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Human PPP2R1A Protein expressed in Wheat germ - ABIN1316014
Lao, Yusoff, Chandramouli, Philp, Fong, Jackson, Saw, Yu, Guy: Direct binding of PP2A to Sprouty2 and phosphorylation changes are a prerequisite for ERK inhibition downstream of fibroblast growth factor receptor stimulation. in The Journal of biological chemistry 2007
oocyte-specific deletion of Ppp2r1a led to severe female subfertility without affecting follicle survival, growth, and ovulation.
A Pak1-PP2A-ERM signaling axis mediates F-actin rearrangement and degranulation in mast cells.
PP2A (show PPP2R2B Proteins) (Protein Phosphatase 2A(Twins)) counteracts Plk4 (show PLK4 Proteins) autophosphorylation, thus stabilizing Plk4 (show PLK4 Proteins) and promoting centriole duplication
PP2A (show PPP2R2B Proteins)-A alpha transcriptional regulation is mediated by multiple factors including AP-2alpha (show TFAP2A Proteins), CREB (show CREB1 Proteins), ETS-1 (show ETS1 Proteins), and SP-1 (show SP1 Proteins)
Data show that DSB promote PP2A to associate with Ku 70 and Ku 86.
protein phosphatase 2A overexpression in NIH 3T3 cells
T-cell receptor (TCR)-dependent tyrosine phosphorylation may be the mechanism by which the regulatory subunit of PP2A (show PPP2R2B Proteins) prevents the inhibitory function of CTLA-4 (show CTLA4 Proteins), before TCR-CTLA-4 (show CTLA4 Proteins) coligation.
PP-2A regulation of paxillin (show PXN Proteins) phosphorylation may have a role in controlling tumor cell adherence and motility.
PP2A (show PPP2R2B Proteins) may contribute to melanoma cell radioresistance: the truncated isoform of the PP2A (show PPP2R2B Proteins) B56gamma regulatory subunit reduces irradiation-induced Mdm2 (show MDM2 Proteins) phosphorylation
PP2A (show PPP2R2B Proteins) has a fundamental role in cardiac function
PPP2R1A mutations occur in a subset of gastrointestinal stromal tumors and are associated with a high malignant potential that leads to decreased disease-free survival and overall survival
Results demonstrated that the promotive effect of eEF-2K (show EEF2K Proteins) on glycolysis resulted from the kinase-mediated restriction of synthesis of the protein phosphatase 2A-A (PP2A (show PPP2R4 Proteins)-A).
PPP2R1A mutation is associated with endometrial carcinoma progression and abdominopelvic metastasis.
PPP2R1A mutations affect PP2A (show PPP2R4 Proteins) function and oncogenic signaling, illuminating the genetic basis for serous EC development.
PR65A phosphorylation regulates PP2A (show PPP2R4 Proteins) complex signaling.
Our results suggest that IH-induced ROS (show ROS1 Proteins) generation increases PP2A (show PPP2R4 Proteins) activation and subsequently downregulates ERK1/2 activation, which results in inhibition of PC12 cell proliferation through G0/G1 phase arrest and NGF (show NGFB Proteins)-induced neuronal differentiation.
The two functional variants in PPP2R1A and PPP2R5E (show PPP2R5E Proteins) and their combinations are associated with lung cancer risk in the Chinese.
Partial unfolding of PR65/A impacts catalysis by altering the proximity of bound catalytic subunit and substrate.
For PPP2R1A, a heterozygous, somatic mutation (c.771G>T, p.W257C) was identified in 1 out of 37 patients (2.7%) with primary ovarian endometrioid carcinoma.
gene transcription of PPP2R1A regulated by the polymorphism and methylation in the promoter region
This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described.
protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform
, platelet-derived growth factor subunit B
, protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform
, alpha isoform of regulatory subunit A, protein phosphatase 2
, protein phosphatase 2 (formerly 2A), regulatory subunit A , alpha isoform
, protein phosphatase 2, regulatory subunit A, alpha
, serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
, serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like
, PP2A subunit A isoform PR65-alpha
, PP2A subunit A isoform R1-alpha
, protein phosphatase PP2A
, serine/threonine protein phosphatase A subunit type 2A
, protein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoform
, medium tumor antigen-associated 61 KDA protein
, serine/threonine protein phosphatase 2A, 65 kDa regulatory subunit A, alpha isoform
, medium tumor antigen-associated 61 kDa protein
, protein phosphatase 2A 65 kDa regulatory subunit, alpha isoform