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Mouse (Murine) Polyclonal PPP2CA Primary Antibody for WB - ABIN1881681
Pradhan, Alrehani, Patel, Khatlani, Vijayan: Cross-talk between serine/threonine protein phosphatase 2A and protein tyrosine phosphatase 1B regulates Src activation and adhesion of integrin αIIbβ3 to fibrinogen. in The Journal of biological chemistry 2010
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Monoclonal PPP2CA Primary Antibody for IP, WB - ABIN534113
Kumamoto: A contact-activated kinase signals Candida albicans invasive growth and biofilm development. in Proceedings of the National Academy of Sciences of the United States of America 2005
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Human Monoclonal PPP2CA Primary Antibody for IP, WB - ABIN1042658
Sontag, Nunbhakdi-Craig, Sontag, Diaz-Arrastia, Ogris, Dayal, Lentz, Arning, Bottiglieri: Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and amyloid precursor protein regulation. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2007
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Human Polyclonal PPP2CA Primary Antibody for WB - ABIN1842544
Wu, Reardon, Storey: Effects of hibernation on regulation of mammalian protein phosphatase type-2-A. in Cryobiology 2013
Human Polyclonal PPP2CA Primary Antibody for WB - ABIN363066
Yu, Du, Moreno, Green, Ogris, Feng, Chou, McQuoid, Pallas: Methylation of the protein phosphatase 2A catalytic subunit is essential for association of Balpha regulatory subunit but not SG2NA, striatin, or polyomavirus middle tumor antigen. in Molecular biology of the cell 2001
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Human Polyclonal PPP2CA Primary Antibody for IP, WB - ABIN151684
Yamamoto, Blake-Hodek, Williams, Lewellyn, Goldberg, Maller: Regulation of Greatwall kinase during Xenopus oocyte maturation. in Molecular biology of the cell 2011
Human Polyclonal PPP2CA Primary Antibody for ELISA, WB - ABIN257667
Hemmings, Wernet, Mayer, Maurer, Hofsteenge, Stone: The nucleotide sequence of the cDNA encoding the human lung protein phosphatase 2A beta catalytic subunit. in Nucleic acids research 1989
Polyclonal PPP2CA Primary Antibody for IF, IHC (p) - ABIN540565
Jones, Barker, da Cruz e Silva, Mayer-Jaekel, Hemmings, Spurr, Sheer, Cohen: Localization of the genes encoding the catalytic subunits of protein phosphatase 2A to human chromosome bands 5q23-->q31 and 8p12-->p11.2, respectively. in Cytogenetics and cell genetics 1993
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High PP2A (show PPP2R4 Antibodies) expression is associated with Colorectal Cancer Cell Invasiveness.
PP2A (show PPP2R4 Antibodies) overexpression is associated with lung metastasis in colorectal cancer .
Suspension survival mediated by PP2A (show PPP2R4 Antibodies)-STAT3 (show STAT3 Antibodies)-Col (show HDAC1 Antibodies) XVII determines tumor initiation and metastasis in cancer stem cells.
alpha-Syn bound to PP2A (show PPP2R4 Antibodies) Calpha (show PRKACA Antibodies) by the hydrophobic interaction and upregulated its activity. Blocking the hydrophobic domain of alpha-Syn or hydrophilic mutation on the residue I123 in PP2A (show PPP2R4 Antibodies) Calpha (show PRKACA Antibodies) all reduced PP2A (show PPP2R4 Antibodies) activity upregulation by alpha-Syn.
The results showed SNPs near PPP2CA were associated with decreased expression of PPP2CA mRNA in PBMCs from patients with SLE and suggested that the mRNA expression of the gene may be correlated with the pathogenesis of SLE.
This study demonstrated an association of PPP2CA (rs10491322 and rs7704116) with systemic lupus erythematosus susceptibility in a Chinese Han population. Furthermore, the minor allele of PPP2CA rs10491322 as a risk factor was correlated with immunologic disorders for systemic lupus erythematosus.
RAB9 (show RAB9A Antibodies) competes with the catalytic subunit PPP2CA in binding to PPP2R1A (show PPP2R1A Antibodies). This competitive association has an important role in controlling the PP2A (show PPP2R4 Antibodies) catalytic activity.
Results show that miR (show MLXIP Antibodies)-199b is a tumor suppressor emerges as a potential contributing mechanism to inhibit PP2A (show PPP2R4 Antibodies) via PP2A (show PPP2R4 Antibodies) inhibitor SET (SET) overexpression in metastatic colorectal cancer (mCRC).
Data show that protein phosphatase-2A (PP2A (show PPP2R4 Antibodies)) was upregulated in lung adenocarcinoma cell lines that were transfected with midline 1 (show MID1 Antibodies) E3 ubiquitin-protein ligase (show UBE2K Antibodies) (MID1 (show MID1 Antibodies))-siRNA, suggesting MID1 (show MID1 Antibodies) negatively regulates PP2A (show PPP2R4 Antibodies) in lung adenocarcinoma.
B55alpha (show PPP2R2A Antibodies)-PP2A (show PPP2R4 Antibodies) mutations in acute myeloid leukemia (show BCL11A Antibodies) have roles in leukemogenesis by promoting AKT (show AKT1 Antibodies) T308 phosphorylation and sensitivity to AKT (show AKT1 Antibodies) inhibitor-induced growth arrest
Results indicate that Dlx5 (show DLX5 Antibodies) and Runx2 (show RUNX2 Antibodies) are critical factors for the upregulated Osterix (show SP7 Antibodies) expression in shPP2A cells, which is considered to be important for the accelerated osteoblast differentiation in these cells.
Data (including data from studies in transgenic mice) suggest that Esr1 signaling promotes activation of Pp2a; here, central activation of Pp2a during estrogen replacement therapy is involved in prevention of menopause-induced obesity and glucose intolerance (that is, induced by lack of membrane-initiated Esr1 signaling). (Esr1 = estrogen receptor 1; Pp2a = protein phosphatase 2A)
The data also suggest that H2A.Z (show H2AFZ Antibodies) restricts transcription, which is moderated by ANP32e (show ANP32E Antibodies) at the promoter and gene bodies of expressed genes. Thus, ANP32e (show ANP32E Antibodies), through inhibition of PP2A (show PPP2R2B Antibodies), is required for nucleosomal inclusion of H2A.Z (show H2AFZ Antibodies) and the regulation of gene expression
PP2A (show PPP2R2B Antibodies) is a target of piperine, which induces autophagy in a rotenone-induced Parkinson's disease model
In vitro, SCF (show KITLG Antibodies) induced the phosphorylation of p38 MAPK (show MAPK14 Antibodies) and cofilin (show CFL1 Antibodies), leading to the migration of cardiac stem cells.
We describe a novel mechanism of signal transduction enriched in medium spiny neurons of striatum that likely mediates effects of the neurotransmitter dopamine acting on these cells. We find that the protein ARPP-16, which is highly expressed in striatal medium spiny neurons, acts as a selective inhibitor of certain forms of the serine/threonine protein phosphatase, PP2A, when phosphorylated by the kinase, MAST3.
data show that Fyn (show FYN Antibodies) kinase is activated after TLR4 (show TLR4 Antibodies) triggering and exerts an important negative control on LPS (show TLR4 Antibodies)-dependent TNF (show TNF Antibodies) production in mast cells controlling the inactivation of PP2Ac and activation of PKCalpha (show PKCa Antibodies)/beta necessary for the secretion of TNF (show TNF Antibodies) by VAMP3 (show VAMP3 Antibodies)(+) carriers
endogenous siRNA (PTEN-sh-3p21) cleaved from PTEN-sh within PTEN mRNA 3'UTR modulates PPP2CA and PTEN at the post-transcriptional level in liver cells
PP2A (show PPP2R2B Antibodies) activation both limited and prevented inflammation and tissue injury in two direct injury models of Acute respiratory distress syndrome.
PP2A (show PPP2R2B Antibodies) regulates kinetochore-microtubule attachment during meiosis I in oocyte.
changes in PP2A (show PPP2R2B Antibodies) activity due to methylation and tyrosine phosphorylation occur in sperm; these changes may play an important role in the regulation of sperm function
The findings demonstrate an endothelial VEGF (show VEGFA Antibodies) resistance mechanism conferred by palmitic acid, which comprises ceramide-induced, PP2A (show PPP2R2B Antibodies)-mediated dephosphorylation of critical activation sites on enzymes central to vascular homeostasis and angiogenesis.
PP2A (show PPP2R2B Antibodies) and AIP1 (show PDCD6IP Antibodies) cooperatively induce activation of ASK1 (show MAP3K5 Antibodies)-JNK (show MAPK8 Antibodies) signaling and vascular endothelial cell apoptosis.
Hsp27 (show HSPB1 Antibodies) is dephosphorylated by PP2A (show PPP2R2B Antibodies) in dorsal ruffles, in non-caveolar lipid raft microdomains.
This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit.
, protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform
, protein phosphatase 2A catalytic subunit, alpha isoform
, replication protein C
, serine/threonine protein phosphatase 2A, catalytic subunit, alpha isoform
, serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
, protein phosphatase 2a, catalytic subunit, alpha isoform
, protein phosphatase 2, catalytic subunit, alpha isoform
, protein phosphatase-2A-alpha
, protein phosphatase 2A alpha subunit
, protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform
, type 2A protein phosphatase catalytic subunit
, protein phosphatase 2, catalytic subunit, beta isoform
, protein phosphatase 2, catalytic subunit, alpha isozyme
, serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like