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Multiple transcription factors regulate the PP2A-Abeta gene.
PP-2A is less abundant than PP-1 in the mouse eye and appear to be highly regulated by various regulatory subunits; the genes encoding PP-1alpha/beta, PP-2Aalpha/beta, PP-2A-Aalpha/beta, and PP-2A-B alpha/beta/gamma are all differentially expressed.
MicroRNA-587 antagonizes 5-fluorouracil-induced apoptosis and confers drug resistance by regulating PPP2R1B expression in colorectal cancer.
For PPP2R1B, no mutations were detected in our samples.
Data show that the only gene that was expressed, although not at high levels, in all the cells carrying the 11q23.1 amplification was PPP2R1B.
Data show that PR65-dominated fluctuations of PP2A have the effect of opening and closing the enzyme's substrate binding/catalysis interface, as well as altering the positions of certain catalytic residues.
Data show that upon hypoxia, the TGF-beta-induced phosphorylation of Smad3 was inhibited, although Smad2 remained phosphorylated, and Smad3 was dephosphorylated by PP2A.
apoptosis mediated by Fas, TNF-alpha, and TRAIL in U937 cells is suppressed by calyculin A, an inhibitor of type-1 and type-2A protein phosphatases
PPP2R1B has a role in regulating activity of specific downstream target proteins for cell cycle regulation in colorectal cancers
Functional interaction between PR65, a regulatory subunit of the protein phosphatase 2A (PP2A), and CFTR was shown.
These data suggest the possibility that aberrant transcripts of PPP2R1B might be associated with the development of HCC.
PPP2R1B genes may not play a role in the carcinogenesis of cervical cancer. Mutations of PPP2R1B gene are not frequent in cervical cancer.
PPP2R1B, together with NPAT and CUL5, is implicated in the deregulation of the cell-cycle and apoptosis regulators and in the pathogenesis of B-CLL.
These observations identify PP2A Abeta as a tumor suppressor gene that transforms immortalized human cells by regulating the function of RalA.
This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated with some lung and colon cancers. Alternatively spliced transcript variants have been described.
PP2A subunit A isoform PR65-beta
, PP2A subunit A isoform R1-beta
, serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
, PP2A, subunit A, PR65-beta isoform
, PP2A, subunit A, R1-beta isoform
, protein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoform
, protein phosphatase 2, structural/regulatory subunit A, beta
, protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), beta isoform
, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
, protein phosphatase 2A 65 kDa regulatory subunit, beta isoform
, phosphorylase phosphatase