forkhead box protein O1A
, Forkhead in rhabdomyosarcoma
, forkhead box O1A (rhabdomyosarcoma)
, forkhead box O1a
, forkhead in rhabdomyosarcoma
, forkhead protein 1
, forkhead/winged helix transcription factor FOXO1a
, forkhead box O1
, forkhead box protein O1-like