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This study is the first to demonstrate FOXO1 gene rearrangements in malignant ectomesenchymoma with alveolar rhabdomyosarcoma subtype.
The HIF1alphainduced expression of Runx2 (show RUNX2 Proteins) and ALP (show ALP Proteins) may be completely dependent on the expression levels of Foxo1, and in turn, osteocalcin (show BGLAP Proteins) may be partially dependent on Foxo1 expression.
A novel role of FoxO1 inhibition in promoting IPC differentiation of hESCs.
FOXO1 overexpression increased the length of the microvilli on the cell surface, whereas FOXO1 silencing significantly reduced their length.
High FOXO1 expression is associated with prostatic cancer.
FOXO1 serves as an important linker between HER2 (show ERBB2 Proteins) and MET signaling pathways through negative crosstalks and is a key regulator of the acquired lapatinib resistance in HER2 (show ERBB2 Proteins)-positive GC cells.
LncRNA DANCR could inhibit osteoblast differentiation by regulating FOXO1 expression.
A significant correlation between the physical activity level and peripheral blood mononuclear cell SIRT1 (show SIRT1 Proteins) and FOXO1 mRNA expression was found in COPD (show ARCN1 Proteins) patients.
results indicate that FOXO1 inhibits gastric cancer (GC) growth and angiogenesis under hypoxic conditions via inactivation of the HIF-1alpha (show HIF1A Proteins)-VEGF (show VEGFA Proteins) pathway, possibly in association with SIRT1 (show SIRT1 Proteins); thus, development of treatment modalities aiming at this pathway might be useful for treating GC
These results suggest that liraglutide may exert a renoprotective effect by a FoxO1-mediated upregulation of renal MnSOD (show SOD2 Proteins) expression in the early DKD.
The findings reveal a novel mechanism by which Ca2 (show CA2 Proteins)+ overload disrupts myofibril integrity by activating a Calcineurin-FoxO (show FOXO3 Proteins)-MuRF1 (show TRIM63 Proteins)-proteosome signaling pathway.
These results indicate that miR (show MYLIP Proteins)-182 functions as a FoxO1 inhibitor to antagonize osteoblast proliferation and differentiation, with a subsequent negative effect on osteogenesis.
gas6 (show GAS6 Proteins) protects endothelial cells from apoptosis by a mechanism that involves PI3K-Akt (show AKT1 Proteins)-dependent inactivation of FOXO1a.
the results of the present study suggest that moderate overexpression of SIRT1 (~3fold of normal level) may directly or indirectly inhibit apoptosis of OBs via the FOXO1 and betacatenin signaling pathway.
insulin (show INS Proteins)-activated SREBP1c (show SREBF1 Proteins) downregulates gluconeogenesis through CRY1 (show CRY1 Proteins)-mediated FOXO1 degradation.
Our study demonstrated that Arachidonic acid (AA) inhibits macrophage viability by inducing S phase cell cycle arrest. The JNK (show MAPK8 Proteins) signaling pathway and the downstream FoxO (show FOXO3 Proteins) transcription factors are involved in AA-induced RAW264.7 cell cycle arrest.
the transcription of Rho-associated coiled-coil containing protein kinase 1 (ROCK1 (show ROCK1 Proteins)), which phosphorylates Drp1 (show CRMP1 Proteins) at Ser616, was shown by luciferase assay to be directly regulated by FOXO1. These findings suggested that FOXO1 is critical to preserve mitochondrial quantity and function in ECs, and FOXO1 may serve as a therapeutic target for microvascular complications of diabetes.
Chimeric antigen receptor T cells releasing IL-18 (show IL18 Proteins) convert to T-Bet(high) FoxO1(low) effectors that exhibit augmented activity against advanced solid tumors.
the molecular level, we confirmed, for the first time, that RES upregulated FoxO1 transcriptional activity by inhibiting the PI3K/AKT (show AKT1 Proteins) signaling pathway, and hence promoted resistance to oxidative damage and restrained osteoclastogenesis. Inhibition of the PI3K/AKT (show AKT1 Proteins) signaling pathway may be induced by RANKL (show TNFSF11 Proteins).
FOXO1 is dispensable for naive T cell expression of TCF7 (show TCF7 Proteins), it is essential for the expression of TCF7 (show TCF7 Proteins) in a small subset of T cells within days following primary infection.
Foxo1 expression compromised embryonic stem cell self-renewal
we identified that Sirtuin 1 (SIRT1 (show SIRT1 Proteins)), a deacetylase that suppresses FoxO1 acetylation in granulosa cell (GCs (show UGCG Proteins)), was downregulated by miR (show MLXIP Proteins)-181a and reversed the promoting effects of H2O2 and miR (show MLXIP Proteins)-181a on FoxO1 acetylation and GC apoptosis.
Study identified the roles of Foxo1 as a positive regulator and Foxp1 as a negative regulator of TH9 cell differentiation and antitumor activity.
Studied the effects of microRNA-27a on myogenin (show MYOG Proteins) expression and the Akt (show AKT1 Proteins)/FoxO1 signal pathway during porcine myoblast differentiation. Overexpression of miR (show MYLIP Proteins)-27a suppressed myogenin (show MYOG Proteins) expression during porcine myoblast differentiation, whereas inhibition of miR (show MYLIP Proteins)-27a promoted the mRNA and protein expression levels of myogenin (show MYOG Proteins); overexpression of miR (show MYLIP Proteins)-27a decreased the level of P-Akt/Akt (show AKT1 Proteins) and increased the protein level of FoxO1.
he knockdown of FoxO1 repressed lipogenesis by downregulating PDGFRalpha, and miR (show MYLIP Proteins)-34a inhibited adipogenesis through targeting PDGFRalpha.
These results indicate glycine enhances muscle protein mass under an inflammatory condition. The beneficial roles of glycine on the muscle are closely associated with maintaining Akt-mTOR-FOXO1 signaling and suppressing the activation of TLR4 and/or NOD2 signaling pathways.
let-7g induces porcine granulosa cells apoptosis by inhibiting the MAP3K1 (show MAP3K1 Proteins) gene, which promotes FoxO1 expression and dephosphorylation with nuclear accumulation.
inhibition of FoxO1 expression level caused by miR (show MYLIP Proteins)-15a/b over-expression had a positive effect on adipogenesis. Thus, we conclude that miR (show MYLIP Proteins)-15a/b promote adipogenesis in porcine pre-adipocyte via repressing FoxO1
Results show that FoxO1 likely regulates MyHC I (show MYH7 Proteins) negatively and MyHC IIx and MyHC IIb (show MYH4 Proteins) positively and may play a pivotal role in the determination of muscle fiber type.
Data suggest forkhead box protein O1 (FoxO1) involvement in the regulation of TNF-related apoptosis-inducing ligand TRAIL (show TNFSF10 Proteins) and Fas ligand FasL (show FASL Proteins) expression during follicular atresia.
Data show that IL-4 (show IL4 Proteins) induces upregulation of the junction protein claudin-5 (show CLDN5 Proteins) in endothelial cells (ECs) through activation of Jak (show JAK3 Proteins)/STAT6 (show STAT6 Proteins) and phosphorylation and translocation of FoxO1 from the nucleus to the cytoplasm.
FoxO1 and C/EBPb (show CEBPB Proteins) regulate preadipocyte adipogenesis possibly through C/EBPb (show CEBPB Proteins)-> FoxO1-> C/EBPb (show CEBPB Proteins) feedback regulatory loop and FoxO1-C/EBPb (show CEBPB Proteins) protein complex.
FoxO1 delays and negatively regulates the porcine myoblast differentiation. It may also play a critical role in muscle fiber-type specification through the inhibition of myogenic regulation factors.
This is the first study demonstrating a role for AMPK (show PRKAA1 Proteins)-SIRT1 (show SIRT1 Proteins)-FOXO1 signalling pathway in regulating apoptosis in bovine intramuscular adipocytes.
MicroRNA-183-96-182 cluster regulates bovine granulosa cell function by targeting FOXO1 gene.
downregulation of SIRT1 (show SIRT1 Proteins) and FoxO1 were observed in the backfat tissue of Lilu cattle with increasing age
FOXO (show FOXO3 Proteins) is a key regulator of ROS (show ROS1 Proteins)-induced apoptosis in mammalian cells.
Protein kinase A-alpha directly phosphorylates FoxO1 in vascular endothelial cells to regulate expression of vascular cellular adhesion molecule (show NCAM1 Proteins)-1 mRNA.
The results demonstrate pathways through which two different mediators, TNF-alpha (show TNF Proteins) and an advanced glycation endproduct, can induce pericyte apoptosis through activation of the transcription factor FOXO1.
FOXO1, 3, and 4 as well as their upstream regulator, AKT/p-AKT (show AKT1 Proteins), was examined in rhesus macaque ovaries of three developmental stages: fetal, prepubertal, and adult
FoxO1 translocation to the nucleus, and the increase in FoxO1 DNA binding activity in X. laevis liver strongly correlate with the up-regulation of manganese-dependent superoxide dismutase (show SOD1 Proteins) and catalase (show CAT Proteins) mRNA and protein levels in this organ.
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined\; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma.
forkhead box protein O1
, forkhead box protein O1A
, forkhead, Drosophila, homolog of, in rhabdomyosarcoma
, forkhead box O1A
, forkhead box protein O1-A
, fox family transcription factor FoxO1a.1
, foxhead box protein O1-A
, Forkhead box protein O1A
, Forkhead in rhabdomyosarcoma
, forkhead box O1A (rhabdomyosarcoma)
, forkhead box O1a
, forkhead in rhabdomyosarcoma
, forkhead protein 1
, forkhead/winged helix transcription factor FOXO1a
, forkhead box O1
, forkhead box protein O1-like