Browse our PPP2R2B Proteins (PPP2R2B)

The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B55 subfamily. Defects in this gene cause autosomal dominant spinocerebellar ataxia 12 (SCA12), a disease caused by degeneration of the cerebellum, sometimes involving the brainstem and spinal cord, and in resulting in poor coordination of speech and body movements. Multiple alternatively spliced variants, which encode different isoforms, have been identified for this gene. The 5' UTR of some of these variants includes a CAG trinucleotide repeat sequence (7-28 copies) that can be expanded to 66-78 copies in cases of SCA12.

• protein phosphatase 2 regulatory subunit Bbeta (PPP2R2B)
• protein phosphatase 2, regulatory subunit B, beta (Ppp2r2b)
• protein phosphatase 2 regulatory subunit B, beta L homeolog (ppp2r2b.L)
• protein phosphatase 2 regulatory subunit B, beta (ppp2r2b)
• protein phosphatase 2, regulatory subunit B, beta b (ppp2r2bb)
• Show all gene names
• protein phosphatase 2 regulatory subunit Bbeta (Ppp2r2b)

• 2900026H06Rik protein
• 6330404L05Rik protein
• B55BETA protein
• E130009M08Rik protein
• PP2A protein
• Show all synonym aliases
• PP2A-PR55B protein
• PP2AB55BETA protein
• PP2ABBETA protein
• PP2APR55B protein
• PP2APR55BETA protein
• PPP2R2B protein
• ppp2r2b-a protein
• ppp2r2c protein
• Pppr2b2 protein
• PR2AB55BETA protein
• PR2ABBETA protein
• PR2APR55BETA protein
• PR52B protein
• PR55-BETA protein
• PR55BETA protein
• SCA12 protein
• zgc:101861 protein

PP2A subunit B isoform B55-beta , PP2A subunit B isoform PR55-beta , PP2A subunit B isoform R2-beta , PP2A, subunit B, B-beta isoform , protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform , protein phosphatase 2 (formerly 2A), regulatory subunit B, beta isoform , serine/threonine protein phosphatase 2A, 55 kDa regulatory subunit B, beta isoform , serine/threonine protein phosphatase 2A, neuronal isoform , serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform , BRbeta B-regulatory subunit of protein phosphatase 2A , PP2A subunit B isoform BRB , PP2A subunit B isoform beta , PP2A, subunit B, B55-beta isoform , PP2A, subunit B, BRB isoform , PP2A, subunit B, PR55-beta isoform , PP2A, subunit B, R2-beta isoform , phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform , protein phosphatase 2A 55 kDa regulatory subunit, beta isoform , beta isoform of regulatory subunit B55, protein phosphatase 2 , protein phosphatase-2A subunit-beta , protein phosphatase 2, regulatory subunit B, beta , serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform-like