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Dephosphorylation and total levels of beta-catenin (show CTNNB1 Proteins) were dependent on PR55beta in an adenoid cystic carcinoma tumor cell line.
New pathogenic threshold of PPP2R2B CAG-43 to be pathogenic for SCA12 diagnosis.
CAG triplet repeat expansion has been found in untranslated region of SCA12 gene in Indian spinocerebellar ataxia 12 patients.
Thus, Fcp1 (show CTDP1 Proteins) coordinates Cdk1 (show CDK1 Proteins) and Gwl (show MASTL Proteins) inactivation to derepress PP2A (show PPP2R4 Proteins)-B55 (show MINK1 Proteins), generating a dephosphorylation switch that drives mitosis progression.
investigated CAG copies within PPP2R2B in 29 patients with spinocerebellar ataxia who are excluded from the most common subtypes; 3 patients carried 53, 46 and 54 CAG repeats respectively, while the other 26 cases harbored CAG repeats less than 30
IER5 (show IER5 Proteins) functions as a positive feedback regulator of HSF1 (show HSF1 Proteins) and that this process involves PP2A (show PPP2R4 Proteins)/B55 (show MINK1 Proteins) and HSF1 (show HSF1 Proteins) dephosphorylation.
Bcl-2 (show BCL2 Proteins) phosphorylation at Ser70 by selective tyrosine nitration of PP2A (show PPP2R4 Proteins)-B56delta stabilizes its antiapoptotic activity
Inactivation of protein-phosphatase 2A causing hyperphosphorylation of paraprotein targets in monoclonal gammopathy of undetermined significance, multiple myeloma and Waldenstrom's macroglobulinemia is due to an exchange of its regulatory subunits
Identification of the adenovirus E4orf4 protein binding site on the B55alpha (show PPP2R2A Proteins) and Cdc55 regulatory subunits of PP2A (show PPP2R4 Proteins): Implications for PP2A (show PPP2R4 Proteins)
We demonstrate that PP2A/B55 is required for Gwl dephosphorylation at the essential Cdk site Thr194. Ensa/ARPP19 dephosphorylation is mediated by the RNA
PP-2A is less abundant than PP-1 in the mouse eye and appear to be highly regulated by various regulatory subunits; the genes encoding PP-1alpha/beta, PP-2Aalpha/beta, PP-2A-Aalpha/beta, and PP-2A-B alpha/beta/gamma are all differentially expressed.
Together, these results indicate that capsaicin inhibits the patterning of the dorso-ventral and anterior-posterior body axes of embryo by repressing PP2A and thereby down-regulating the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling.
equilibrium between CDK1 (show CDK1 Proteins) and PP2A specifies the timing of M-phase entry and exit and regulates the dynamics of cyclin B degradation upon M-phase exit in Xenopus laevis first embryonic mitosis.
inhibition of PP2A-B55delta results from Ensa (show ENSA Proteins), that is phosphorylated in mitosis by the protein kinase (show CSNK1D Proteins) Greatwall (show MASTL Proteins); this converts Ensa (show ENSA Proteins) into specific inhibitor of PP2A-B55delta; this pathway represents a previously unknown element in mitosis control
study describes how Gwl (show MASTL Proteins) activation results in PP2A inhibition; identified Arpp19 (show ARPP19 Proteins) and alpha-Endosulfine (show ENSA Proteins) that, when phosphorylated by Gwl (show MASTL Proteins), associate with and inhibit PP2A promoting mitotic entry
TRPV1 (show TRPV1 Proteins) activation in endothelial cells may elicit a Ca(2 (show CA2 Proteins)+) -dependent effect on PP2B-PKC signalling, which leads to dephosphorylation of eNOS (show NOS3 Proteins)
The protein phosphatase PP2A/Balpha binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn (show FYN Proteins).
The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B55 subfamily. Defects in this gene cause autosomal dominant spinocerebellar ataxia 12 (SCA12), a disease caused by degeneration of the cerebellum, sometimes involving the brainstem and spinal cord, and in resulting in poor coordination of speech and body movements. Multiple alternatively spliced variants, which encode different isoforms, have been identified for this gene. The 5' UTR of some of these variants includes a CAG trinucleotide repeat sequence (7-28 copies) that can be expanded to 66-78 copies in cases of SCA12.
PP2A subunit B isoform B55-beta
, PP2A subunit B isoform PR55-beta
, PP2A subunit B isoform R2-beta
, PP2A, subunit B, B-beta isoform
, protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
, protein phosphatase 2 (formerly 2A), regulatory subunit B, beta isoform
, serine/threonine protein phosphatase 2A, 55 kDa regulatory subunit B, beta isoform
, serine/threonine protein phosphatase 2A, neuronal isoform
, serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
, BRbeta B-regulatory subunit of protein phosphatase 2A
, PP2A subunit B isoform BRB
, PP2A subunit B isoform beta
, PP2A, subunit B, B55-beta isoform
, PP2A, subunit B, BRB isoform
, PP2A, subunit B, PR55-beta isoform
, PP2A, subunit B, R2-beta isoform
, phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
, protein phosphatase 2A 55 kDa regulatory subunit, beta isoform
, beta isoform of regulatory subunit B55, protein phosphatase 2
, protein phosphatase-2A subunit-beta
, protein phosphatase 2, regulatory subunit B, beta
, serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform-like