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Autophagy regulates c-MET phosphorylation via an mTORC2 (show CRTC2 Proteins)-dependent mechanism.
Data suggest MTMR3 (show MTMR3 Proteins) has multiple functions in regulation of autophagy; one mechanism appears to be direct interaction between MTMR3 (show MTMR3 Proteins) and mTORC1 (MTOR (show FRAP1 Proteins), mLST8, raptor (show RPTOR Proteins)) which inhibits phosphorylation activity of mTORC1; MTMR3 (show MTMR3 Proteins) is localized to Golgi apparatus.
MLST8 upregulation may contribute to tumor progression.
Amino acids promote mTORC1 activation without altering Rag GTP (show AK3 Proteins) charging.
MLST8 polymorphism is associated with gastric cancer.
The results obtained indicate that mLST8 bridges between CAD and mTOR (show FRAP1 Proteins), and plays a role in the signaling mechanism where CAD is regulated in the mTOR (show FRAP1 Proteins) pathway through the association with mLST8.
An essential role of mTORC1 in autophagy inhibition in cell-free system in which, membrane association of Barkor/Atg14(L), a specific autophagosome-binding protein, is suppressed by cytosol from nutrient-rich medium, is shown.
show that E2F1 (show E2F1 Proteins) is capable of inducing growth by regulating mTORC1 activity
Adiponectin induces vascular smooth muscle cell differentiation via repression of mammalian target of rapamycin (show FRAP1 Proteins) complex 1 and FoxO4 (show FOXO4 Proteins)
results suggest that GRp58/ERp57 (show PDIA3 Proteins) is involved in the assembly of mTORC1 and positively regulates mTORC1 signaling at the cytosol and the cytosolic side of the endoplasmic reticulum
the crosstalk between AMPK (show PRKAA1 Proteins) and mTORC1 signaling is a highly regulated way to control changes in muscle growth and metabolic rate imposed by external cues.
The mutant, Gbeta1(W332A) protein, although inactive, retains its ability to bind Kir3 and prevents the wild type Gbeta (show SUCLG2 Proteins) from activating the channel.
cytosolic protein similar to an insulin receptor
Protein LTS8 homolog
, TORC subunit lst8
, protein GbetaL
, target of rapamycin complex subunit lst8
, TORC subunit LST8
, mammalian lethal with SEC13 protein 8
, target of rapamycin complex subunit LST8
, transducin (beta)-like 4
, G beta-like protein